TY - JOUR TI - [Transmission of death certificates to CepiDc-Inserm related to suspicious deaths, in France, since 2000] AU - Richaud-Eyraud, E. AU - Rondet, C. AU - Rey, G. T2 - Revue D'epidemiologie Et De Sante Publique AB - BACKGROUND: The purpose of this study is to assess variability in death certificates' transmission related to suspicious deaths. METHODS: The medical part of death certificates of suspicious deaths (violent or sudden deaths, unknown or ill-defined causes of death) were examined. We studied the frequency of suspicious deaths, in France, for deaths aged under 65, from 2000 to 2013, searching for temporal (2000-2013) and spatial correlations between unknown causes of death and other suspicious causes, and report of an autopsy. These results were compared with external data. RESULTS: Standardized proportion of deaths by unknown cause more than doubled during the study period (from 3.4 to 7.5%). The spatial correlation was strongly negative between standardized proportions of unknown causes of death and violent deaths (ICC=-0.80). Report of autopsy varied with cause of suspicious death and estimated zone of the forensic institute. The distribution was consistently distributed with external data, except for homicides. CONCLUSION: Information transmission to CépiDc-Inserm needs to be improved in case of suspicious death, in particularly from forensic institutes. This study emphasizes the urgent need for a complementary form to the death certificate. DA - 2018/03// PY - 2018 DO - 10.1016/j.respe.2017.11.006 DP - PubMed VL - 66 IS - 2 SP - 125 EP - 133 J2 - Rev Epidemiol Sante Publique LA - fr SN - 0398-7620 KW - Autopsie KW - Autopsy KW - Cause de décès KW - Certificats de décès KW - Médecine légale KW - Suicide ER - TY - JOUR TI - A Joint modelling of socio-professional trajectories and cause-specific mortality AU - Karimi, M. AU - Rey, G. AU - Latouche, A. T2 - Computational Statistics & Data Analysis AB - The association between life-course socio-professional trajectories and mortality has already been discussed in the literature. However, these socio-professional trajectories may be subject to informative censoring due to death. This loss to follow-up which is related to an individual’s survival, should not be ignored and thus, it is of interest to model jointly these professional trajectories and their survival. The main focus has been made on continuous, binary or ordinal variables while much less attention has been paid to nominal categorical data. Therefore, an extension to the joint modelling of longitudinal nominal data and survival under a likelihood-based approach is proposed. A generalized linear mixed model is considered for modelling the longitudinal nominal data, in addition to two cause-specific proportional hazards model for the survival competing risks data. The association between longitudinal and survival outcomes is captured by assuming a multivariate Gaussian distribution for the joint distribution of the random effects of two sub-models. The proposed joint model provides a robust framework for estimating longitudinal membership probabilities, accounting for informative censoring caused by individual’s death. Simulations are carried out to assess the performance of this joint model comparing with the results of the separate longitudinal and competing risks analysis. A disadvantage of joint models is that they are computationally intensive. To overcome this problem, an approach mimicking a meta-analysis strategy of individual participant data is suggested. The relevance of this approach is then illustrated on a large sample of the French salaried population, which contains all employment records between 1976 and 2002. DA - 2018/03/01/ PY - 2018 DO - 10.1016/j.csda.2017.10.002 DP - ScienceDirect VL - 119 SP - 39 EP - 54 J2 - Computational Statistics & Data Analysis SN - 0167-9473 UR - http://www.sciencedirect.com/science/article/pii/S0167947317302207 Y2 - 2018/05/14/13:19:51 KW - Cause-specific hazards KW - Generalized linear mixed model KW - Joint model KW - Large-scale data KW - Membership probability ER - TY - JOUR TI - Why underserved patients do not consult their general practitioner for depression: results of a qualitative and a quantitative survey at a free outpatient clinic in Paris, France AU - Rondet, Claire AU - Parizot, Isabelle AU - Cadwallader, Jean Sebastien AU - Lebas, Jacques AU - Chauvin, Pierre T2 - BMC Family Practice DA - 2015/12// PY - 2015 DO - 10.1186/s12875-015-0273-2 DP - CrossRef VL - 16 IS - 1 LA - eng SN - 1471-2296 ST - Why underserved patients do not consult their general practitioner for depression UR - http://bmcfampract.biomedcentral.com/articles/10.1186/s12875-015-0273-2 Y2 - 2018/01/03/13:25:33 ER - TY - JOUR TI - Quantifying cause-related mortality by weighting multiple causes of death AU - Piffaretti, Clara AU - Moreno-Betancur, Margarita AU - Lamarche-Vadel, Agathe AU - Rey, Grégoire T2 - Bulletin of the World Health Organization AB - OBJECTIVE: To investigate a new approach to calculating cause-related standardized mortality rates that involves assigning weights to each cause of death reported on death certificates. METHODS: We derived cause-related standardized mortality rates from death certificate data for France in 2010 using: (i) the classic method, which considered only the underlying cause of death; and (ii) three novel multiple-cause-of-death weighting methods, which assigned weights to multiple causes of death mentioned on death certificates: the first two multiple-cause-of-death methods assigned non-zero weights to all causes mentioned and the third assigned non-zero weights to only the underlying cause and other contributing causes that were not part of the main morbid process. As the sum of the weights for each death certificate was 1, each death had an equal influence on mortality estimates and the total number of deaths was unchanged. Mortality rates derived using the different methods were compared. FINDINGS: On average, 3.4 causes per death were listed on each certificate. The standardized mortality rate calculated using the third multiple-cause-of-death weighting method was more than 20% higher than that calculated using the classic method for five disease categories: skin diseases, mental disorders, endocrine and nutritional diseases, blood diseases and genitourinary diseases. Moreover, this method highlighted the mortality burden associated with certain diseases in specific age groups. CONCLUSION: A multiple-cause-of-death weighting approach to calculating cause-related standardized mortality rates from death certificate data identified conditions that contributed more to mortality than indicated by the classic method. This new approach holds promise for identifying underrecognized contributors to mortality. DA - 2016/12/01/ PY - 2016 DO - 10.2471/BLT.16.172189 DP - PubMed VL - 94 IS - 12 SP - 870 EP - 879 J2 - Bull. World Health Organ. LA - eng SN - 1564-0604 ER - TY - JOUR TI - Trends in geographic mortality inequalities and their association with population changes in France, 1975-2006 AU - Ghosn, Walid AU - Kassié, Daouda AU - Jougla, Eric AU - Salem, Gérard AU - Rey, Grégoire AU - Rican, Stéphane T2 - European journal of public health AB - BACKGROUND: Although some studies have reported that population change is associated with spatial mortality inequalities, few of them have tried to take a dynamic approach to the association. The aim of this study was to explore and interpret the ecological association between the change in cause-specific mortality inequalities and population change over a 30-year period in areas exhibiting different deprivation and urbanization levels in France. METHODS: The French communes were classified by category of demographic change during the period 1962-2006. The changes in standardized mortality ratios were analysed by category over 5 inter-censal periods, taking into account degree of urbanization and deprivation quintile. The magnitude and significance of the associations for various causes of death were estimated using a Generalised Estimating Equation Poisson model. RESULTS: Overall, the change in relative mortality was negatively associated with population growth. For a compound annual population growth rate of 1% in 1990-99, the standardized mortality ratios decreased, on average, by 2.1% (95% confidence interval: -1.45 to -2.72). The association was stronger in urban areas, and reversed in the least deprived areas. The association was stronger and more significant for men, subjects aged less than 65 years and alcohol-related and violent deaths. CONCLUSION: This study highlights the significance of dynamic approaches. Population growth was associated with a decrease in relative mortality level; the direction and strength of the association varied depending on the socio-territorial characteristics. As is the case for English-speaking countries, in France, population growth may be considered a component of current social dynamics that are not measured by usual indicators. DA - 2013/10// PY - 2013 DO - 10.1093/eurpub/cks078 DP - NCBI PubMed VL - 23 IS - 5 SP - 834 EP - 840 J2 - Eur J Public Health LA - eng SN - 1464-360X ER - TY - JOUR TI - The excess mortality related to cardiovascular diseases and cancer among adults pharmacologically treated for diabetes--the 2001-2006 ENTRED cohort AU - Romon, I. AU - Rey, G. AU - Mandereau-Bruno, L. AU - Weill, A. AU - Jougla, E. AU - Eschwège, E. AU - Simon, D. AU - Druet, C. AU - Fagot-Campagna, A. T2 - Diabetic Medicine: A Journal of the British Diabetic Association AB - AIMS: To compare the 5-year mortality (overall and cause-specific) of a cohort of adults pharmacologically treated for diabetes with that of the rest of the French adult population. METHODS: In 2001, 10 000 adults treated for diabetes were randomly selected from the major French National Health Insurance System database. Vital status and causes of death were successfully extracted from the national registry for 9101 persons. We computed standardized mortality ratios. RESULTS: Over 5 years, 1388 adults pharmacologically treated for diabetes died (15% of the cohort, 32.4/1000 person-years). An excess mortality, which decreased with age, was found for both genders [standardized mortality ratio 1.45 (1.37-1.52)]. Excess mortality was related to: hypertensive disease [2.90 (2.50-3.33)], ischaemic heart disease [2.19 (1.93-2.48)], cerebrovascular disease [1.76 (1.52-2.03)], renal failure [2.14 (1.77-2.56)], hepatic failure [2.17 (1.52-3.00)] in both genders and septicaemia among men [1.56 (1.15-2.09)]. An association was also found with cancer-related mortality: liver cancer in men [3.00 (2.10-4.15)]; pancreatic cancer in women [3.22 (1.94-5.03)]; colon/rectum cancer in both genders [1.66 (1.28-2.12)]. Excess mortality was not observed for breast, lung or stomach cancers. CONCLUSIONS: Adults pharmacologically treated for diabetes had a 45% increased risk of mortality at 5 years, mostly related to cardiovascular complications, emphasizing the need for further prevention. The increased risk of mortality from cancer raises questions about the relationship between cancer and diabetes and prompts the need for improved cancer screening in people with diabetes. DA - 2014/08// PY - 2014 DO - 10.1111/dme.12435 DP - PubMed VL - 31 IS - 8 SP - 946 EP - 953 J2 - Diabet. Med. LA - eng SN - 1464-5491 KW - Aged KW - Aged, 80 and over KW - Cardiovascular Diseases KW - Cohort Studies KW - Colorectal Neoplasms KW - Diabetes Mellitus, Type 1 KW - Diabetes Mellitus, Type 2 KW - Female KW - Follow-Up Studies KW - France KW - Humans KW - Hypoglycemic Agents KW - Liver Neoplasms KW - Male KW - Middle Aged KW - Mortality KW - National Health Programs KW - Pancreatic Neoplasms KW - Registries KW - Risk Factors KW - Sex Characteristics KW - Survival Analysis ER - TY - JOUR TI - Spatial interactions between urban areas and cause-specific mortality differentials in France AU - Ghosn, Walid AU - Kassie, Daouda AU - Jougla, Eric AU - Rican, Stéphane AU - Rey, Grégoire T2 - Health & place AB - Spatial interactions constitute a challenging but promising approach for investigation of spatial mortality inequalities. Among spatial interactions measures, between-spatial unit migration differentials are a marker of socioeconomic imbalance, but also reflect discrepancies due to other factors. Specifically, this paper asks whether population exchange intensities measure differentials or similarities that are not captured by usual socioeconomic indicators. Urban areas were grouped pairwise by the intensity of connection estimated from a gravity model. The mortality differences for several causes of death were observed to be significantly smaller for strongly connected pairs than for weakly connected pairs even after adjustment on deprivation. DA - 2013/11// PY - 2013 DO - 10.1016/j.healthplace.2013.10.003 DP - NCBI PubMed VL - 24 SP - 234 EP - 241 J2 - Health Place LA - eng SN - 1873-2054 KW - Gravity model KW - Mortality KW - Spatial inequalities KW - Spatial interactions KW - migration ER - TY - JOUR TI - Socioprofessional trajectories and mortality in France, 1976-2002: a longitudinal follow-up of administrative data AU - Karimi, Maryam AU - Geoffroy-Perez, Béatrice AU - Fouquet, Aurélie AU - Latouche, Aurélien AU - Rey, Grégoire T2 - Journal of Epidemiology and Community Health AB - BACKGROUND: Occupying a low socioeconomic position is associated with increased mortality risk. To disentangle this association, previous studies considered various dimensions of socioeconomic trajectories across the life course. However, they used a limited number of stages. We simultaneously examined various dimensions of the whole professional trajectory and its association with mortality. METHODS: We used a large sample (337,706 men and 275,378 women) of the data obtained by linking individuals' annual occupation (collected in 1976-2002 from a representative panel of the French salaried population in the semipublic and private sectors) with causes of death obtained from registries. All-cause and cause-specific HRs were estimated using Cox's regression models adjusted for the occupational class at the beginning of the follow-up, the current occupational class, the transition rates between occupational categories and the duration of time spent in occupational categories. RESULTS: An increase in the time spent in the clerk class increased men and women's cardiovascular mortality risk compared with that in the upper class (HRs=1.59 (1.14 to 2.20) and 2.65 (1.14 to 6.13) for 10 years increase, respectively, for men and women). Men with a high rate of transitions had about a 1.2-fold increased risk of all-cause and external-cause mortality compared with those without transitions during their professional life. This association was also observed for women's all-cause mortality. CONCLUSIONS: Strong associations between professional trajectories and mortality from different causes of death were found. Long exposure to lower socioeconomic conditions was associated with increased mortality risk from various causes of death. The results also suggest gradual associations between transition rates and mortality. DA - 2015/04// PY - 2015 DO - 10.1136/jech-2014-204615 DP - PubMed VL - 69 IS - 4 SP - 339 EP - 346 J2 - J Epidemiol Community Health LA - eng SN - 1470-2738 ST - Socioprofessional trajectories and mortality in France, 1976-2002 KW - Adult KW - Female KW - Follow-Up Studies KW - France KW - Humans KW - Life course epidemiology KW - Male KW - Middle Aged KW - Mortality KW - Mortality, Premature KW - Multivariate Analysis KW - Occupations KW - Proportional Hazards Models KW - SOCIAL INEQUALITIES KW - Social Class KW - Social Mobility ER - TY - JOUR TI - Sizable variations in circulatory disease mortality by region and country of birth in six European countries AU - Rafnsson, Snorri B AU - Bhopal, Raj S AU - Agyemang, Charles AU - Fagot-Campagna, Anne AU - Harding, Seeromanie AU - Hammar, Niklas AU - Hedlund, Ebba AU - Juel, Knud AU - Primatesta, Paola AU - Rosato, Michael AU - Rey, Gregoire AU - Wild, Sarah H AU - Mackenbach, Johan P AU - Stirbu, Irene AU - Kunst, Anton E T2 - European journal of public health AB - BACKGROUND: Circulatory disease mortality inequalities by country of birth (COB) have been demonstrated for some EU countries but pan-European analyses are lacking. We examine inequalities in circulatory mortality by geographical region/COB for six EU countries. METHODS: We obtained national death and population data from Denmark, England and Wales, France, the Netherlands, Scotland and Sweden. Mortality rate ratios (MRRs) were constructed to examine differences in circulatory, ischaemic heart disease (IHD) and cerebrovascular disease mortality by geographical region/COB in 35-74 years old men and women. RESULTS: South Asians in Denmark, England and Wales and France experienced excess circulatory disease mortality (MRRs 1.37-1.91). Similar results were seen for Eastern Europeans in these countries as well as in Sweden (MRRs 1.05-1.51), for those of Middle Eastern origin in Denmark (MRR = 1.49) and France (MRR = 1.15), and for East and West sub-Saharan Africans in England and Wales (MRRs 1.28 and 1.39) and France (MRRs 1.24 and 1.22). Low ratios were observed for East Asians in France, Scotland and Sweden (MRRs 0.64-0.50). Sex-specific analyses showed results of similar direction but different effect sizes. The pattern for IHD mortality was similar to that for circulatory disease mortality. Two- to three-fold excess cerebrovascular disease mortality was found for several foreign-born groups compared with the local-born populations in some countries. CONCLUSIONS: Circulatory disease mortality varies by geographical region/COB within six EU countries. Excess mortality was observed for some migrant populations, less for others. Reliable pan-European data are needed for monitoring and understanding mortality inequalities in Europe's multiethnic populations. DA - 2013/08// PY - 2013 DO - 10.1093/eurpub/ckt023 DP - NCBI PubMed VL - 23 IS - 4 SP - 594 EP - 605 J2 - Eur J Public Health LA - eng SN - 1464-360X ER - TY - JOUR TI - Sarcoidosis-related mortality in France: a multiple-cause-of-death analysis AU - Jamilloux, Yvan AU - Maucort-Boulch, Delphine AU - Kerever, Sébastien AU - Gerfaud-Valentin, Mathieu AU - Broussolle, Christiane AU - Eb, Mireille AU - Valeyre, Dominique AU - Seve, Pascal T2 - The European Respiratory Journal AB - We evaluated mortality rates and underlying causes of death among French decedents with sarcoidosis from 2002 to 2011.We used data from the French Epidemiological Centre for the Medical Causes of Death to 1) calculate sarcoidosis-related mortality rates, 2) examine differences by age and gender, 3) determine underlying and nonunderlying causes of death, 4) compare with the general population (observed/expected ratios), and 5) analyse regional differences.1662 death certificates mentioning sarcoidosis were recorded. The age-standardised mortality rate was 3.6 per million population and significantly increased over the study period. The mean age at death was 70.4 years (versus 76.2 years for the general population). The most common underlying cause of death was sarcoidosis. Sarcoidosis decedents were more likely to be males when aged 1 for infectious disease, tuberculosis and chronic respiratory disease, and TY - JOUR TI - Relative index of inequality and slope index of inequality: a structured regression framework for estimation AU - Moreno-Betancur, Margarita AU - Latouche, Aurélien AU - Menvielle, Gwenn AU - Kunst, Anton E. AU - Rey, Grégoire T2 - Epidemiology (Cambridge, Mass.) AB - BACKGROUND: The relative index of inequality and the slope index of inequality are the two major indices used in epidemiologic studies for the measurement of socioeconomic inequalities in health. Yet the current definitions of these indices are not adapted to their main purpose, which is to provide summary measures of the linear association between socioeconomic status and health in a way that enables valid between-population comparisons. The lack of appropriate definitions has dissuaded the application of suitable regression methods for estimating the slope index of inequality. METHODS: We suggest formally defining the relative and slope indices of inequality as so-called least false parameters, or more precisely, as the parameters that provide the best approximation of the relation between socioeconomic status and the health outcome by log-linear and linear models, respectively. From this standpoint, we establish a structured regression framework for inference on these indices. Guidelines for implementation of the methods, including R and SAS codes, are provided. RESULTS: The new definitions yield appropriate summary measures of the linear association across the entire socioeconomic scale, suitable for comparative studies in epidemiology. Our regression-based approach for estimation of the slope index of inequality contributes to an advancement of the current methodology, which mainly consists of a heuristic formula relying on restrictive assumptions. A study of the educational inequalities in all-cause and cause-specific mortality in France is used for illustration. CONCLUSION: The proposed definitions and methods should guide the use and estimation of these indices in future studies. DA - 2015/07// PY - 2015 DO - 10.1097/EDE.0000000000000311 DP - PubMed VL - 26 IS - 4 SP - 518 EP - 527 J2 - Epidemiology LA - eng SN - 1531-5487 ST - Relative index of inequality and slope index of inequality KW - Educational Status KW - Female KW - France KW - Health Status Disparities KW - Humans KW - Linear Models KW - Male KW - Mortality KW - Proportional Hazards Models KW - Regression Analysis KW - Social Class KW - Socioeconomic Factors KW - Statistics as Topic ER - TY - JOUR TI - Quality comparison of electronic versus paper death certificates in France, 2010 AU - Lefeuvre, Delphine AU - Pavillon, Gérard AU - Aouba, Albertine AU - Lamarche-Vadel, Agathe AU - Fouillet, Anne AU - Jougla, Eric AU - Rey, Grégoire T2 - Population health metrics AB - BACKGROUND: Electronic death certification was established in France in 2007. A methodology based on intrinsic characteristics of death certificates was designed to compare the quality of electronic versus paper death certificates. METHODS: All death certificates from the 2010 French mortality database were included. Three specific quality indicators were considered: (i) amount of information, measured by the number of causes of death coded on the death certificate; (ii) intrinsic consistency, explored by application of the International Classification of Disease (ICD) General Principle, using an international automatic coding system (Iris); (iii) imprecision, measured by proportion of death certificates where the selected underlying cause of death was imprecise. Multivariate models were considered: a truncated Poisson model for indicator (i) and binomial models for indicators (ii) and (iii). Adjustment variables were age, gender, and cause, place, and region of death. RESULTS: 533,977death certificates were analyzed. After adjustment, electronic death certificates contained 19% [17%-20%] more codes than paper death certificates for people deceased under 65 years, and 12% [11%-13%] more codes for people deceased over 65 years. Regarding deceased under and over 65 respectively, the ICD General Principle could be applied 2% [0%-4%] and 6% [5%-7%] more to electronic than to paper death certificates. The proportion of imprecise death certificates was 51% [46%-56%] lower for electronic than for paper death certificates. CONCLUSION: The method proposed to evaluate the quality of death certificates is easily reproducible in countries using an automatic coding system. According to our criteria, electronic death certificates are better completed than paper death certificates. The transition to electronic death certificates is positive in many aspects and should be promoted. DA - 2014/// PY - 2014 DO - 10.1186/1478-7954-12-3 DP - NCBI PubMed VL - 12 IS - 1 SP - 3 J2 - Popul Health Metr LA - eng SN - 1478-7954 ER - TY - JOUR TI - Pitfalls of national routine death statistics for maternal mortality study AU - Saucedo, Monica AU - Bouvier-Colle, Marie-Hélène AU - Chantry, Anne A. AU - Lamarche-Vadel, Agathe AU - Rey, Grégoire AU - Deneux-Tharaux, Catherine T2 - Paediatric and Perinatal Epidemiology AB - BACKGROUND: The lessons learned from the study of maternal deaths depend on the accuracy of data. Our objective was to assess time trends in the underestimation of maternal mortality (MM) in the national routine death statistics in France and to evaluate their current accuracy for the selection and causes of maternal deaths. METHODS: National data obtained by enhanced methods in 1989, 1999, and 2007-09 were used as the gold standard to assess time trends in the underestimation of MM ratios (MMRs) in death statistics. Enhanced data and death statistics for 2007-09 were further compared by characterising false negatives (FNs) and false positives (FPs). The distribution of cause-specific MMRs, as assessed by each system, was described. RESULTS: Underestimation of MM in death statistics decreased from 55.6% in 1989 to 11.4% in 2007-09 (P TY - JOUR TI - Mortality of French participants in the Tour de France (1947-2012) AU - Marijon, Eloi AU - Tafflet, Muriel AU - Antero-Jacquemin, Juliana AU - El Helou, Nour AU - Berthelot, Geoffroy AU - Celermajer, David S AU - Bougouin, Wulfran AU - Combes, Nicolas AU - Hermine, Olivier AU - Empana, Jean-Philippe AU - Rey, Grégoire AU - Toussaint, Jean-François AU - Jouven, Xavier T2 - European heart journal AB - AIMS: In the context of recent concerns regarding performance enhancing techniques and potential negative health effects of high-level physical activity, data on the long-term outcomes and causes of death in elite endurance cyclists are of particular interest. METHODS AND RESULTS: Characteristics and vital status of all French participants in the Tour de France were collected for the 1947-2012 period. Causes of death were obtained from 1968. Overall and disease-specific mortalities were compared with the French male population using overall and specific standardized mortality ratios (SMRs) with their 95% confidence intervals (CIs). Among the 786 French cyclists who participated at least once between 1947 and 2012, 208 (26%) died by 1 September 2012. Neoplasms and cardiovascular diseases accounted for 61% of deaths. We observed a 41% lower mortality in French cyclists (SMR: 0.59, 95% CI: 0.51-0.68, P < 0.0001), which did not change over time (P = 0.70). It was observed for main mortality causes: for neoplasms (SMR: 0.56; 95% CI: 0.42-0.72, P < 0.0001) and for cardiovascular death (SMR: 0.67; 95% CI: 0.50-0.88, P = 0.004), except mortality related to external causes (SMR: 1.06, 95% CI: 0.71-1.53, P = 0.80). CONCLUSION: We observed a substantially and significantly lower mortality in participants in the Tour de France, compared with the general male population. However, our results do not allow us to assess in detail the balance between positive effects of high-level sports activity and selection of healthy elite athletes, vs. any potential deleterious effects of excessive physical exercise or alleged doping. DA - 2013/10// PY - 2013 DO - 10.1093/eurheartj/eht347 DP - NCBI PubMed VL - 34 IS - 40 SP - 3145 EP - 3150 J2 - Eur. Heart J. LA - eng SN - 1522-9645 ER - TY - JOUR TI - Mortality in female and male French Olympians: a 1948-2013 cohort study AU - Antero-Jacquemin, Juliana AU - Rey, Grégoire AU - Marc, Andy AU - Dor, Frédéric AU - Haïda, Amal AU - Marck, Adrien AU - Berthelot, Geoffroy AU - Calmat, Alain AU - Latouche, Aurélien AU - Toussaint, Jean-François T2 - The American Journal of Sports Medicine AB - BACKGROUND: Whereas intense physical activity has been associated with deleterious effects on elite athletes' health, in particular due to cardiovascular anomalies, long-term follow-ups have suggested lower mortality rates among elite athletes. Causes of death for French Olympic athletes and female elite athletes have not been studied. HYPOTHESIS/PURPOSE: We aimed to measure overall and disease-specific mortality of French female and male Olympians compared with the French general population. We hypothesize that Olympians, both women and men, have lower mortality rates. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: French elite athletes (601 women and 1802 men) participating in summer or winter Olympic Games from 1948 to 2010 had their vital status verified by national sources and were followed until 2013. Causes of death were obtained via the National Death registry from 1968 to 2012. Overall and disease-specific mortalities of Olympians were compared with those of the French general population through standardized mortality ratios (SMRs) and 95% CIs. Olympians' observed and expected survivals were illustrated by Kaplan-Meier curves. RESULTS: At the endpoint of the study, 13 women and 222 men had died. Overall mortality in Olympians compared with that of their compatriots was 51% lower (SMR, 0.49; 95% CI, 0.26-0.85) among women and 49% lower (SMR, 0.51; 95% CI, 0.45-0.59) among men. Olympic athletes' survival is significantly superior to that of the French general population (women, P = .03; men, P < .001). According to the total deaths occurring from 1968 to 2012 (12 among women, 202 among men), female Olympians died from neoplasm (50.0%), external causes (33.3%), and cardiovascular diseases (16.6%). The main causes of death among men were related to neoplasms (36.1%), cardiovascular diseases (24.3%), and external causes (14.4%). Regarding the main causes of mortality among male Olympic athletes, the SMRs were as follows: 0.55 for neoplasms (95% CI, 0.43-0.69), 0.55 for cardiovascular diseases (95% CI, 0.41-0.73), and 0.66 for external causes (95% CI, 0.44-0.94). CONCLUSION: French Olympians live longer than their compatriots: A lower overall mortality of similar magnitude is observed among male and female athletes compared with the general population. The main causes of death in French Olympians are neoplasms, cardiovascular diseases, and external causes. DA - 2015/06// PY - 2015 DO - 10.1177/0363546515574691 DP - PubMed VL - 43 IS - 6 SP - 1505 EP - 1512 J2 - Am J Sports Med LA - eng SN - 1552-3365 ST - Mortality in female and male French Olympians KW - Adult KW - Age Distribution KW - Aged KW - Aged, 80 and over KW - Athletes KW - Cardiovascular Diseases KW - Female KW - France KW - Humans KW - Kaplan-Meier Estimate KW - Longevity KW - Male KW - Middle Aged KW - Neoplasms KW - Registries KW - Retrospective Studies KW - Sports KW - disease-specific mortality KW - elite athletes KW - overall mortality ER - TY - JOUR TI - Mortality from circulatory diseases by specific country of birth across six European countries: test of concept AU - Bhopal, Raj S AU - Rafnsson, Snorri B AU - Agyemang, Charles AU - Fagot-Campagna, Anne AU - Giampaoli, Simona AU - Hammar, Niklas AU - Harding, Seeromanie AU - Hedlund, Ebba AU - Juel, Knud AU - Mackenbach, Johan P AU - Primatesta, Paola AU - Rey, Gregoire AU - Rosato, Michael AU - Wild, Sarah AU - Kunst, Anton E T2 - European journal of public health AB - BACKGROUND: Important differences in cardiovascular disease (CVD) mortality by country of birth have been shown within European countries. We now focus on CVD mortality by specific country of birth across European countries. METHODS: For Denmark, England and Wales, France, The Netherlands, Scotland and Sweden mortality information on circulatory disease, and the subcategories of ischaemic heart disease, and cerebrovascular disease, was analysed by country of birth. Information on population was obtained from census data or population registers. Directly age-standardized rates per 100 000 were estimated by sex for each country of birth group using the WHO World Standard population 2000-25 structure. For differences in the results, at least one of the two 95% confidence intervals did not overlap. RESULTS: Circulatory mortality was similar across countries for men born in India (355.7 in England and Wales, 372.8 in Scotland and 244.5 in Sweden). For other country of birth groups-China, Pakistan, Poland, Turkey and Yugoslavia-there were substantial between-country differences. For example, men born in Poland had a rate of 630.0 in Denmark and 499.3 in England and Wales and 153.5 in France; and men born in Turkey had a rate of 439.4 in Denmark and 231.4 in The Netherlands. A similar pattern was seen in women, e.g. Poland born women had a rate of 264.9 in Denmark, 126.4 in England and Wales and 54.4 in France. The patterns were similar for ischaemic heart disease mortality and cerebrovascular disease mortality. CONCLUSION: Cross-country comparisons are feasible and the resulting findings are interesting. They merit public health consideration. DA - 2012/06// PY - 2012 DO - 10.1093/eurpub/ckr062 DP - NCBI PubMed VL - 22 IS - 3 SP - 353 EP - 359 J2 - Eur J Public Health LA - eng SN - 1464-360X ST - Mortality from circulatory diseases by specific country of birth across six European countries KW - Asia KW - Cardiovascular Diseases KW - Cerebrovascular Disorders KW - Cross-Cultural Comparison KW - Europe KW - Female KW - Health Status Disparities KW - Health Surveys KW - Humans KW - Male KW - Sex Factors KW - Socioeconomic Factors ER - TY - JOUR TI - Mortality differences between the foreign-born and locally-born population in France (2004-2007) AU - Boulogne, Roxane AU - Jougla, Eric AU - Breem, Yves AU - Kunst, Anton E AU - Rey, Grégoire T2 - Social science & medicine (1982) AB - In contrast to the situation in many European countries, the mortality of immigrants in France has been little studied. The main reasons for the lack of studies are based on ethical and ideological considerations. The objective of this study is to explore mortality by country of birth in Metropolitan (i.e. 'mainland') France. Complete mortality data were used to study the relative risks of mortality of the foreign- and locally-born populations by gender, age and cause of death for the period 2004-2007 in Metropolitan France. Analyses were conducted by countries of birth grouped into geographic areas and by the Human Development Index (HDI). The differentials in mortality between foreign-born and locally-born populations were not homogeneous. The figures varied by age (higher foreign-born mortality for the young; lower mortality for migrants aged 15-64 years), gender (female migrants more frequently had higher relative mortality than men migrants), country of birth (Eastern European-born migrants had higher mortality, while those born in Morocco, Central Asia, 'other Asian countries' and America had lower mortality) and cause of death (migrant mortality was higher overall for deaths caused by infectious diseases and diabetes, and lower for violent death and neoplasm). Moreover, mortality relative risks for male, violent deaths and cancer were positively associated with country-of-birth HDI, while female mortality and infectious disease mortality were negatively associated with country-of-birth HDI. Some important caveats have to be considered because the study did not control for individuals socioeconomic position in France, or length of residence in the host country. A strong healthy migrant effect was suggested and its intensity varies with age and gender (which may reflect different reasons for migration). For some specific causes of death, a lifestyle effect seems to explain mortality differentials. The associations between HDI and mortality show that mortality trends are partly related to the educational, sanitary and economic conditions of the country of birth. Further studies would enrich the differential analysis of mortality by country of birth by contributing additional detailed data on socioeconomic and living conditions in the host country as well as in the country of origin. DA - 2012/04// PY - 2012 DO - 10.1016/j.socscimed.2012.01.002 DP - NCBI PubMed VL - 74 IS - 8 SP - 1213 EP - 1223 J2 - Soc Sci Med LA - eng SN - 1873-5347 KW - Adolescent KW - Adult KW - Age Distribution KW - Aged KW - Asia KW - Asia, Central KW - Cause of Death KW - Child KW - Child, Preschool KW - Emigrants and Immigrants KW - Europe, Eastern KW - Female KW - France KW - Humans KW - Male KW - Middle Aged KW - Morocco KW - Mortality KW - Risk Assessment KW - Sex Distribution KW - United States KW - Urban Health KW - Young Adult ER - TY - JOUR TI - Migrant mortality from diabetes mellitus across Europe: the importance of socio-economic change AU - Vandenheede, Hadewijch AU - Deboosere, Patrick AU - Stirbu, Irina AU - Agyemang, Charles O AU - Harding, Seeromanie AU - Juel, Knud AU - Rafnsson, Snorri Björn AU - Regidor, Enrique AU - Rey, Grégoire AU - Rosato, Michael AU - Mackenbach, Johan P AU - Kunst, Anton E T2 - European journal of epidemiology AB - The first objective of this study was to determine and quantify variations in diabetes mortality by migrant status in different European countries. The second objective was to investigate the hypothesis that diabetes mortality is higher in migrant groups for whom the country of residence (COR) is more affluent than the country of birth (COB). We obtained mortality data from 7 European countries. To assess migrant diabetes mortality, we used direct standardization and Poisson regression. First, migrant mortality was estimated for each country separately. Then, we merged the data from all mortality registers. Subsequently, to examine the second hypothesis, we introduced gross domestic product (GDP) per capita of COB in the models, as an indicator of socio-economic circumstances. The overall pattern shows higher diabetes mortality in migrant populations compared to local-born populations. Mortality rate ratios (MRRs) were highest in migrants originating from either the Caribbean or South Asia. MRRs for the migrant population as a whole were 1.9 (95% CI 1.8-2.0) and 2.2 (95% CI 2.1-2.3) for men and women respectively. We furthermore found a consistently inverse association between GDP of COB and diabetes mortality. Most migrant groups have higher diabetes mortality rates than the local-born populations. Mortality rates are particularly high in migrants from North Africa, the Caribbean, South Asia or low-GDP countries. The inverse association between GDP of COB and diabetes mortality suggests that socio-economic change may be one of the key aetiological factors. DA - 2012/02// PY - 2012 DO - 10.1007/s10654-011-9638-6 DP - NCBI PubMed VL - 27 IS - 2 SP - 109 EP - 117 J2 - Eur. J. Epidemiol. LA - eng SN - 1573-7284 ST - Migrant mortality from diabetes mellitus across Europe KW - Adult KW - Aged KW - Diabetes Mellitus, Type 2 KW - Europe KW - Female KW - Humans KW - Male KW - Middle Aged KW - Social Class KW - Transients and Migrants KW - Young Adult ER - TY - JOUR TI - Mapping and predicting mortality from systemic sclerosis AU - Elhai, Muriel AU - Meune, Christophe AU - Boubaya, Marouane AU - Avouac, Jérôme AU - Hachulla, Eric AU - Balbir-Gurman, Alexandra AU - Riemekasten, Gabriela AU - Airò, Paolo AU - Joven, Beatriz AU - Vettori, Serena AU - Cozzi, Franco AU - Ullman, Susanne AU - Czirják, László AU - Tikly, Mohammed AU - Müller-Ladner, Ulf AU - Caramaschi, Paola AU - Distler, Oliver AU - Iannone, Florenzo AU - Ananieva, Lidia P. AU - Hesselstrand, Roger AU - Becvar, Radim AU - Gabrielli, Armando AU - Damjanov, Nemanja AU - Salvador, Maria J. AU - Riccieri, Valeria AU - Mihai, Carina AU - Szücs, Gabriella AU - Walker, Ulrich A. AU - Hunzelmann, Nicolas AU - Martinovic, Duska AU - Smith, Vanessa AU - Müller, Carolina de Souza AU - Montecucco, Carlo Maurizio AU - Opris, Daniela AU - Ingegnoli, Francesca AU - Vlachoyiannopoulos, Panayiotis G. AU - Stamenkovic, Bojana AU - Rosato, Edoardo AU - Heitmann, Stefan AU - Distler, Jörg H. W. AU - Zenone, Thierry AU - Seidel, Matthias AU - Vacca, Alessandra AU - Langhe, Ellen De AU - Novak, Srdan AU - Cutolo, Maurizio AU - Mouthon, Luc AU - Henes, Jörg AU - Chizzolini, Carlo AU - Mühlen, Carlos Alberto von AU - Solanki, Kamal AU - Rednic, Simona AU - Stamp, Lisa AU - Anic, Branimir AU - Santamaria, Vera Ortiz AU - Santis, Maria De AU - Yavuz, Sule AU - Sifuentes-Giraldo, Walter Alberto AU - Chatelus, Emmanuel AU - Stork, Jiri AU - Laar, Jacob van AU - Loyo, Esthela AU - García de la Peña Lefebvre, Paloma AU - Eyerich, Kilian AU - Cosentino, Vanesa AU - Alegre-Sancho, Juan Jose AU - Kowal-Bielecka, Otylia AU - Rey, Grégoire AU - Matucci-Cerinic, Marco AU - Allanore, Yannick AU - EUSTAR group T2 - Annals of the Rheumatic Diseases AB - OBJECTIVES: To determine the causes of death and risk factors in systemic sclerosis (SSc). METHODS: Between 2000 and 2011, we examined the death certificates of all French patients with SSc to determine causes of death. Then we examined causes of death and developed a score associated with all-cause mortality from the international European Scleroderma Trials and Research (EUSTAR) database. Candidate prognostic factors were tested by Cox proportional hazards regression model by single variable analysis, followed by a multiple variable model stratified by centres. The bootstrapping technique was used for internal validation. RESULTS: We identified 2719 French certificates of deaths related to SSc, mainly from cardiac (31%) and respiratory (18%) causes, and an increase in SSc-specific mortality over time. Over a median follow-up of 2.3 years, 1072 (9.6%) of 11 193 patients from the EUSTAR sample died, from cardiac disease in 27% and respiratory causes in 17%. By multiple variable analysis, a risk score was developed, which accurately predicted the 3-year mortality, with an area under the curve of 0.82. The 3-year survival of patients in the upper quartile was 53%, in contrast with 98% in the first quartile. CONCLUSION: Combining two complementary and detailed databases enabled the collection of an unprecedented 3700 deaths, revealing the major contribution of the cardiopulmonary system to SSc mortality. We also developed a robust score to risk-stratify these patients and estimate their 3-year survival. With the emergence of new therapies, these important observations should help caregivers plan and refine the monitoring and management to prolong these patients' survival. DA - 2017/08/23/ PY - 2017 DO - 10.1136/annrheumdis-2017-211448 DP - PubMed J2 - Ann. Rheum. Dis. LA - eng SN - 1468-2060 KW - cardiovascular disease KW - pulmonary fibrosis KW - systemic sclerosis ER - TY - JOUR TI - Innovations in medical care and mortality trends from four circulatory diseases between 1970 and 2005 AU - Hoffmann, Rasmus AU - Plug, Iris AU - McKee, Martin AU - Khoshaba, Bernadette AU - Westerling, Ragnar AU - Looman, Caspar AU - Rey, Gregoire AU - Jougla, Eric AU - Luis Alfonso, Jose AU - Lang, Katrin AU - Pärna, Kersti AU - Mackenbach, Johan P T2 - European journal of public health AB - BACKGROUND: Governments have identified innovation in pharmaceuticals and medical technology as a priority for health policy. Although the contribution of medical care to health has been studied extensively in clinical settings, much less is known about its contribution to population health. We examine how innovations in the management of four circulatory disorders have influenced trends in cause-specific mortality at the population level. METHODS: Based on literature reviews, we selected six medical innovations with proven effectiveness against hypertension, ischaemic heart disease, heart failure and cerebrovascular disease. We combined data on the timing of these innovations and cause-specific mortality trends (1970-2005) from seven European countries. We sought to identify associations between the introduction of innovations and favourable changes in mortality, using Joinpoint-models based on linear spline regression. RESULTS: For both ischaemic heart disease and cerebrovascular disease, the timing of medical innovations was associated with improved mortality in four out of five countries and five out of seven countries, respectively, depending on the innovation. This suggests that innovation has impacted positively on mortality at the population level. For hypertension and heart failure, such associations could not be identified. CONCLUSION: Although improvements in cause-specific mortality coincide with the introduction of some innovations, this is not invariably true. This is likely to reflect the incremental effects of many interventions, the time taken for them to be adopted fully and the presence of contemporaneous changes in disease incidence. Research on the impact of medical innovations on population health is limited by unreliable data on their introduction. DA - 2013/10// PY - 2013 DO - 10.1093/eurpub/ckt026 DP - NCBI PubMed VL - 23 IS - 5 SP - 852 EP - 857 J2 - Eur J Public Health LA - eng SN - 1464-360X ER - TY - JOUR TI - Impact of unemployment variations on suicide mortality in Western European countries (2000-2010): authors' reply AU - Laanani, Moussa AU - Ghosn, Walid AU - Jougla, Eric AU - Rey, Grégoire T2 - Journal of Epidemiology and Community Health DA - 2015/08// PY - 2015 DO - 10.1136/jech-2014-205382 DP - PubMed VL - 69 IS - 8 SP - 819 EP - 820 J2 - J Epidemiol Community Health LA - eng SN - 1470-2738 ST - Impact of unemployment variations on suicide mortality in Western European countries (2000-2010) KW - Female KW - Humans KW - Male KW - Mortality KW - Stress, Psychological KW - Suicide KW - Unemployment ER - TY - JOUR TI - Impact of unemployment variations on suicide mortality in Western European countries (2000-2010) AU - Laanani, Moussa AU - Ghosn, Walid AU - Jougla, Eric AU - Rey, Grégoire T2 - Journal of Epidemiology and Community Health AB - BACKGROUND: A scientific debate is currently taking place on whether the 2008 economic crisis caused an increase in suicide rates. Our main objective was to assess the impact of unemployment rate on suicide rate in Western European countries between 2000 and 2010. We then tried to estimate the excess number of suicides attributable to the increase of unemployment during the 2008-2010 economic crisis. METHODS: The yearly suicide rates were modelled using a quasi-Poisson model, controlling for sex, age, country and a linear time trend. For each country, the unemployment-suicide association was assessed, and the excess number of suicides attributable to the increase of unemployment was estimated. Sensitivity analyses were performed, notably in order to evaluate whether the unemployment-suicide association found was biased by a confounding context effect ('crisis effect'). RESULTS: A significant 0.3% overall increase in suicide rate for a 10% increase in unemployment rate (95% CI 0.1% to 0.5%) was highlighted. This association was significant in three countries: 0.7% (95% CI 0.0% to 1.4%) in the Netherlands, 1.0% (95% CI 0.2% to 1.8%) in the UK and 1.9% (95% CI 0.8% to 2.9%) in France, with a significant excess number of suicides attributable to unemployment variations between 2008 and 2010 (respectively 57, 456 and 564). The association was modified inconsistently when adding a 'crisis effect' into the model. CONCLUSIONS: Unemployment and suicide rates are globally statistically associated in the investigated countries. However, this association is weak, and its amplitude and sensitivity to the 'crisis effect' vary across countries. This inconsistency provides arguments against its causal interpretation. DA - 2015/02// PY - 2015 DO - 10.1136/jech-2013-203624 DP - PubMed VL - 69 IS - 2 SP - 103 EP - 109 J2 - J Epidemiol Community Health LA - eng SN - 1470-2738 KW - Adolescent KW - Adult KW - Age Distribution KW - Aged KW - Aged, 80 and over KW - Cross-Cultural Comparison KW - Economic Recession KW - Europe KW - Female KW - Humans KW - Male KW - Middle Aged KW - Mortality KW - Poisson Distribution KW - Risk KW - Sex Distribution KW - Stress, Psychological KW - Suicide KW - Unemployment KW - Young Adult ER - TY - JOUR TI - Hospital comparisons based on mortality: revisiting the choice of postadmission timeframe and evaluating the contribution of cause-of-death data, France, 2009 AU - Lamarche-Vadel, Agathe AU - Ngantcha, Marcus AU - Le Pogam, Marie-Annick AU - Ghosn, Walid AU - Grenier, Catherine AU - Meyer, Laurence AU - Rey, Grégoire T2 - Medical Care AB - BACKGROUND: In-hospital mortality is widely used to judge the quality of hospital care, but is biased by discharge patterns. Fixed-timeframe indicators have thus been recommended. However, the 30-day postadmission indicator may underestimate hospital-wide mortality, as patients dying in hospital >30 days after admission are considered as survivors. OBJECTIVES: To identify the most relevant timeframes and to assess the contribution of cause-of-death data. METHODS: The 2009 French hospital discharge database was linked to vital status records and to the causes of death register for 11.5 million hospital stays by beneficiaries of French general health insurance. Correlations and agreements between the 30-day hospital standardized mortality ratio (HSMR) and the in-hospital, 60-, 90-, 180-, and 365-day postadmission HSMRs were estimated. RESULTS: A total of 7.8%, 1.5%, and 0.5% of patients who died during their hospital stay were considered as survivors by the 30-, 60-, and 90-day HSMRs, respectively. The 30-day HSMR correlated strongly with the 60-day HSMR (Pearson coefficient=0.92), and their agreement on outlier status was excellent (κ coefficient=0.80). The association remained substantial at 90 days, but weakened at 180 days and even more so at 365 days. Regardless of the timeframe, exclusion of deaths likely due to independent causes barely modified the indicators. CONCLUSIONS: This nationwide study shows that 60- and 90-day HSMRs encompass in-hospital deaths better than the 30-day HSMR, while capturing the same interhospital variations. They should thus be preferred. The contribution of cause-of-death data to hospital-wide indicators seems negligible. DA - 2015/08// PY - 2015 DO - 10.1097/MLR.0000000000000376 DP - PubMed VL - 53 IS - 8 SP - 736 EP - 742 J2 - Med Care LA - eng SN - 1537-1948 ST - Hospital comparisons based on mortality KW - Cause of Death KW - Diagnosis-Related Groups KW - France KW - Hospital Mortality KW - Humans KW - Patient Admission KW - Patient Discharge KW - Quality Indicators, Health Care ER - TY - JOUR TI - Empirical comparison study of approximate methods for structure selection in binary graphical models AU - Viallon, Vivian AU - Banerjee, Onureena AU - Jougla, Eric AU - Rey, Grégoire AU - Coste, Joel T2 - Biometrical Journal. Biometrische Zeitschrift AB - Looking for associations among multiple variables is a topical issue in statistics due to the increasing amount of data encountered in biology, medicine, and many other domains involving statistical applications. Graphical models have recently gained popularity for this purpose in the statistical literature. In the binary case, however, exact inference is generally very slow or even intractable because of the form of the so-called log-partition function. In this paper, we review various approximate methods for structure selection in binary graphical models that have recently been proposed in the literature and compare them through an extensive simulation study. We also propose a modification of one existing method, that is shown to achieve good performance and to be generally very fast. We conclude with an application in which we search for associations among causes of death recorded on French death certificates. DA - 2014/03// PY - 2014 DO - 10.1002/bimj.201200253 DP - PubMed VL - 56 IS - 2 SP - 307 EP - 331 J2 - Biom J LA - eng SN - 1521-4036 KW - Binary graphical models KW - Biometry KW - Computer Graphics KW - Humans KW - Ising models KW - Likelihood Functions KW - Models, Statistical KW - Normal Distribution KW - Pseudo-likelihood KW - ℓ1 penalization ER - TY - JOUR TI - Do we really know the cause of death of the very old? Comparison between official mortality statistics and cohort study classification AU - Alpérovitch, Annick AU - Bertrand, Marion AU - Jougla, Eric AU - Vidal, Jean-Sébastien AU - Ducimetière, Pierre AU - Helmer, Catherine AU - Ritchie, Karen AU - Pavillon, Gérard AU - Tzourio, Christophe T2 - European journal of epidemiology AB - Causes of death of 625 subjects who died during the 4-year follow-up of a large population-based elderly cohort (Three-City study) were independently classified by the study adjudication committee and the national mortality register. The former used all available data about the cause of death (hospital records, medical data obtained from family physicians or specialists, and proxy interviews) and the latter used internationally standardized recommendations for processing death certificate data. Comparison showed a moderate overall agreement for underlying cause of death between the study adjudication committee and the national register (kappa = 0.51). Differences were found especially for cardiovascular diseases (20.6% of deaths from the study committee vs. 32.5% from the national register) and ill-defined causes of death (22.7 vs. 4%). The proportion of disagreement increased in participants dying at age >85 compared to those dying at age < or =70 (adjusted odds ratio = 2.46, 95% confidence interval = 1.10-5.49). It was also higher when the study committee used hospital record data for defining cause of death, compared to adjudication based on data obtained from proxy (adjusted odds ratio = 1.85, 95% CI = 1.09-3.14). These findings raise questions about the validity of national mortality registers in very old persons. Disease-specific causes of death, especially vascular diseases, could be overestimated in this age group. DA - 2009/// PY - 2009 DO - 10.1007/s10654-009-9383-2 DP - NCBI PubMed VL - 24 IS - 11 SP - 669 EP - 675 J2 - Eur. J. Epidemiol. LA - eng SN - 1573-7284 ST - Do we really know the cause of death of the very old? KW - Age Distribution KW - Age Factors KW - Aged KW - Aged, 80 and over KW - Cause of Death KW - Cohort Studies KW - Death Certificates KW - France KW - Humans KW - International Classification of Diseases KW - Male KW - Odds Ratio KW - Registries ER - TY - JOUR TI - Direct likelihood inference and sensitivity analysis for competing risks regression with missing causes of failure AU - Moreno-Betancur, Margarita AU - Rey, Grégoire AU - Latouche, Aurélien T2 - Biometrics AB - Competing risks arise in the analysis of failure times when there is a distinction between different causes of failure. In many studies, it is difficult to obtain complete cause of failure information for all individuals. Thus, several authors have proposed strategies for semi-parametric modeling of competing risks when some causes of failure are missing under the missing at random (MAR) assumption. As many authors have stressed, while semi-parametric models are convenient, fully-parametric regression modeling of the cause-specific hazards (CSH) and cumulative incidence functions (CIF) may be of interest for prediction and is likely to contribute towards a fuller understanding of the time-dynamics of the competing risks mechanism. We propose a so-called "direct likelihood" approach for fitting fully-parametric regression models for these two functionals under MAR. The MAR assumption not being verifiable from the observed data, we propose an approach for performing sensitivity analyses to assess the robustness of inferences to departures from this assumption. The method relies on so-called "pattern-mixture models" from the missing data literature and was evaluated in a simulation study. This sensitivity analysis approach is applicable to various competing risks regression models (fully-parametric or semi-parametric, for the CSH or the CIF). We illustrate the proposed methods with the analysis of a breast cancer clinical trial, including suggestions for ad hoc graphical goodness-of-fit assessments under MAR. DA - 2015/06// PY - 2015 DO - 10.1111/biom.12295 DP - PubMed VL - 71 IS - 2 SP - 498 EP - 507 J2 - Biometrics LA - eng SN - 1541-0420 KW - Cause-specific hazard KW - Competing risks KW - Cumulative incidence function KW - Missing at random KW - Missing cause of failure KW - Sensitivity analysis ER - TY - JOUR TI - Causes of deaths data, linkages and big data perspectives AU - Rey, Grégoire AU - Bounebache, Karim AU - Rondet, Claire T2 - Journal of Forensic and Legal Medicine AB - The study of cause-specific mortality data is one of the main sources of information for public health monitoring. In most industrialized countries, when a death occurs, it is a legal requirement that a medical certificate based on the international form recommended by World Health Organization's (WHO) is filled in by a physician. The physician reports the causes of death that directly led or contributed to the death on the death certificate. The death certificate is then forwarded to a coding office, where each cause is coded, and one underlying cause is defined, using the rules of the International Classification of Diseases and Related Health Problems, now in its 10th Revision (ICD-10). Recently, a growing number of countries have adopted, or have decided to adopt, the coding software Iris, developed and maintained by an international consortium1. This whole standardized production process results in a high and constantly increasing international comparability of cause-specific mortality data. While these data could be used for international comparisons and benchmarking of global burden of diseases, quality of care and prevention policies, there are also many other ways and methods to explore their richness, especially when they are linked with other data sources. Some of these methods are potentially referring to the so-called “big data” field. These methods could be applied both to the production of the data, to the statistical processing of the data, and even more to process these data linked to other databases. In the present note, we depict the main domains in which this new field of methods could be applied. We focus specifically on the context of France, a 65 million inhabitants country with a centralized health data system. Finally we will insist on the importance of data quality, and the specific problematics related to death certification in the forensic medicine domain. DA - 2016/12/29/ PY - 2016 DO - 10.1016/j.jflm.2016.12.004 DP - ScienceDirect J2 - Journal of Forensic and Legal Medicine SN - 1752-928X UR - http://www.sciencedirect.com/science/article/pii/S1752928X16301652 Y2 - 2017/09/28/12:12:50 KW - Causes of death data KW - Data linkages KW - big data ER - TY - JOUR TI - Cancer mortality patterns among Turkish immigrants in four European countries and in Turkey AU - Spallek, Jacob AU - Arnold, Melina AU - Razum, Oliver AU - Juel, Knud AU - Rey, Grégoire AU - Deboosere, Patrick AU - Mackenbach, Johan Pieter AU - Kunst, Anton Eduard T2 - European journal of epidemiology AB - The aim of this study on cancer mortality among Turkish immigrants, for the first time, traditional comparisons in migrant health research have been extended simultaneously in two ways. First, comparisons were made to cancer mortality from the immigrants' country of origin and second, cancer mortality among Turkish immigrants across four host countries (Belgium, Denmark, France and the Netherlands) was compared. Population-based cancer mortality data from these countries were included. Age-standardized mortality rates were computed for the local-born and Turkish population of each country. Relative differences in cancer mortality were examined by fitting country-specific Poisson regression models. Globocan data on cancer mortality in Turkey from 2008 were used in order to compare mortality rates of Turkish immigrants with those from their country of origin. Turkish immigrants had lower all-cancer mortality than the local-born populations of their host countries, and mortality levels comparable to all-cancer mortality rates in Turkey. In the Netherlands and France breast cancer mortality was consistently lower in Turkish immigrants women than among local-born women. Lung cancer mortality was slightly lower in Turkish immigrants in the Netherlands and France but varied considerably between migrants in these two host countries. Stomach cancer mortality was significantly higher in Turkish immigrants when compared to local-born French and Dutch. Our findings indicate that exposures both in the country of origin and in the host country can have an effect on the cancer mortality of immigrants. Despite limitations affecting any cross-country comparison of mortality, the innovative multi-comparison approach is a promising way to gain further insights into determinants of trends in cancer mortality of immigrants. DA - 2012/12// PY - 2012 DO - 10.1007/s10654-012-9746-y DP - NCBI PubMed VL - 27 IS - 12 SP - 915 EP - 921 J2 - Eur. J. Epidemiol. LA - eng SN - 1573-7284 KW - Adult KW - Age Distribution KW - Aged KW - Cause of Death KW - Emigrants and Immigrants KW - Ethnic Groups KW - Europe KW - Female KW - Health Surveys KW - Humans KW - Male KW - Middle Aged KW - Neoplasms KW - Poisson Distribution KW - Population Surveillance KW - Regression Analysis KW - Sex Distribution KW - Turkey ER - TY - JOUR TI - Association between Integration Policies and Immigrants' Mortality: An Explorative Study across Three European Countries AU - Ikram, Umar Z. AU - Malmusi, Davide AU - Juel, Knud AU - Rey, Grégoire AU - Kunst, Anton E. T2 - PloS One AB - BACKGROUND: To integrate immigrants into their societies, European countries have adopted different types of policies, which may influence health through both material and psychosocial determinants. Recent studies have suggested poorer health outcomes for immigrants living in countries with poorly rated integration policies. OBJECTIVE: To analyse mortality differences of immigrants from the same country of origin living in countries with distinct integration policy contexts. METHODS: From the mortality dataset collected in the Migrant Ethnic Health Observatory (MEHO) project, we chose the Netherlands (linked data from 1996-2006), France (unlinked; 2005-2007) and Denmark (linked; 1992-2001) as representatives of the inclusive, assimilationist and exclusionist policy models, respectively, based on the Migrant Integration Policy Index. We calculated for each country sex- and age-standardized mortality rates for Turkish-, Moroccan- and local-born populations aged 20-69 years. Poisson regression was used to estimate the mortality rate ratios (MRRs) for cross-country and within-country comparisons. The analyses were further stratified by age group and cause of death. RESULTS: Compared with their peers in the Netherlands, Turkish-born immigrants had higher all-cause mortality in Denmark (MRR men 1.92; 95% CI 1.74-2.13 and women 2.11; 1.80-2.47) but lower in France (men 0.64; 0.59-0.69 and women 0.58; 0.51-0.67). A similar pattern emerged for Moroccan-born immigrants. The relative differences between immigrants and the local-born population were also largest in Denmark and lowest in France (e.g., Turkish-born men MRR 1.52; 95% CI 1.38-1.67 and 0.62; 0.58-0.66, respectively). These patterns were consistent across all age groups, and more marked for cardiovascular diseases. CONCLUSIONS: Although confounders and data comparability issues (e.g., French cross-sectional data) may affect the findings, this study suggests that different macro-level policy contexts may influence immigrants' mortality. Comparable mortality registration systems across Europe along with detailed socio-demographic information on immigrants may help to better assess this association. DA - 2015/// PY - 2015 DO - 10.1371/journal.pone.0129916 DP - PubMed VL - 10 IS - 6 SP - e0129916 J2 - PLoS ONE LA - eng SN - 1932-6203 ST - Association between Integration Policies and Immigrants' Mortality ER - TY - JOUR TI - Are alcohol-attributable mortality estimates reliable? AU - Rey, Grégoire AU - Jougla, Eric T2 - European Journal of Public Health DA - 2014/02// PY - 2014 DO - 10.1093/eurpub/ckt114 DP - PubMed VL - 24 IS - 1 SP - 3 EP - 4 J2 - Eur J Public Health LA - eng SN - 1464-360X KW - Alcohol Drinking KW - Alcoholism KW - Female KW - Humans KW - Male KW - Mortality, Premature ER - TY - JOUR TI - All-cause and cause-specific mortality of different migrant populations in Europe AU - Ikram, Umar Z. AU - Mackenbach, Johan P. AU - Harding, Seeromanie AU - Rey, Grégoire AU - Bhopal, Raj S. AU - Regidor, Enrique AU - Rosato, Michael AU - Juel, Knud AU - Stronks, Karien AU - Kunst, Anton E. T2 - European Journal of Epidemiology AB - This study aimed to examine differences in all-cause mortality and main causes of death across different migrant and local-born populations living in six European countries. We used data from population and mortality registers from Denmark, England & Wales, France, Netherlands, Scotland, and Spain. We calculated age-standardized mortality rates for men and women aged 0-69 years. Country-specific data were pooled to assess weighted mortality rate ratios (MRRs) using Poisson regression. Analyses were stratified by age group, country of destination, and main cause of death. In six countries combined, all-cause mortality was lower for men and women from East Asia (MRRs 0.66; 95 % confidence interval 0.62-0.71 and 0.76; 0.69-0.82, respectively), and Other Latin America (0.44; 0.42-0.46 and 0.56; 0.54-0.59, respectively) than local-born populations. Mortality rates were similar for those from Turkey. All-cause mortality was higher in men and women from North Africa (1.09; 1.08-1.11 and 1.19; 1.17-1.22, respectively) and Eastern Europe (1.30; 1.27-1.33 and 1.05; 1.01-1.08, respectively), and women from Sub-Saharan Africa (1.34; 1.30-1.38). The pattern differed by age group and country of destination. Most migrants had higher mortality due to infectious diseases and homicide while cancer mortality and suicide were lower. CVD mortality differed by migrant population. To conclude, mortality patterns varied across migrant populations in European countries. Future research should focus both on migrant populations with favourable and less favourable mortality pattern, in order to understand this heterogeneity and to drive policy at the European level. DA - 2015/09/11/ PY - 2015 DO - 10.1007/s10654-015-0083-9 DP - PubMed J2 - Eur. J. Epidemiol. LA - ENG SN - 1573-7284 KW - All-cause mortality KW - Cause-specific mortality KW - Europe KW - Migrant health KW - Migrants ER - TY - JOUR TI - Acute pancreatitis as a cause of mortality in pediatric systemic lupus erythematosus: Results of a multiple cause-of-death analysis in France AU - Chiche, Laurent AU - Jourde-Chiche, Noémie AU - Bader-Meunier, Brigitte AU - Retornaz, Frederique AU - Malaekah, Sarah AU - Eb, Mireille AU - Rey, Gregoire AU - Belot, Alexandre T2 - Seminars in Arthritis and Rheumatism DA - 2016/03/16/ PY - 2016 DO - 10.1016/j.semarthrit.2016.03.009 DP - PubMed J2 - Semin. Arthritis Rheum. LA - ENG SN - 1532-866X ST - Acute pancreatitis as a cause of mortality in pediatric systemic lupus erythematosus ER - TY - CONF TI - Clef 2017 ehealth evaluation lab overview AU - Goeuriot, Lorraine AU - Kelly, Liadh AU - Suominen, Hanna AU - Névéol, Aurélie AU - Robert, Aude AU - Kanoulas, Evangelos AU - Spijker, Rene AU - Palotti, João AU - Zuccon, Guido C3 - International Conference of the Cross-Language Evaluation Forum for European Languages DA - 2017/// PY - 2017 DP - Google Scholar SP - 291 EP - 303 PB - Springer ER - TY - CONF TI - CLEF eHealth 2017 Multilingual Information Extraction task overview: ICD10 coding of death certificates in English and French AU - Névéol, Aurélie AU - Anderson, Robert N. AU - Cohen, K. Bretonnel AU - Grouin, Cyril AU - Lavergne, Thomas AU - Rey, Grégoire AU - Robert, Aude AU - Rondet, Claire AU - Zweigenbaum, Pierre C3 - CLEF 2017 Evaluation Labs and Workshop: Online Working Notes, CEUR-WS DA - 2017/// PY - 2017 DP - Google Scholar ST - CLEF eHealth 2017 Multilingual Information Extraction task overview ER - TY - JOUR TI - Comparison of the temperature-mortality relationship in foreign born and native born died in France between 2000 and 2009 AU - Mercereau, Luc AU - Todd, Nicolas AU - Rey, Gregoire AU - Valleron, Alain-Jacques T2 - International Journal of Biometeorology AB - The daily temperature-mortality relationship is typically U shaped. The temperature of minimum mortality (MMT) has been shown to vary in space (higher at lower latitudes) and time (higher in recent periods). This indicates human populations adapt to their local environment. The pace of this adaptation is unknown. The objective of this study was to investigate the differences in the temperature-mortality relationship in continental France between foreign born and natives. Source data were the 5,273,005 death certificates of individuals living in continental France between 2000 and 2009 at the time of their death. Foreign-born deaths (N = 573,384) were matched 1:1 with a native-born death based on date of birth, sex, and place of death. Four regions of France based on similarity of their temperatures profiles were defined by unsupervised clustering. For each of these four regions, variations of all causes mortality with season and temperature of the day were modeled and compared between four groups of foreign born (Maghreb, sub-Saharan Africa, Southern Europe, and Northern Europe) and matched groups of natives. Overall, the temperature-mortality relationship and MMT were close in foreign born and in native born: The only difference between foreign born and native born concerned the attributable mortality to cold, found in several instances larger in foreign born. There are little differences in France between the temperature-mortality relationships in native born and in foreign born. This supports the hypothesis of an adaptation of these populations to the temperature patterns of continental France, which for those born in Africa differ markedly from the climatic pattern of their birth country. DA - 2017/05/25/ PY - 2017 DO - 10.1007/s00484-017-1373-6 DP - PubMed J2 - Int J Biometeorol LA - eng SN - 1432-1254 KW - Adaptation KW - Climate change KW - Minimum mortality temperature KW - Mortality ER - TY - JOUR TI - Socio-economic factors associated with a healthy diet: results from the E3N study AU - Affret, Aurélie AU - Severi, Gianluca AU - Dow, Courtney AU - Rey, Grégoire AU - Delpierre, Cyrille AU - Boutron-Ruault, Marie-Christine AU - Clavel-Chapelon, Françoise AU - Fagherazzi, Guy T2 - Public Health Nutrition AB - OBJECTIVE: To identify individual and contextual socio-economic factors associated with a healthy diet. DESIGN: Dietary data from a large cohort study were used to derive two mutually exclusive dietary patterns through a latent class analysis. Associations between dietary patterns and socio-economic factors were studied with logistic regression. SETTING: E3N, a French prospective cohort study composed of women recruited from a national health insurance plan covering people working in the national education system. SUBJECTS: E3N participants (n 73 031) with dietary and socio-economic data available. RESULTS: The 'Healthy' pattern was characterized by a large consumption of fruits and vegetables and the 'Less Healthy' pattern by a large consumption of pizza and processed meat. When all socio-economic factors were analysed together, all of the individual factors considered were associated with a healthy diet (e.g. women with three or more children were less likely to follow a healthy diet v. women with no children, OR (95 % CI): 0·70 (0·66, 0·75)) while the contextual factors associated with a healthy diet included the size of the agglomeration of residence and the area of birth and residence (e.g. women living in the West of France were less likely to follow a healthy diet v. those living in the South of France: 0·78 (0·72, 0·83)). CONCLUSIONS: We demonstrated that individual and contextual factors are both associated with diet. Rather than focusing only on individual factors, we recommend future studies or public health and nutritional strategies on diet to consider both types of factors. DA - 2017/06// PY - 2017 DO - 10.1017/S1368980017000222 DP - PubMed VL - 20 IS - 9 SP - 1574 EP - 1583 J2 - Public Health Nutr LA - eng SN - 1475-2727 ST - Socio-economic factors associated with a healthy diet KW - A posteriori patterns KW - Diet KW - E3N cohort KW - Latent class analysis KW - Socio-economic environment KW - methodology ER - TY - JOUR TI - Mortality profile of patients with rheumatoid arthritis in France and its change in 10 years AU - Avouac, Jérôme AU - Amrouche, Fazia AU - Meune, Christophe AU - Rey, Grégoire AU - Kahan, André AU - Allanore, Yannick T2 - Seminars in Arthritis and Rheumatism AB - OBJECTIVE: To study the mortality profile of patients with rheumatoid arthritis (RA) in France. METHODS: Data were collected between 2000 and 2011 from the French Epidemiological Center for the Medical Causes of Death database; all death certificates from adults that either mentioned RA as an underlying cause of death (UCD) or as an associated cause of death (ACD) were evaluated using multiple-cause-of-death analysis. The different causes of death and their frequency were reported, together with the ratio of observed/expected number of death (O/E ratio) to measure the strength of association between RA listed as an ACD and the corresponding UCD. RESULTS: During the study period, 13,208 deaths related to RA were identified. The mean ± SD age at death was 79 ± 9 years (51% with ≥80 years) and the female/male ratio was 3.2. When RA was the UCD (n = 4597), the main causes of death were cardiovascular (29%) and infectious diseases (22%). When RA was an ACD (n = 8611), the most common UCDs were cardiovascular diseases (35%), neoplasms (14%), respiratory disease (9%), and infectious diseases (7%). The overall O/E ratio was >1 for infectious (3.58), respiratory (1.38), and cardiovascular diseases (1.25), but was TY - JOUR TI - Hospital quality measures: are process indicators associated with hospital standardized mortality ratios in French acute care hospitals? AU - Ngantcha, Marcus AU - Le-Pogam, Marie-Annick AU - Calmus, Sophie AU - Grenier, Catherine AU - Evrard, Isabelle AU - Lamarche-Vadel, Agathe AU - Rey, Grégoire T2 - BMC health services research AB - BACKGROUND: Results of associations between process and mortality indicators, both used for the external assessment of hospital care quality or public reporting, differ strongly across studies. However, most of those studies were conducted in North America or United Kingdom. Providing new evidence based on French data could fuel the international debate on quality of care indicators and help inform French policy-makers. The objective of our study was to explore whether optimal care delivery in French hospitals as assessed by their Hospital Process Indicators (HPIs) is associated with low Hospital Standardized Mortality Ratios (HSMRs). METHODS: The French National Authority for Health (HAS) routinely collects for each hospital located in France, a set of mandatory HPIs. Five HPIs were selected among the process indicators collected by the HAS in 2009. They were measured using random samples of 60 to 80 medical records from inpatients admitted between January 1st, 2009 and December 31, 2009 in respect with some selection criteria. HSMRs were estimated at 30, 60 and 90 days post-admission (dpa) using administrative health data extracted from the national health insurance information system (SNIIR-AM) which covers 77% of the French population. Associations between HPIs and HSMRs were assessed by Poisson regression models corrected for measurement errors with a simulation-extrapolation (SIMEX) method. RESULTS: Most associations studied were not statistically significant. Only two process indicators were found associated with HSMRs. Completeness and quality of anesthetic records was negatively associated with 30 dpa HSMR (0.72 [0.52-0.99]). Early detection of nutritional disorders was negatively associated with all HSMRs: 30 dpa HSMR (0.71 [0.54-0.95]), 60 dpa HSMR (0.51 [0.39-0.67]) and 90 dpa HSMR (0.52 [0.40-0.68]). CONCLUSION: In absence of gold standard of quality of care measurement, the limited number of associations suggested to drive in-depth improvements in order to better determine associations between process and mortality indicators. A smart utilization of both process and outcomes indicators is mandatory to capture aspects of the hospital quality of care complexity. DA - 2017/08/22/ PY - 2017 DO - 10.1186/s12913-017-2534-3 DP - PubMed VL - 17 IS - 1 SP - 578 J2 - BMC Health Serv Res LA - eng SN - 1472-6963 ST - Hospital quality measures KW - Hospital Process Indicators KW - Hospital Standardized Mortality Ratio KW - Quality of care KW - SIMEX method ER - TY - JOUR TI - Associations of cause-specific mortality with area level deprivation and travel time to health care in France from 1990 to 2007, a multilevel analysis AU - Ghosn, Walid AU - Menvielle, Gwenn AU - Rican, Stéphane AU - Rey, Grégoire T2 - BMC public health AB - BACKGROUND: It is now widely accepted that social and physical environment participate in shaping health. While mortality is used to guide public health policies and is considered as a synthetic measure of population health, few studies deals with the contextual features potentially associated with mortality in a representative sample of an entire country. This paper investigates the possible role of area deprivation (FDep99) and travel time to health care on French cause-specific mortality in a proper multilevel setting. METHODS: The study population was a 1% sample representative of the French population aged from 30 to 79 years in 1990 and followed up until 2007. A frailty Cox model was used to measure individual, contextual effects and spatial variances for several causes of death. The chosen contextual scale was the Zone d'Emploi of 1994 (348 units) which delimits the daily commute of people. The geographical accessibility to health care score was constructed with principal component analysis, using 40 variables of hospital specialties and health practitioners' travel time. RESULTS: The outcomes highlight a positive and significant association between area deprivation and mortality for all causes (HR = 1.24), cancers, cerebrovascular diseases, ischemic heart diseases, and preventable and amenable diseases (HR from 1.14 to 1.29). These contextual associations exhibit no substantial differences by sex except for premature ischemic heart diseases mortality which was much greater in women. Unexpectedly, mortality decreased as the time to reach health care resources increased. Only geographical disparities in cerebrovascular and ischemic heart diseases mortality were explained by compositional and contextual effects. DISCUSSION: The findings suggest the presence of confounding factors in the association between mortality and travel time to health care, possibly owing to population density and health-selected migration. Although the spatial scale considered to define the context of residence was relatively large, the associations with area deprivation were strong in comparison to the existing literature and significant for almost all the causes of deaths investigated. CONCLUSION: The broad spectrum of diseases associated with area deprivation and individual education support the idea of a need for a global health policy targeting both individual and territories to reduce social and socio-spatial inequalities. DA - 2017/08/02/ PY - 2017 DO - 10.1186/s12889-017-4562-7 DP - PubMed VL - 18 IS - 1 SP - 86 J2 - BMC Public Health LA - eng SN - 1471-2458 KW - Cause-specific mortality KW - Contextual association KW - Deprivation KW - Geographical mortality disparities KW - Travel time to health care ER - TY - JOUR TI - Fatal anaphylaxis in France: analysis of national anaphylaxis data, 1979-2011 AU - Pouessel, Guillaume AU - Claverie, Claire AU - Labreuche, Julien AU - Dorkenoo, Aimée AU - Renaudin, Jean-Marie AU - Eb, Mireille AU - Lejeune, Stéphanie AU - Deschildre, Antoine AU - Leteurtre, Stéphane T2 - The Journal of Allergy and Clinical Immunology AB - The anaphylaxis mortality rate has fallen about 2% per year in France over the past 3 decades. Increased awareness of anaphylaxis treatment guidelines will hopefully continue this trend. DA - 2017/03/07/ PY - 2017 DO - 10.1016/j.jaci.2017.02.014 DP - PubMed J2 - J. Allergy Clin. Immunol. LA - eng SN - 1097-6825 ST - Fatal anaphylaxis in France KW - Anaphylaxis KW - drug allergy KW - fatalities KW - food allergy KW - iatrogenic KW - mortality rate KW - venom insect allergy ER - TY - JOUR TI - Pertinence of electronic death certificates for real-time surveillance and alert, France, 2012–2014 AU - Lassalle, M. AU - Caserio-Schönemann, C. AU - Gallay, A. AU - Rey, G. AU - Fouillet, A. T2 - Public Health AB - Objectives In France, the early mortality monitoring, conducted by Santé publique France, the French National Public Health agency (SpFrance) (formerly French Institute for public health surveillance-InVS), is based on the administrative data provided by the National Institute for Statistic and Economic Studies (INSEE) and consequently does not allow analyses on medical causes of death. Since 2007, the physicians can certify deaths electronically. In this electronic system (Electronic Death Registration System; EDRS), the medical causes of death, in free-text format, are directly transmitted to SpFrance. In the future, these data could be used in a real-time surveillance system by medical causes of death. The objective of this study was to evaluate the pertinence of e-death certification using the following assessment criteria: timeliness, representativeness, and completeness of sociodemographic and medical information included in the e-death certificates. Study design This study consisted of a descriptive analysis of the information collected by e-death certificates recorded between January 1, 2012 and July 31, 2014. Methods The study quantified the temporal and geographical evolution of the deployment of the EDRS between 2012 and 2014. The timeliness of the system was estimated by calculating the delay between the dates of death and of data availability for analysis. Sociodemographic and death-related characteristics were described. The frequency of missing data was measured for each variable. The number of completed fields per certificate and the number of words per field and per certificate were calculated for the medical causes of death. Results Between January 2012 and July 2014, 77,776 e-death certificates were collected. A slight increase in the use of the e-death certification was observed during the study period, reaching 6.1% of the total number of deaths in 2014. Good national coverage was noted. Nearly 79% of e-certificates were submitted to SpFrance on the day of the death. We observed a high completeness of the e-certificates. The rate of missing data did not exceed 2.7% for sociodemographic variables. On average, 10 words, distributed in three fields, were used to describe the medical causes of death. Conclusions E-death certificates constitute a reactive source of information on medical causes of death. The deployment of EDRS is of major public health interest for the development of a real-time warning surveillance system of mortality by cause. DA - 2017///février PY - 2017 DO - 10.1016/j.puhe.2016.10.029 DP - ScienceDirect VL - 143 SP - 85 EP - 93 J2 - Public Health SN - 0033-3506 UR - http://www.sciencedirect.com/science/article/pii/S0033350616303821 Y2 - 2016/12/13/17:07:21 KW - Free-text KW - Medical causes of death KW - Mortality KW - SurSaUD KW - Syndromic surveillance ER - TY - JOUR TI - Survival Analysis with Multiple Causes of Death: Extending the Competing Risks Model AU - Moreno-Betancur, Margarita AU - Sadaoui, Hamza AU - Piffaretti, Clara AU - Rey, Grégoire T2 - Epidemiology (Cambridge, Mass.) AB - Statistics on mortality related to each disease are usually based on the so-called underlying cause of death, which is selected from the diseases declared on the standardized death certificate using international rules. However, the assumption that each death is caused by exactly one disease is debatable, particularly with an aging population in an era where infectious diseases are replaced by chronic and degenerative diseases. The need to consider multiple causes of death has been acknowledged in epidemiologic research, with a growing body of literature producing statistics based on any mention of a disease on the death certificate. Yet there has not been a formal framework proposed for the statistical modeling of death arising from multiple causes. We propose a model for multiple cause of death data grounded on an empirical approach that assigns weights to each cause on the death certificate. We describe how this model for multiple-cause mortality, which extends the usual competing risks model used to conceptualize single-cause mortality, can serve to study the burden and etiology of mortality related to each disease, particularly using Cox regression methodology. We discuss how the multiple-cause, single-cause, and "any-mention" approaches compare in this regard. A simulation study and an application to a study of socioeconomic inequalities in mortality show the value of the proposed methods for exploiting this precious source of data to gain new insights, especially for certain diseases. See video abstract at, http://links.lww.com/EDE/B84. DA - 2017/01// PY - 2017 DO - 10.1097/EDE.0000000000000531 DP - PubMed VL - 28 IS - 1 SP - 12 EP - 19 J2 - Epidemiology LA - eng SN - 1531-5487 ST - Survival Analysis with Multiple Causes of Death ER - TY - CONF TI - A Dataset for ICD-10 Coding of Death Certificates: Creation and Usage AU - Lavergne, Thomas AU - Névéol, Aurélie AU - Robert, Aude AU - Grouin, Cyril AU - Rey, Grégoire AU - Zweigenbaum, Pierre T2 - BioTxtM DA - 2016/10/25/ PY - 2016 ER - TY - JOUR TI - Les données des certificats de décès en France : processus de production et principaux types d’analyse AU - Rey, G. T2 - La Revue de Médecine Interne AB - Résumé Les données de mortalité, par le peu d’ambiguïté de leur définition, leur compréhension par l’ensemble des acteurs, et l’exhaustivité de leur enregistrement, constituent une pierre angulaire de la statistique en santé publique en France et dans la plupart des pays industrialisés. Cet article décrit le processus de production des données et les principaux types d’analyses possibles. La production des données se décompose en différentes étapes : la certification par le médecin sur support papier ou électronique (à l’aide d’une application web), la transmission des données à l’Inserm, la saisie et le codage de l’information. Le codage de l’information vise à suivre les recommandations de l’OMS formulées dans la Classification internationale des maladies ([CIM], 10e révision utilisée depuis 2000). Il est effectué à l’aide d’un logiciel de codage automatique, nommé Iris, développé au sein d’un consortium international. Le codage consiste en premier lieu à attribuer un code de la CIM à toutes les entités nosologiques rencontrées sur le certificat, puis à choisir la cause initiale de décès. Cette dernière est la principale information utilisée pour les exploitations statistiques. Trois principaux types d’analyses se dégagent dans la littérature : l’exploitation des données présentes sur le certificat de décès uniquement, les analyses écologiques (études d’associations entre des variables mesurées à l’échelle de groupes) et les analyses à partir de données chaînées individuellement à d’autres bases de données. Ces différentes analyses permettent de traiter de nombreuses problématiques en santé publique. Plusieurs évolutions dans le processus de production sont en cours de mise en œuvre : le déploiement de la certification électronique, l’automatisation accrue du traitement de l’information contenue sur les certificats et le chaînage pérenne et complet de l’information avec les données de l’assurance maladie et d’hospitalisation. Elles pourraient prochainement élargir encore le champ des exploitations possibles des données de causes de décès. Mortality data, by the unambiguity of their definition and understanding by all stakeholders, and completeness of registration, are a cornerstone of public health statistics in France and in most industrialized countries. This article describes the data production process, and the main types of possible analyses. Data production is composed of different stages: death certification by a medical doctor on paper or electronic (using a web application) format, data transmission to Inserm, capture and coding of information. The encoding of the information follows the WHO recommendations of the International Classification of Diseases ([ICD], 10th revision used since 2000). It is carried out using an automatic coding software, called Iris, developed in an international consortium. The coding aims, first, at assigning an ICD code to all nosologic entities encountered on the certificate, and then at selecting the underlying cause of death. The latter is the main information used for statistical analyses. Three main types of analysis emerge in the literature: the exploitation of data on the death certificate only, ecological analyses (studies of associations between variables measured across groups) and analysis from data individually linked to other databases. Many public health issues can be addressed with these various analyses. Several developments in the production process are being implemented: the deployment of electronic certification, increased automation of the death certificate information processing and durable and complete record linkage with health insurance and hospitalisation data. They could soon be deeply expanding the scope of possible uses of causes of death data. DA - 2016/10/01/ PY - 2016 DO - 10.1016/j.revmed.2016.01.011 DP - ScienceDirect VL - 37 IS - 10 SP - 685 EP - 693 J2 - La Revue de Médecine Interne SN - 0248-8663 ST - Les données des certificats de décès en France UR - http://www.sciencedirect.com/science/article/pii/S0248866316000424 Y2 - 2018/05/14/13:33:49 KW - Causes de décès KW - Codage médical KW - Medical coding KW - National statistics KW - Public health KW - Santé publique KW - Statistique nationale ER - TY - JOUR TI - État des lieux des pratiques et de la rédaction des certificats de décès par les instituts médicolégaux en France, en 2016, dans la perspective de la mise en place d’un volet complémentaire du certificat de décès AU - Richaud-Eyraud, E. AU - Gigonzac, V. AU - Rondet, C. AU - Khireddine-Medouni, I. AU - Chan-Chee, C. AU - Chérié-Challine, L. AU - Ludes, B. AU - Rey, G. T2 - La Revue de Médecine Légale AB - Résumé But de l’étude Faire l’état des lieux des pratiques et de la rédaction des certificats de décès par les instituts médicolégaux, notamment en cas de suicide, dans la perspective de la mise en place d’un volet complémentaire du certificat de décès. Méthodes Durant l’année 2016, une enquête téléphonique a été réalisée, par Santé publique France et l’Inserm, auprès de l’ensemble des IML français. Le questionnaire concernait les activités au sein de l’IML, les modalités d’organisation et d’enregistrement des données, ainsi que les pratiques de certification des décès. Résultats Trente IML ont participé à l’enquête. En cas de suspicion de suicide, un IML sur six a estimé que la réalisation d’une autopsie était systématique ou très fréquente. Un grand nombre d’IML a informatisé leurs données et codé les causes de décès. Les principaux freins à la certification des décès ont été : la non-compréhension de la pertinence de cette pratique (46 %), la crainte de doublonner les déclarations de décès et de fausser les statistiques de mortalité (27 %), le refus de lever l’obstacle médicolégal à la place du magistrat (15 %) et la méconnaissance de l’intérêt de cette information en santé publique (11 %). Conclusion Ce travail a montré qu’il était nécessaire d’homogénéiser les pratiques des IML afin d’améliorer la qualité des données médicolégales pour une utilisation en santé publique. Il a souligné l’importance de mettre rapidement en circulation le volet médical complémentaire qui pourrait à terme intégrer des données spécifiques sur les suicides. Summary Aim An overview on forensic institutes’ practices and drafting of death certificates, in particular in case of suicide, was realized with the aim to implement a supplementary form to the death certificate. Methods A phone survey was conducted in 2016 with French forensic institutes by Santé publique France and Inserm. The questionnaire was focused on forensic institutes’ activities, organization, data recording and death certification. Results Thirty forensic institutes participated. In case of suspicion of suicide, one forensic institute in six estimated that an autopsy is always or very often conducted. Numerous forensic institutes computerized data and coded causes of death. Main limitations to complete death certificates were: the lack of understanding of the relevance of this practice (46 %), the worry to duplicate notifications of deaths and to bias mortality statistics (27 %), the refusal to remove forensic obstacle instead of the magistrate (15 %), the ignorance of the interest for public health (11 %). Conclusions This study underlined the necessity to homogenise forensic institutes’ practices in order to improve the quality of forensic data for use in public health. It emphasized the urgent need of a complementary form to the death certificate, which could add specific information on suicides. DA - 2018/02/01/ PY - 2018 DO - 10.1016/j.medleg.2017.11.001 DP - ScienceDirect VL - 9 IS - 1 SP - 1 EP - 9 J2 - La Revue de Médecine Légale SN - 1878-6529 UR - http://www.sciencedirect.com/science/article/pii/S1878652917301220 Y2 - 2018/05/14/13:26:37 KW - Autopsie KW - Autopsy KW - Cause de décès KW - Certificats de décès KW - Forensic medecine KW - Médecine légale KW - Suicide ER - TY - JOUR TI - Associations entre niveau socioéconomique et recours aux soins des personnes diabétiques, et évolutions entre 2001 et 2007, à partir d’une approche écologique. Enquêtes Entred 2001 et 2007, France AU - Fosse-Edorh, Sandrine AU - Pornet, Carole AU - Delpierre, Cyrille AU - Rey, Grégoire AU - Bihan, Hélène AU - Fagot-Campagna, Anne T2 - Bull Epidemio Hebdo DA - 2014/// PY - 2014 VL - 30-31 ER - TY - JOUR TI - Analyse de la mortalité par cause : pondération des causes multiples AU - Rey, Grégoire AU - Piffaretti, Clara AU - Rondet, Claire AU - Lamarche-Vadel, Agathe AU - Moreno-Betancur, Margarita T2 - Bul Epidémiol Hebd AB - Objectif L’analyse des données de mortalité est essentielle à l’observation en santé publique. Dans un contexte où les décès sont souvent attribuables à plusieurs maladies, cet article présente une nouvelle méthode permettant de réévaluer les taux standardisés de mortalité par cause, en considérant plusieurs causes par décès. Méthode À partir des données de la base nationale des causes de décès en 2010, nous avons calculé des taux standardisés de mortalité par cause en utilisant : la cause initiale de décès et deux stratégies de pondération des causes multiples (PCM), qui attribuent un poids aux différentes causes mentionnées sur le certificat de décès. Pour chaque décès, la somme des poids est égale à 1. Ainsi, l’influence de chaque décès sur les taux de mortalité reste la même. Les variations relatives des taux standardisés de mortalité selon les deux stratégies PCM par rapport aux taux obtenus avec la méthode en cause initiale ont été calculées. Résultats L’utilisation d’une stratégie de pondération modifiait sensiblement la distribution des taux standardisés par cause. La variation relative du taux standardisé de mortalité obtenue avec la seconde stratégie PCM était supérieure à 20% pour cinq catégories de maladies : maladies génito-urinaires, hématologiques, endocriniennes, dermatologiques et troubles mentaux. Conclusion Cette nouvelle méthode de pondération permet d’exploiter en totalité les causes médicales du certificat de décès pour tenir compte du caractère pluricausal de la mortalité et d’obtenir ainsi des indicateurs de mortalité par cause plus pertinents pour la santé publique. DA - 2017/10/01/ PY - 2017 IS - 1 SP - 13 EP - 19 ER - TY - JOUR TI - Déterminants de la mortalité des personnes diabétiques de type 2. Cohortes Entred, 2002 – 2013. AU - Piffaretti, Clara AU - Fagot-Campagna, Anne AU - Rey, Grégoire AU - Antero-Jacquemin, Juliana AU - Latouche, Aurélien AU - Mandereau-Bruno, L. AU - Fosse-Edorh, Sandrine T2 - Bull Epidémiol Hebd DA - 2016/// PY - 2016 ER - TY - JOUR TI - Surmortalité sur la période 2002-2011 des personnes diabétiques traitées pharmacologiquement en France métropolitaine par rapport à la population générale - cohorte Entred 2001 AU - Mandereau-Bruno, L. AU - Fagot-Campagna, Anne AU - Rey, Grégoire AU - Piffaretti, Clara AU - Antero-Jacquemin, Juliana AU - Latouche, Aurélien AU - Fosse-Edorh, Sandrine T2 - Bull Epidémiol Hebd DA - 2016/// PY - 2016 ER - TY - JOUR TI - Evolution de la mortalité et de la surmortalité à 5 ans des personnes diabétiques traitées pharmacologiquement en France métropolitaine : comparaison des cohortes Entred 2001 et Entred 2007 AU - Mandereau-Bruno, L. AU - Fagot-Campagna, Anne AU - Rey, Grégoire AU - Piffaretti, Clara AU - Antero-Jacquemin, Juliana AU - Latouche, Aurélien AU - Fosse-Edorh, Sandrine T2 - Bull Epidémiol Hebd DA - 2016/// PY - 2016 ER - TY - JOUR TI - L'accès aux données massives de santé AU - Grimaud, Olivier AU - Le Meur, Nolwenn AU - Oger, Emmanuel AU - Rey, Grégoire T2 - Les cahiers de la fonction publique DA - 2016/09// PY - 2016 IS - 369 ER - TY - JOUR TI - Association entre taux de chômage et suicide, par sexe et classe d’âge, en France métropolitaine, 2000-2010 AU - Laanani, Moussa AU - Ghosn, Walid AU - Jougla, Eric AU - Rey, Grégoire T2 - Bul Epidémiol Hebd DA - 2015/01// PY - 2015 VL - 1-2 SP - 2 EP - 6 J2 - Bul Epidemiol Hebd LA - fr ER - TY - JOUR TI - Les causes de décès en Polynésie française : analyse de la période 2005-2010 et tendances évolutives de 1984 à 2010 AU - Yen Kai Sun, Laure AU - Ghosn, Walid AU - Rey, Grégoire T2 - Bul Epidémiol Hebd DA - 2016/// PY - 2016 VL - 10 SP - 183 EP - 95 ER - TY - JOUR TI - [Death certificate data in France: Production process and main types of analyses] AU - Rey, G. T2 - La Revue De Medecine Interne / Fondee ... Par La Societe Nationale Francaise De Medecine Interne AB - Mortality data, by the unambiguity of their definition and understanding by all stakeholders, and completeness of registration, are a cornerstone of public health statistics in France and in most industrialized countries. This article describes the data production process, and the main types of possible analyses. Data production is composed of different stages: death certification by a medical doctor on paper or electronic (using a web application) format, data transmission to Inserm, capture and coding of information. The encoding of the information follows the WHO recommendations of the International Classification of Diseases ([ICD], 10th revision used since 2000). It is carried out using an automatic coding software, called Iris, developed in an international consortium. The coding aims, first, at assigning an ICD code to all nosologic entities encountered on the certificate, and then at selecting the underlying cause of death. The latter is the main information used for statistical analyses. Three main types of analysis emerge in the literature: the exploitation of data on the death certificate only, ecological analyses (studies of associations between variables measured across groups) and analysis from data individually linked to other databases. Many public health issues can be addressed with these various analyses. Several developments in the production process are being implemented: the deployment of electronic certification, increased automation of the death certificate information processing and durable and complete record linkage with health insurance and hospitalisation data. They could soon be deeply expanding the scope of possible uses of causes of death data. DA - 2016/02/17/ PY - 2016 DO - 10.1016/j.revmed.2016.01.011 DP - PubMed J2 - Rev Med Interne LA - fr SN - 1768-3122 ST - [Death certificate data in France KW - Causes de décès KW - Codage médical KW - Medical coding KW - National statistics KW - Public health KW - Santé publique KW - Statistique nationale ER - TY - JOUR TI - Les causes de décès en Polynésie française : Analyse de la période 2005-2010 et tendances évolutives de 1984 à 2010 AU - Yen Kai Sun, Laure AU - Ghosn, Walid AU - Rey, Grégoire T2 - Bulletin d'Informations Sanitaires, Epidémiologiques et Statistiques DA - 2014///Février PY - 2014 VL - 10 J2 - BISES ST - Les causes de décès en Polynésie française UR - http://documentation.outre-mer.gouv.fr/Record.htm?record=19126576124919447589&idlist=1 Y2 - 2014/10/08/06:27:35 KW - MALADIE KW - MORTALITE KW - POLYNESIE FRANCAISE KW - SANTE PUBLIQUE KW - statistique ER - TY - JOUR TI - Comment mesure-t-on les causes de décès en France ? AU - Rey, Grégoire AU - Lamarche-Vadel, Agathe AU - Jougla, Eric T2 - Question de santé publique DA - 2013///Juillet PY - 2013 IS - 21 SP - 1 EP - 4 ER - TY - JOUR TI - Mortalité coronaire et hospitalisations pour IDM : tendances nationales 2002-2008. AU - de Peretti, Christine AU - Chin, Francis AU - Tuppin, Philippe AU - Rey, Grégoire AU - Jougla, Eric AU - Danchin, Nicolas T2 - Consensus Cardio DA - 2013/// PY - 2013 IS - 85 SP - 14 EP - 16 ER - TY - JOUR TI - Evaluation de la qualité des certificats de décès français en France : l'apport de la certification électronique AU - Lefeuvre, Delphine AU - Pavillon, Gérard AU - Lamarche-Vadel, Agathe AU - Fouillet, Anne AU - Aouba, Albertine AU - Jougla, Eric AU - Rey, Grégoire T2 - Bull Epidemio Hebdo DA - 2013/// PY - 2013 IS - 7 SP - 57 EP - 60 ER - TY - JOUR TI - L'évolution de la mortalité et des causes de décès entre 1990 et 2009. AU - Aouba, Albertine AU - Jougla, Eric AU - Eb, Mireille AU - Rey, Grégoire T2 - Actualité et dossier de santé publique DA - 2012/// PY - 2012 IS - 80 SP - 24 EP - 8 ER - TY - JOUR TI - Causes de décès des patients infectés par le VIH en France en 2010 (étude ANRS EN20 Mortalité 2010). AU - Roussillon, Caroline AU - Hénard, S AU - Hardel, L AU - Rosenthal, Eric AU - Aouba, Albertine AU - Bonnet, Fabrice AU - Couturier, F AU - Cacoub, Patrice AU - May, Thierry AU - Salmon, Dominique AU - Chêne, Geneviève AU - Morlat, Philippe T2 - Bull Epidemio Hebdo DA - 2012/// PY - 2012 IS - 46-47 SP - 541 EP - 5 ER - TY - JOUR TI - Où meurt-on en France? Analyse des certificats de décès (1993-2008) AU - Gisquet, Elsa AU - Aouba, Albertine AU - Aubry, Régis AU - Jougla, Eric AU - Rey, Grégoire T2 - Bull Epidemio Hebdo DA - 2012/12// PY - 2012 DP - Google Scholar IS - 48 SP - 547 EP - 551 ST - Où meurt-on en France? UR - http://e-deal.biz/file/Mf/common/BEH_48_2012_Vweb.pdf Y2 - 2013/09/27/10:23:18 ER - TY - JOUR TI - La mortalité infantile dans les départements français d’outre-mer (2000-2008) AU - Boulogne, Roxane AU - Gonzales, Lucie AU - Aouba, Albertine AU - Danet, Sandrine AU - Jougla, Eric AU - Rey, Grégoire T2 - Etudes et résultats DA - 2012/// PY - 2012 IS - 808 ER - TY - JOUR TI - Surveillance de la mortalité au cours de l’hiver 2011-2012 en France AU - Fouillet, Anne AU - Merlen, Richard AU - Rey, Grégoire AU - Cardoso, Thierry AU - Caserio-Schnönemann, Céline T2 - Bull Epidemio Hebdo DA - 2012/// PY - 2012 DP - Google Scholar UR - http://quoi.info/wp-content/uploads/2012/09/Bulletin-de-lINVS-sur-la-mortalite-au-cours-de-lhiver-2011-2012.pdf Y2 - 2013/09/27/09:34:16 ER - TY - JOUR TI - La certification électronique des décès, France, 2007-2011 AU - Fouillet, A. AU - Pavillon, G. AU - Vicente, P. AU - Caillère, N. AU - Aouba, A. AU - Jougla, E. AU - Rey, G. T2 - Bull Epidemio Hebdo DA - 2012/// PY - 2012 DP - Google Scholar VL - 1 SP - 7 EP - 10 ER - TY - JOUR TI - Évaluation de la qualité et amélioration de la connaissance des données de mortalité par suicide en France métropolitaine, 2006 AU - Aouba, Albertine AU - Péquignot, Françoise AU - Camelin, Laurence AU - Jougla, Eric T2 - Bul Epidémiol Hebd DA - 2011/// PY - 2011 IS - 47-48 SP - 497 EP - 500 ER - TY - JOUR TI - Inégalités socio-spatiales de mortalité en France AU - Rican, S. AU - Jougla, E. AU - Salem, G. T2 - Bulletin épidémiologique hebdomadaire CN - 0003 DA - 2003/// PY - 2003 DP - Google Scholar SP - 30 EP - 31 UR - http://sc8.vesinet.inserm.fr/inserm/html/pdf/beh_30_31_p142_145_2003.pdf Y2 - 2012/07/24/08:15:33 ER - TY - CHAP TI - Mortalité prématurée AU - Eb, Mireille AU - Rey, Grégoire T2 - Traité de santé publique T3 - Médecine Science DA - 2016/// PY - 2016 ET - 3 SP - 388 EP - 394 PB - Lavoisier SN - 978-2-257-20679-4 ER - TY - RPRT TI - La santé en France et en Europe : convergences et contrastes AU - Badéyan, Gérard AU - Charpak, Yves AU - Danet, Sandrine AU - Depinoy, Michel AU - Fontaine, Alain AU - Jougla, Eric AU - Sermet, Catherine AU - Viso, Anne-Catherine CN - 0000 CY - Paris DA - 2012/// PY - 2012 PB - Haut Conseil de la Santé Publique ER - TY - RPRT TI - Suicides et autres décès en milieu carcéral en France entre 2000 et 2010 / 2017. Apport des certificats de décès dans la connaissance et le suivi de la mortalité AU - Chan Chee, Christine AU - Moutengou, Elodie CY - Saint-Maurice DA - 2017/// PY - 2017 PB - Santé Publique France SN - 1975-6964 UR - http://invs.santepubliquefrance.fr/Publications-et-outils/Rapports-et-syntheses/Maladies-chroniques-et-traumatismes/2017/Suicides-et-autres-deces-en-milieu-carceral-en-France-entre-2000-et-2010 Y2 - 2017/01/13/08:06:19 ER - TY - CHAP TI - La mortalité prématurée AU - Eb, Mireille AU - Jougla, Eric AU - Rey, Gregoire T2 - Traité de prévention T3 - Médecine Science DA - 2016/// PY - 2016 ET - Flamarion ER - TY - BOOK TI - Les inégalités sociales de santé en France et en Grande-Bretagne: analyse et étude comparative AU - Aïach, Pierre DA - 1987/// PY - 1987 DP - Google Scholar PB - Documentation française ST - Les inégalités sociales de santé en France et en Grande-Bretagne ER - TY - RPRT TI - Indicateurs de suivi de l'évolution des inégalités sociales de santé dans les systèmes d'information en santé. AU - Lang, Thierry AU - Cases, Chantal AU - Chauvin, Pierre AU - Jougla, Eric AU - Jusot, Florence AU - Lombrail, Pierre AU - Menvielle, Gwenn CY - Paris DA - 2013///juin PY - 2013 PB - Haut Conseil de la Santé Publique ER - TY - RPRT TI - Indicateurs de mortalité "prématurée" et "évitable" AU - Jougla, Eric CY - Paris DA - 2013///avril PY - 2013 PB - Haut Conseil de la Santé Publique ER - TY - CHAP TI - Les inégalités territoriales de santé. AU - Rican, Stéphane AU - Jougla, Eric AU - Vaillant, Zoé AU - Salem, Gérard T2 - Vers l'égalité des territoires – dynamiques, mesures, politiques CY - Paris DA - 2013/// PY - 2013 ET - La documentation Française SP - 106 EP - 22 PB - Laurent E ER - TY - RPRT TI - Evaluation à mi-parcours du plan cancer 2009-2013. AU - Bar-Hen, A AU - Boué, F AU - Buthion, V AU - Cases, C AU - Jougla, Eric AU - Metzger, MH AU - Sermet, Catherine AU - Tallec, Anne CY - Paris DA - 2012///Juin PY - 2012 PB - Haut Conseil de la Santé Publique ER - TY - RPRT TI - Renouveler une application web en milieu scientifique. Rapport de stage de fin d’étude (maître de stage : G Rey), IUT d’informatique, Paris V Descartes, AU - Guy-Coichard, Flora CY - Le Kremlin-Bicêtre DA - 2012///Juillet PY - 2012 ER - TY - RPRT TI - Etude des causes de mortalité des personnes sans domicile en France sur la période 2008-2009. Mémoire de Master 2 (direction : G Rey), Recherche en Santé Publique, Parcours épidémiologie. AU - Vuillermoz, Cécile CY - Le Kremlin-Bicêtre DA - 2012///juin PY - 2012 ER - TY - RPRT TI - Pour une meilleure utilisation des bases de données administratives et médico-administratives nationales pour la santé publique et la recherche. AU - Goldberg, Marcel AU - Berr, C AU - Dabis, François AU - Hugot, JP AU - Jougla, Eric AU - Sermet, Catherine AU - Danet, Sandrine AU - Grémy, Isabelle AU - Charpak, Yves AU - Desenclos, Jean-Claude AU - Poubelle, Vincent AU - Ricordeau, Philippe AU - Trugeon, Alain AU - Weill, Alain AU - Badéyan, Gérard CY - Paris DA - 2012/03// PY - 2012 PB - Haut Conseil de la Santé Publique ER - TY - RPRT TI - Quality and comparability improvement of European causes of death statistics AU - Jougla, Eric AU - Rossollin, Florence AU - Niyonsenga, Antoine AU - Chappert, Jean-Louis AU - Johansson, Lars Age AU - Pavillon, Gérard DA - 2001/07// PY - 2001 ER - TY - RPRT TI - Atlas de la mortalité dans l'union européenne. Données 1994-1996 AU - Jougla, Eric AU - Salem, Gérard AU - Gancel, Sophie AU - Michel, Vincent AU - Kürzinger, Marie-Laure AU - Pavillon, Gérard AU - Rican, Stéphane AU - Hamzaoui, Nassima DA - 2002/// PY - 2002 PB - Eurostat ER - TY - SLIDE TI - How do European researchers access health data in France? T2 - PHRIMA Workshop A2 - Rey, Grégoire A2 - Normand, Geoffrey A2 - Lesaulnier, Frédérique A2 - Chêne, Geneviève CY - Paris DA - 2017/10/01/ PY - 2017 ER - TY - SLIDE TI - CLEF eHEALTH 2016 : Extraction des causes de décès à partir du texte issu des certificats électroniques de décès T2 - Séminaire scientifique du CESP A2 - Robert, Aude CY - Villejuif DA - 2016/04/10/ PY - 2016 ER - TY - SLIDE TI - Survival analysis with multiple causes of death: extending the competing risks model T2 - International Workshop on multicause Network A2 - Moreno-Betancur, Margarita A2 - Sadaoui, Hamza A2 - Piffaretti, Clara A2 - Rey, Grégoire CY - Prague, Czech Republic DA - 2016/06/02/ PY - 2016 ER - TY - SLIDE TI - Utilisation et appariement des bases de données médico-administratives à des fins de recherche et de santé publique T2 - Les Printemps de la FM A2 - Rey, Grégoire CY - Beyrouth, Liban DA - 2017//03/juin PY - 2017 ER - TY - SLIDE TI - Le SNDS et le projet d’Infrastructure de services relatifs aux données de santé pour la recherche T2 - Séminaire scientifique iPLESP A2 - Rey, Grégoire A2 - Normand, Geoffrey CY - Paris DA - 2016//15/décembre PY - 2016 ER - TY - SLIDE TI - Le SNDS et le projet d’Infrastructure de services relatifs aux données de santé pour la recherche T2 - Séminaire scientifique du CESP A2 - Normand, Geoffrey CY - Villejuif DA - 2016/11/16/ PY - 2016 ER - TY - SLIDE TI - Construction d'indicateurs de mortalité post-hospitalière à partir d'un appariement des données des causes de décès et du SNIIRAM T2 - Séminaire scientifique IGR A2 - Rey, Grégoire A2 - Bounebache, Karim A2 - Lamarche-Vadel, Agathe CY - Villejuif DA - 2016/11/07/ PY - 2016 ER - TY - SLIDE TI - Système National des Données de Santé : présentation, services proposés à la recherche et perspectives de développements méthodologiques T2 - Journées G. D. R. Statistique et Santé Société Française de Biométrie A2 - Rey, Grégoire CY - Lyon DA - 2016//28/juin PY - 2016 ER - TY - SLIDE TI - Le nouveau cadre législatif et les dispositifs pour l'exploitation des données de santé par la recherche T2 - Séminaire METIS EHESP A2 - Rey, Grégoire CY - Rennes DA - 2016//16/juin PY - 2016 ER - TY - SLIDE TI - Impact de la loi de modernisation de notre système de soin : Causes de décès, Services pour la recherche T2 - CNIS – Services publics et services au public A2 - Rey, Grégoire CY - Paris DA - 2016///1er juin PY - 2016 ER - TY - SLIDE TI - Causes médicales de décès : Mode de production - Injection dans le SNDS, Analyse T2 - Atelier méthodologique Cnamts A2 - Rey, Grégoire CY - Paris DA - 2016//24/juin PY - 2016 ER - TY - SLIDE TI - Analyse de la mortalité post-hospitalière à partir des données qui composeront le SNDS : Infrastructure sur les données de santé pour la recherche T2 - Séminaire méthodolique ANRS A2 - Rey, Grégoire CY - Paris DA - 2016//06/décembre PY - 2016 ER - TY - SLIDE TI - SNDS et CEPIDS : Infrastructure de services relatifs aux données de santé pour la recherche T2 - Le SNIIRAM pour la recherche en santé A2 - Rey, Grégoire CY - Rennes DA - 2017//26/juin PY - 2017 ER - TY - SLIDE TI - Infrastructure sur les données de santé pour la recherche T2 - IXème journée annuelle des CIC A2 - Rey, Grégoire A2 - Lesaulnier, Frédérique A2 - Bounebache, Karim A2 - Dumont, Gwenaël A2 - Archer, Vincent A2 - Normand, Geoffrey AB - Contexte L’article 193 de la Loi de modernisation de notre système de santé prévoit de regrouper dans un Système National des Données de Santé (SNDS) les grandes bases de données médico-administratives (BDMA) : SNIIRAM, PMSI, et causes de décès dans un premier temps. L’accès en sera ainsi facilité pour des finalités d’intérêt public. Ces données couvriraient la quasi-totalité de la population française. Une enquête de besoins pour la recherche a été réalisée en 2016 auprès de 640 chercheurs ou équipes. Elle a permis de mettre en évidence le fort intérêt de cette communauté pour les données du SNDS et l’étendue des besoins de conseil et support pour l’exploitation de ces données. En effet, le circuit d'autorisation pour l’accès reste complexe, les contraintes de sécurité et de confidentialité sont renforcées, le savoir-faire et l’expertise techniques sont encore insuffisamment répandus. Dans ce contexte, l'Inserm est à l'initiative de la création d'une infrastructure visant à proposer des services à la communauté des chercheurs en santé, pour le compte des alliances Aviesan et Athena. Services proposés Deux grands types de services seraient ainsi proposés par l'infrastructure : - des services de conseils sur i) les aspects réglementaires et juridiques des demandes (élaboration d'outils facilitant le traitement, de méthodologies de référence en concertation avec les instances réglementaires, aide à la préparation des dossiers), ii) les aspects scientifiques et techniques relevant des méthodes d'exploitation des données et des prérequis de système d'information (renforcement de la recherche sur les algorithmes d'identification de pathologie, techniques et outils d'appariement à d'autres bases de données) - des services de mise en œuvre des extractions en partenariat avec la Cnamts, des appariements (si nécessaire) avec les cohortes et registres, incluant une traçabilité des accès et des traitements et des possibilités de Calcul Haute Performance. Ces différents services pourront être proposés aux équipes de chercheurs de façon adaptative en fonction du besoin. Ils s'appuieront sur des consultations régulières sur le besoin des chercheurs. Mise en œuvre La mise en place d'un portail de dépôt des demandes, des outils informatiques nécessaires, d'une équipe en charge d'assurer un traitement rapide et mutualisé de celles-ci, et de partenariats d'échanges avec des experts du domaine, est en cours. Une animation scientifique autour des grandes thématiques de traitement des données du SNDS se construit par ailleurs avec la communauté de recherche en santé pour assurer la meilleure pertinence des services de l'infrastructure et de l'exploitation des données. L'infrastructure ouvrira graduellement ses services à l'ensemble de la communauté des chercheurs à partir de février 2017. CY - Rouen DA - 2017//20/avril PY - 2017 ER - TY - SLIDE TI - Infrastructure sur les données de santé pour la recherche T2 - Congrès ADELF-EMOIS A2 - Rey, Grégoire A2 - Lesaulnier, Frédérique A2 - Bounebache, Karim A2 - Dumont, Gwenaël A2 - Archer, Vincent A2 - Normand, Geoffrey AB - Contexte L’article 193 de la Loi de modernisation de notre système de santé prévoit de regrouper dans un Système National des Données de Santé (SNDS) les grandes bases de données médico-administratives (BDMA) : SNIIRAM, PMSI, et causes de décès dans un premier temps. L’accès en sera ainsi facilité pour des finalités d’intérêt public. Ces données couvriraient la quasi-totalité de la population française. Une enquête de besoins pour la recherche a été réalisée en 2016 auprès de 640 chercheurs ou équipes. Elle a permis de mettre en évidence le fort intérêt de cette communauté pour les données du SNDS et l’étendue des besoins de conseil et support pour l’exploitation de ces données. En effet, le circuit d'autorisation pour l’accès reste complexe, les contraintes de sécurité et de confidentialité sont renforcées, le savoir-faire et l’expertise techniques sont encore insuffisamment répandus. Dans ce contexte, l'Inserm est à l'initiative de la création d'une infrastructure visant à proposer des services à la communauté des chercheurs en santé, pour le compte des alliances Aviesan et Athena. Services proposés Deux grands types de services seraient ainsi proposés par l'infrastructure : - des services de conseils sur i) les aspects réglementaires et juridiques des demandes (élaboration d'outils facilitant le traitement, de méthodologies de référence en concertation avec les instances réglementaires, aide à la préparation des dossiers), ii) les aspects scientifiques et techniques relevant des méthodes d'exploitation des données et des prérequis de système d'information (renforcement de la recherche sur les algorithmes d'identification de pathologie, techniques et outils d'appariement à d'autres bases de données) - des services de mise en œuvre des extractions en partenariat avec la Cnamts, des appariements (si nécessaire) avec les cohortes et registres, incluant une traçabilité des accès et des traitements et des possibilités de Calcul Haute Performance. Ces différents services pourront être proposés aux équipes de chercheurs de façon adaptative en fonction du besoin. Ils s'appuieront sur des consultations régulières sur le besoin des chercheurs. Mise en œuvre La mise en place d'un portail de dépôt des demandes, des outils informatiques nécessaires, d'une équipe en charge d'assurer un traitement rapide et mutualisé de celles-ci, et de partenariats d'échanges avec des experts du domaine, est en cours. Une animation scientifique autour des grandes thématiques de traitement des données du SNDS se construit par ailleurs avec la communauté de recherche en santé pour assurer la meilleure pertinence des services de l'infrastructure et de l'exploitation des données. L'infrastructure ouvrira graduellement ses services à l'ensemble de la communauté des chercheurs à partir de février 2017. CY - Nancy DA - 2017/03/24/ PY - 2017 ER - TY - SLIDE TI - SNDS : Causes de décès et infrastructure de services pour la recherche T2 - Matinée du Collège des économistes de la santé A2 - Rey, Grégoire A2 - Lesaulnier, Frédérique A2 - Bounebache, Karim A2 - Dumont, Gwenaël A2 - Archer, Vincent A2 - Normand, Geoffrey CY - Paris DA - 2017/03/23/ PY - 2017 ER - TY - SLIDE TI - The measure of socioeconomic gradients in years lost and its decomposition by cause of death T2 - Population-based Time-to-event Analyses International Conference A2 - Latouche, Aurélien A2 - Rey, Grégoire A2 - Moreno-Betancur, Margarita CY - London DA - 2016/08/31/ PY - 2016 ER - TY - SLIDE TI - Automatic coding of death certificates at CLEF eHealth 2016 T2 - WHO - Family of international classifications network annual meeting A2 - Robert, Aude A2 - Névéol, Aurélie A2 - Grouin, Cyril A2 - Lavergne, Thomas A2 - Rey, Grégoire A2 - Rondet, Claire A2 - Zweigenbaum, Pierre AB - We report on a large scale classification task in French death certificates of the 2016 CLEF eHealth evaluation lab. It consisted of extracting causes of death as coded in the International Classification of Diseases, tenth revision (ICD10). Participant systems were evaluated against 27,850 death certificates using Precision, Recall and F-measure. Five teams participated. The highest performance was 0.848 F-measure. CY - Tokyo, Japan DA - 2016/10/08/12 PY - 2016 ER - TY - SLIDE TI - The statistical modeling of mortality with multiple causes of death T2 - WHO - Family of international classifications network annual meeting A2 - Moreno-Betancur, Margarita A2 - Piffaretti, Clara A2 - Sadaoui, Hamza A2 - Lamarche-Vadel, Agathe A2 - Rey, Grégoire AB - Most mortality indicators and epidemiologic studies assume that death is caused by the “underlying cause of death”, and other diseases mentioned on the death certificate are most often ignored. Not only are these data discarded, but the assumption that death is caused by exactly one disease is questionable. We proposed a statistical model to reflect that death may be caused by several diseases acting together, by using all the data contained in the death certificate. The model can be used to derive burden of disease indicators and study the effect of exposures on disease-related mortality CY - Tokyo, Japan DA - 2016/10/08/12 PY - 2016 ER - TY - SLIDE TI - Analyse multiniveaux d'un évènement rare de santé. Etude de faisabilité, application à la mortalité par cause en population générale A2 - Ghosn, Walid A2 - Rican, Stéphane A2 - Rey, Grégoire CY - Séminaire INED-SMS "Analyse multiniveau" DA - 2016/05/23/ PY - 2016 ER - TY - SLIDE TI - Analyse multiniveaux d'un évènement rare de santé. Etude de faisabilité, application à la mortalité par cause en population générale A2 - Ghosn, Walid A2 - Rican, Stéphane A2 - Rey, Grégoire CY - Groupe utilisateurs EDP DA - 2016/05/19/ PY - 2016 ER - TY - SLIDE TI - Perspectives générales SurSaUD ® Zoom sur SAMU et certification électronique des décès : Zoom sur la certification électronique des décès T2 - 1ères Journées scientifiques SurSaUD® / ASTER A2 - Rey, Grégoire CY - Saint-Maurice DA - 2014/11/21/ PY - 2014 ER - TY - SLIDE TI - How to better visualise the distribution of expected annual deaths in a "standard" French GP surgery? Rebuilding the three main illness trajectories through a modified Delphi study. T2 - 9th World Research Congress of the European Association for Palliative Care A2 - Moine, Sébastien A2 - Murray, Scott A2 - Gomez Batiste, Xavier A2 - Van den Eyden, Bart A2 - Engels, Yvonne A2 - Desesquelles, Aline A2 - Rey, Grégoire A2 - Gignon, Maxime A2 - Oishi, Ai A2 - Boyd, Kirsty A2 - Murtagh, Fliss A2 - Mitchell, Geoff CY - Dublin DA - 2016/06/10/ PY - 2016 ER - TY - SLIDE TI - Exploitation des bases de donnés médico-administratives A2 - Rey, Grégoire CY - Comité d'Interface Inserm - Médecine générale DA - 2015/09/10/ PY - 2015 ER - TY - SLIDE TI - Quality of care assessment based on mortality data A2 - Rey, Grégoire CY - International Congress, La Manga Del Mar Menor DA - 2015/06/09/ PY - 2015 ER - TY - SLIDE TI - Evaluation de la qualité des soins à l'aide de données de mortalité A2 - Rey, Grégoire CY - Lausanne DA - 2015//30/juin PY - 2015 ER - TY - CONF TI - Mise en place d’un système d’information et de codage automatisé des causes de décès dans un contexte Africain AU - Golo Barro, Seydou AU - Dufour, Jean-Charles AU - Malo, Sadouanouan AU - Rey, Grégoire AU - Piarroux, Martine AU - Staccini, Pascal T2 - Journées Francophones d'Informatique Médicale 2016 AB - Contexte. L’OMS a standardisé les procédures pour l’enregistrement et le codage des causes de décès. Cependant, leur application manuelle conduit à des erreurs et à des divergences d’interprétations. Ceci a pour conséquence de diminuer la qualité et la com-parabilité de ces statistiques de mortalité. La plupart des pays développés utilisent un lo-giciel de codage automatisé des causes de décès, contrairement à la majorité des pays en développement où les décès ne sont pas enregistrés selon les normes de l’OMS. Objectif. Le but de ce travail était d’étudier un modèle d’enregistrement et codage automatisé des causes de décès dans un contexte Africain. Méthode.Nous avons utilisé une « re-cherche-interventionnelle » combinée à une démarche projet et à une approche épidé-miologique. Résultats. Les résultats suivants ont été obtenus : conception d’un système global d’information sur les décès « SICD » et implémentation d’un modèle pilote au CHU de Bobo Dioulasso après formation des acteurs. Conclusion. Le SICD fonctionne depuis le 1er janvier 2014 et une première évaluation s’est avérée satisfaisante. La mise en place d’un comité de suivi et d’un plan annuel de formation, l’assistance technique du CepiDc / Inserm (France) sont des éléments d’appropriation, de pérennisation et d’espoir. C1 - Genève DA - 2016//27/29 juin PY - 2016 ER - TY - CONF TI - The French automated coding system Styx AU - Pavillon, Gérard AU - Jougla, Eric T2 - International Collaborative Effort on Automating Mortality Statistics C1 - Bethesda, Maryland, USA C3 - Proceedings of the International Collaborative Effort on Automating Mortality Statistics DA - 2001/// PY - 2001 VL - 2 SP - 50 EP - 51 ER - TY - SLIDE TI - L'utilisation des données DADS chainées aux causes de décès pour étudier l'association entre trajectoires socioprofessionnelles et mortalité par cause A2 - Karimi, Maryam CY - les Rencontres de Statistique Appliquée, Paris DA - 2015/11/24/ PY - 2015 ER - TY - SLIDE TI - Joint modeling of socioprofessional trajectory and cause-specific mortality A2 - Karimi, Maryam A2 - Rey, Grégoire A2 - Latouche, Aurélien CY - ISCB, Utrecht DA - 2015/08/23/27 PY - 2015 M3 - Poster ER - TY - SLIDE TI - Revision of the French Dictionary for ICD10 cause of death coding A2 - Boulat, Thierry A2 - Robert, Aude A2 - Vazifeh, Layla A2 - Rey, Grégoire A2 - Lamarche-Vadel, Agathe CY - OMS conference, Manchester DA - 2015/10/17/23 PY - 2015 M3 - Poster ER - TY - SLIDE TI - La mortalité en chiffres A2 - Rey, Grégoire CY - Les Entretiens Médicaux d'Enghien DA - 2015/10/03/ PY - 2015 ER - TY - SLIDE TI - Impact of unemployment rate variations and the economic crisis on suicide mortality in Western European countries (2000-2010) A2 - Laanani, Moussa A2 - Rey, Grégoire CY - 8th European Public Health Conference, Milan DA - 2015/10/17/ PY - 2015 ER - TY - SLIDE TI - Analyse de la mortalité avec pondération des causes multiples de décès A2 - Rey, Grégoire CY - Séminaire INED, Paris DA - 2015//05/fév PY - 2015 ER - TY - SLIDE TI - Point sur l'infrastructure IEPI et évolution A2 - Rey, Grégoire CY - Club Cohortes, Paris DA - 2015//21/avril PY - 2015 ER - TY - SLIDE TI - Mesures des inégalités socio-spatiales de santé T2 - Séminaire inégalités sociales de santé A2 - Rey, Grégoire CY - DREES, Paris DA - 2015/03/12/ PY - 2015 ER - TY - SLIDE TI - Survival analysis with multiple causes of death: Reconsidering the competing risks model A2 - Moreno-Betancur, Margarita A2 - Sadaoui, Hamza A2 - Piffaretti, Clara A2 - Rey, Grégoire CY - ISCB, Utrecht DA - 2015/08/27/ PY - 2015 ER - TY - SLIDE TI - Certificat de décès : les vérités bonnes à dire T2 - Congrès de l'ordre des médecin A2 - Rey, Grégoire CY - CNIT, La Défense DA - 2014/10/17/ PY - 2014 ER - TY - SLIDE TI - Traitement des données de mortalité en France T2 - Addiction à un produit : combien de morts A2 - Eb, Mireille CY - Ateliers de la pharmacodépendance et addictovigilance, Biarritz DA - 2014/10/28/ PY - 2014 ER - TY - SLIDE TI - AMPHI : Analyse de la mortalité post-hospitalière, calcul d'indicateurs par établissement A2 - Lamarche-Vadel, Agathe A2 - Ngantcha, Marcus A2 - Rey, Grégoire CY - Séminaire scientifique du Centre d’Epidémiologie Clinique DA - 2013//18/décembre PY - 2013 ER - TY - SLIDE TI - Les facteurs sociaux et territoriaux associés à la variation de la mortalité par suicide en France. A2 - Rey, Grégoire A2 - Laanani, Moussa A2 - Jougla, Eric CY - Congrès français de psychiatrie, Nice DA - 2013/11/27/30 PY - 2013 ER - TY - SLIDE TI - Données épidémiologiques sur la mortalité par suicide en France A2 - Rey, Grégoire A2 - Laanani, Moussa CY - Observatoire National du Suicide DA - 2014//01/avril PY - 2014 ER - TY - SLIDE TI - Du certificat de décès à la donnée : différentes étapes du circuit. Programme de travail respectif A2 - Rey, Grégoire CY - Séminaire scientifique de l'InVS, Saint-Maurice DA - 2014//12/mai PY - 2014 ER - TY - SLIDE TI - Indice de désavantage social A2 - Rey, Grégoire A2 - Blotière, Pierre-Olivier A2 - Mocellin, Jérôme A2 - Jougla, Eric A2 - Rican, Stéphane CY - Journées scientifiques de l’Assurance maladie,Paris DA - 2012/10/09/10 PY - 2012 ER - TY - SLIDE TI - Données épidémiologiques sur la mortalité par suicide en France - effet de la crise économique de 2008 A2 - Rey, Grégoire CY - Lancement de l’Observatoire National du Suicide, Ministère de la Santé, Paris DA - 2013/09/10/ PY - 2013 ER - TY - SLIDE TI - Les données de mortalité actuellement disponibles. A2 - Laanani, Moussa A2 - Jougla, Eric A2 - Rey, Grégoire CY - Journées du groupement d'études et de prévention du suicide, "Prévenir le suicide dans le monde du travail". DA - 2013/10/24/25 PY - 2013 ER - TY - SLIDE TI - Désavantage social et disparités spatiales de mortalité en France depuis 1990. A2 - Rey, Grégoire CY - Colloque international « Dynamiques urbaines et enjeux sanitaires – concepts, méthodes et interventions », Nanterre DA - 2013/09/11/13 PY - 2013 ER - TY - SLIDE TI - Evolutions de la place des déterminants contextuels et des déterminants individuels dans les inégalités de mortalité en France A2 - Ghosn, Walid CY - Colloque international « Dynamiques urbaines et enjeux sanitaires – concepts, méthodes et interventions », Nanterre DA - 2013/09/11/13 PY - 2013 ER - TY - SLIDE TI - L'association temporelle entre chômage, crise économique et suicide en Europe et en France. A2 - Laanani, Moussa A2 - Jougla, Eric A2 - Rey, Grégoire CY - Congrès annuel des internes de santé publique, Paris DA - 2013//04/juin PY - 2013 ER - TY - SLIDE TI - Variation de la mortalité par suicide selon le taux de chômage de 2000 à 2010 , France A2 - Laanani, Moussa A2 - Jougla, Eric A2 - Ghosn, Walid A2 - Rey, Grégoire CY - SFSP-Adelf, Bordeaux DA - 2013/10/17/19 PY - 2013 ER - TY - SLIDE TI - Estimation du nombre de décès de personnes sans domicile, 2008-2010 A2 - Vuillermoz, Cécile A2 - Aouba, Albertine A2 - Grout, Lise A2 - Tassin, Fanny A2 - Jougla, Eric A2 - Rey, Grégoire CY - Congrès SFSP, ADELF, Bordeaux DA - 2013/10/17/19 PY - 2013 ER - TY - SLIDE TI - A French experience since 2005 A2 - Bonnélie, Isabelle CY - Eurostat workshop on electronic death certification, Eurostat, Luxembourg DA - 2013/03/06/ PY - 2013 ER - TY - SLIDE TI - Causes de décès et mortalité évitable. A2 - Jougla, Eric CY - Journée scientifique de l'AMCAP, Paris DA - 2013//12/avril PY - 2013 ER - TY - SLIDE TI - Mortality data - closing conference on methods and perspectives. A2 - Jougla, Eric CY - BAPH workshop on mortality data, Brussels DA - 2013/03/01/ PY - 2013 ER - TY - SLIDE TI - Les causes médicales de décès - mode de production et utilisation pour la surveillance épidémiologique A2 - Rey, Grégoire CY - Cours d’introduction aux métiers de l’InVS, Saint-Maurice DA - 2013/01/28/ PY - 2013 ER - TY - SLIDE TI - Indice de désavantage social A2 - Rey, Grégoire CY - Séminaire scientifique de l'InVS, Saint-Maurice DA - 2013/01/31/ PY - 2013 ER - TY - SLIDE TI - Qualité des certificats de décès français : comparaison des certificats électroniques aux certificats papiers A2 - Lefeuvre, Delphine A2 - Pavillon, Gérard A2 - Lamarche-Vadel, Agathe A2 - Fouillet, Anne A2 - Aouba, Albertine A2 - Jougla, Eric A2 - Rey, Grégoire CY - Congrès Emois, Nancy DA - 2013/03/21/22 PY - 2013 ER - TY - SLIDE TI - The state of mortality by suicide in France. A2 - Rey, Grégoire A2 - Laanani, Moussa A2 - Jougla, Eric CY - Eurostat Technical meeting, Luxembourg. DA - 2013/03/05/ PY - 2013 ER - TY - SLIDE TI - Appariement des données SNIIR-AM-PMSI et causes de décès. A2 - Lamarche-Vadel, Agathe A2 - Jougla, Eric A2 - Rey, Grégoire CY - Séminaire sur les systèmes d'information pour la santé publique, la surveillance et la recherche, Paris DA - 2013//12/février PY - 2013 ER - TY - SLIDE TI - La mortalité évitable : un concept pertinent ? A2 - Rey, Grégoire CY - Congrès national des Observatoires Régionaux de la Santé, Bordeaux DA - 2013//04/5 avril PY - 2013 ER - TY - SLIDE TI - Alcohol use, cancer deaths, and years of potential life lost in the United States. A2 - Nelson, David E A2 - Naimi, Timothy S A2 - Jarman, Dwayne W A2 - Rehm, Jürgen A2 - Rey, Grégoire A2 - Shield, Kevin D A2 - Miller, Paige CY - American Public Health Association 140th annual meeting, Prevention and wellness across the life span, San Francisco DA - 2012/10/27/31 PY - 2012 ER - TY - SLIDE TI - Indicateurs de désavantages locaux en lien avec la santé. A2 - Rican, Stéphane CY - Rencontres annuelles de l'INCa, Inégalités face aux cancers, Paris DA - 2012//04/décembre PY - 2012 ER - TY - SLIDE TI - Déclarer les décès en ligne avec l'application CertDc. A2 - Bonnélie, Isabelle CY - Journée des référents dun système de surveillance syndromique SurSaUD, InVS, Saint-Maurice DA - 2012//11/décembre PY - 2012 ER - TY - SLIDE TI - Accès des registres aux certificats de décès. A2 - Rey, Grégoire CY - Colloque registre et politique de santé publique, Paris DA - 2012//06/7 décembre PY - 2012 ER - TY - SLIDE TI - Stability analysis ICD 10 - ICD11 A2 - Pavillon, Gérard A2 - Jakob, Robert A2 - Notzon, F Sam CY - Mortality TAG - RSG-SEG Meeting, Las Vegas DA - 2012/03/14/18 PY - 2012 ER - TY - SLIDE TI - Need for comparability between MMDS and Iris. A2 - Johansson, Lars Age A2 - Pavillon, Gérard A2 - Weber, Stefanie CY - ICE Meeting, Washington DA - 2012/03/26/27 PY - 2012 ER - TY - SLIDE TI - Iris – International automated coding system for causes of death. A2 - Pavillon, Gérard A2 - Johansson, Lars Age A2 - Weber, Stefanie CY - Informatics Terminology Committee, WHO FIC Annual meeting, Brasilia DA - 2012/10// PY - 2012 ER - TY - SLIDE TI - Appariement du PMSI-MCO ⬚aux Causes médicales de décès ⬚via le SNIIRAM (2008-2009), France A2 - Lamarche-Vadel, Agathe A2 - Rey, Grégoire CY - Saint-Maurice DA - 2012//04/décembre PY - 2012 ER - TY - SLIDE TI - Urban networks and spatiotemporal dynamics of mortality in France. A2 - Rican, Stéphane A2 - Ghosn, Walid A2 - Rey, Grégoire A2 - Jougla, Eric A2 - Salem, Gérard CY - Colloque Health & Space, Marseille DA - 2012/09// PY - 2012 ER - TY - SLIDE TI - Données de mortalité en France. A2 - Eb, Mireille A2 - Rey, Grégoire CY - Groupe des Data Managers Académiques, Centre François Baclesse, Caen DA - 2012//12/13 juin PY - 2012 ER - TY - SLIDE TI - Mortality and automated coding systems. A2 - Jougla, Eric CY - Iris Institute Opening, DIMDI, Cologne DA - 2012/09/12/ PY - 2012 ER - TY - SLIDE TI - Iris - an international coding system for causes of death A2 - Pavillon, Gérard A2 - Johansson, Lars Age CY - International workshop on multiple cause-of-death, Ined, Paris DA - 2012/11/22/23 PY - 2012 ER - TY - SLIDE TI - Evolution of the causes of death among HIV-infected patients between 2000 and 2010: results of the French national survey "ANRS EN20 mortalité 2010" A2 - Morlat, Philippe A2 - Roussillon, Caroline A2 - Hénard, S A2 - Rosenthal, Eric A2 - Oksenhendler, E A2 - Aouba, Albertine A2 - Marchou, B A2 - May, Thierry A2 - Salmon, Dominique A2 - Chêne, Geneviève CY - CROI DA - 2012/03/09/ PY - 2012 M3 - Poster ER - TY - SLIDE TI - Différentiels spatiaux de mortalité et degré de connectivité entre 1990 et 1999: étude des échanges migratoires entre aires urbaines. A2 - Ghosn, Walid A2 - Rican, Stéphane A2 - Rey, Grégoire CY - Colloque Thématique de l'ADELF  "Épidémiologie Sociale et inégalités de santé", Toulouse DA - 2012//15/16 mai PY - 2012 ER - TY - SLIDE TI - Appariement de la base de donnée PMSI-MCO à celle des causes médicales de décès via le SNIIR-AM A2 - Lamarche-Vadel, Agathe A2 - Rey, Grégoire CY - Séminaire "Appariements sécurisés", Ined, Paris DA - 2012/01/19/ PY - 2012 ER - TY - SLIDE TI - Comparaison du diagnostic principal de la dernière hospitalisation et de la cause initiale du certificat de décès en 2008-2009 A2 - Lamarche-Vadel, Agathe A2 - Pavillon, Gérard A2 - Aouaba, Albertine A2 - Meyer, Laurence A2 - Jougla, Eric A2 - Rey, Grégoire CY - Congrès Adelf-Emois, Dijon DA - 2012/03/12/13 PY - 2012 ER - TY - SLIDE TI - Appariement du PMSI-MCO aux causes médicales de décès via le Sniiram (2008-2009) A2 - Lamarche-Vadel, Agathe A2 - Weill, Alain A2 - Blotière, Pierre-Olivier A2 - Moty-Monnereau, Céline A2 - Jougla, Eric A2 - Rey, Grégoire CY - Congrès Adelf-Emois, Dijon DA - 2012/03/12/13 PY - 2012 ER - TY - CONF TI - Mise en place d’un système d’information et de codage automatisé des causes de décès dans un contexte Africain AU - Golo Barro, Seydou AU - Barro, Seydou Golo AU - Dufour, Jean-Charles AU - Malo, Sadouanouan AU - Rey, Grégoire AU - Piarroux, Martine AU - Staccini, Pascal C1 - Genève DA - 2016/// PY - 2016 ER - TY - JOUR TI - Mortality among homeless people in France, 2008-10 AU - Vuillermoz, Cécile AU - Aouba, Albertine AU - Grout, Lise AU - Vandentorren, Stéphanie AU - Tassin, Fanny AU - Moreno-Betancur, Margarita AU - Jougla, Éric AU - Rey, Grégoire T2 - European Journal of Public Health AB - BACKGROUND: Studies in various countries have shown that homeless people have high mortality levels. The aims of this study concerning the French population were to investigate mortality among the homeless and to study their causes of death in comparison to those of the general population. METHODS: A representative sample of 1145 homeless deaths registered by an association was matched to the national database of medical causes of death using common descriptive variables. Log-binomial regression was used to compare mortality among the homeless to that of the general population. Multiple imputation was used to manage missing causes of deaths. RESULTS: Out of the 1145 registered homeless deaths, 693 were matched to the causes of death database. Homeless deaths were young (average age: 49). Overall, homeless deaths were slightly more frequent during winter. Among all deaths, the probability of being homeless was higher when dying from hypothermia (RR = 6.4), alcohol-related deaths (RR = 1.7), mental disorders, diseases of the digestive and circulatory systems, and undetermined causes (RR from 1.5 to 3.7). CONCLUSION: The homeless died at 49 years old on average compared with 77 in the general population in 2008-10. The health of homeless people should be considered not only in winter periods or in terms of alcohol- or cold-related conditions. This study also highlights the need for more precise data to estimate the mortality risks of the homeless in France. DA - 2016/06/21/ PY - 2016 DO - 10.1093/eurpub/ckw083 DP - PubMed J2 - Eur J Public Health LA - ENG SN - 1464-360X ER - TY - CHAP TI - Mesures des inégalités socio-spatiales de santé AU - Rey, Grégoire T2 - Les inégalités sociales de santé - Actes du séminaire de recherche de la DREES 2015-2016 AB - Ce texte vise à faire le point d'une façon générale sur la mesure des inégalités socio-spatiales en routine avec des bases de données produites en population générale. Il est question des outils qui permettent de synthétiser la mesure des inégalités socio-spatiales de santé avec les bases de données existantes en France. Ce type de mesure est utilisé dans un objectif descriptif, mais nécessite néanmoins de satisfaire à des contraintes de précision et de comparabilité dans le temps et dans l’espace, notamment à l’international. Pour chacune des approches individuelles et spatiales, les données disponibles, les méthodes de mesure existantes et les précautions méthodologiques ou d’interprétation parfois nécessaires sont décrites. DA - 2017/08/11/ PY - 2017 SP - 70 EP - 80 PB - DREES ER - TY - JOUR TI - Revue Bibliographique des Méthodes de Couplage des Bases de Données : Applications et Perspectives dans le Cas des Données de Santé Publique AU - Bounebache, Saïd Karim AU - Quantin, Catherine AU - Benzenine, Eric AU - Obozinski, Guillaume AU - Rey, Grégoire T2 - Journal de la Societe Française de Statistique, AB - Le couplage des bases de données est un enjeu important en santé publique, particulièrement en cette période de multiplication des bases de données administratives et de cohortes (Loth, 2015). Cette procédure consiste à faire correspondre des informations concernant un individu issues de base de données différentes sans pouvoir utiliser un identifiant unique. En France, dans le cas des données médicales et administratives, le Numéro d’Identification au Répertoire (NIR) est un exemple d’identifiant susceptible d’être utilisé pour servir de clé de couplage. Cependant ce dernier restera, en dépit de la loi du 26 janvier 2016 de modernisation de notre système de santé, difficile d’accès en raison de sa qualité d’identifiant direct commun à de nombreuses bases de données. Nous présentons les méthodes de chaînage susceptibles d’être utilisées par des chercheurs, en nous concentrant sur le modèle génératif de Fellegi et Sunter qui est une approche non supervisée, ainsi que sur quelques méthodes issues de l’apprentissage statistique. Enfin nous présentons rapidement différentes approches pour réaliser une analyse statistique sur des données appariées et comment répercuter l’incertitude de l’appariement dans l’analyse. DA - 2018/// PY - 2018 VL - 159 IS - 3 SP - 79 EP - 123 ER - TY - JOUR TI - Socio-economic factors associated with an increase in fruit and vegetable consumption: a 12-year study in women from the E3N-EPIC study AU - Affret, Aurélie AU - Severi, Gianluca AU - Dow, Courtney AU - Mancini, Francesca Romana AU - Rey, Grégoire AU - Delpierre, Cyrille AU - Clavel-Chapelon, Françoise AU - Boutron-Ruault, Marie-Christine AU - Fagherazzi, Guy T2 - Public Health Nutrition AB - OBJECTIVE: To identify individual and contextual socio-economic factors associated with an increase in fruit and vegetable (F&V) consumption over a 12-year period and evaluate if some socio-economic factors were differentially associated with the change in consumption of some types of F&V. DESIGN: Associations between increased F&V consumption and socio-economic factors were studied with multivariate logistic regression. SETTING: E3N, a French prospective cohort study of 98 995 women. SUBJECTS: E3N participants (n 58 193) with information on diet in 1993 and 2005, and numerous individual and contextual socio-economic factors available. RESULTS: Associations between some individual socio-economic factors and changes in F&V consumption were observed. For instance, women who lived in a large household (>3 children v. no child) had higher probability of increasing their vegetable consumption (OR=1·33; 95 % CI 1·24, 1·42). This association was driven by higher consumption of courgette and raw cucumber. Living with a partner was associated with higher odds of increasing consumption of fruits (OR=1·07; 95 % CI 1·02, 1·13) such as pear, peach and grape. CONCLUSIONS: Certain individual socio-economic factors, but none of the contextual socio-economic factors examined, were associated with an increase in F&V consumption. Factors associated with an increase in total F&V consumption were not necessarily associated with an increase in fruit or vegetable consumption separately, or with an increase in each subtype of fruit or vegetable. Magnitudes of the different associations observed also differed when F&V were considered together, separately or by subtype. Increases in F&V consumption were mostly observed in women with high socio-economic position. To develop effective nutritional interventions and policies that take the socio-economic environment of individuals into account, we recommend future research to further focus on (i) pathways through which population characteristics might influence changes in F&V consumption and (ii) existing interactions between individual and contextual socio-economic factors. DA - 2018//03/ PY - 2018 DO - 10.1017/S1368980017003196 DP - PubMed VL - 21 IS - 4 SP - 740 EP - 755 J2 - Public Health Nutr LA - eng SN - 1475-2727 ST - Socio-economic factors associated with an increase in fruit and vegetable consumption KW - Adult KW - Aged KW - Diet KW - E3N-EPIC cohort KW - Epidemiology KW - Evolution of diet KW - Family KW - Family Characteristics KW - Feeding Behavior KW - Female KW - France KW - Fruit KW - Fruit and vegetable KW - Health Behavior KW - Humans KW - Interpersonal Relations KW - Longitudinal Studies KW - Middle Aged KW - Prospective Studies KW - Social Class KW - Social Environment KW - Socio-economic environment KW - Socioeconomic Factors KW - Vegetables ER - TY - JOUR TI - Ability of ecological deprivation indices to measure social inequalities in a French cohort AU - Temam, Sofia AU - Varraso, Raphaëlle AU - Pornet, Carole AU - Sanchez, Margaux AU - Affret, Aurélie AU - Jacquemin, Bénédicte AU - Clavel-Chapelon, Françoise AU - Rey, Grégoire AU - Rican, Stéphane AU - Le Moual, Nicole T2 - BMC public health AB - BACKGROUND: Despite the increasing interest in place effect to explain health inequalities, there is currently no consensus on which kind of area-based socioeconomic measures researchers should use to assess neighborhood socioeconomic position (SEP). The study aimed to evaluate the reliability of different area-based deprivation indices (DIs) in capturing socioeconomic residential conditions of French elderly women cohort. METHODS: We assessed area-based SEP using 3 DIs: Townsend Index, French European Deprivation Index (FEDI) and French Deprivation index (FDep), among women from E3N (Etude épidémiologique auprès des femmes de la Mutuelle Générale de l'Education Nationale). DIs were derived from the 2009 French census at IRIS level (smallest geographical units in France). Educational level was used to evaluate individual-SEP. To evaluate external validity of the 3 DIs, associations between two well-established socially patterned outcomes among French elderly women (smoking and overweight) and SEP, were compared. Odd ratios were computed with generalized estimating equations to control for clustering effects from participants within the same IRIS. RESULTS: The analysis was performed among 63,888 women (aged 64, 47% ever smokers and 30% overweight). Substantial agreement was observed between the two French DIs (Kappa coefficient = 0.61) and between Townsend and FEDI (0.74) and fair agreement between Townsend and FDep (0.21). As expected among French elderly women, those with lower educational level were significantly less prone to be ever smoker (Low vs. High; OR [95% CI] = 0.43 [0.40-0.46]) and more prone to being overweight (1.89 [1.77-2.01]) than women higher educated. FDep showed expected associations at area-level for both smoking (most deprived vs. least deprived quintile; 0.77 [0.73-0.81]) and overweight (1.52 [1.44-1.62]). For FEDI opposite associations with smoking (1.13 [1.07-1.19]) and expected association with overweight (1.20 [1.13-1.28]) were observed. Townsend showed opposite associations to those expected for both smoking and overweight (1.51 [1.43-1.59]; 0.93 [0.88-0.99], respectively). CONCLUSION: FDep seemed reliable to capture socioeconomic residential conditions of the E3N women, more educated in average than general French population. Results varied strongly according to the DI with unexpected results for some of them, which suggested the importance to test external validity before studying social disparities in health in specific populations. DA - 2017/12/15/ PY - 2017 DO - 10.1186/s12889-017-4967-3 DP - PubMed VL - 17 IS - 1 SP - 956 J2 - BMC Public Health LA - eng SN - 1471-2458 KW - Aged KW - Cohort Studies KW - Deprivation index KW - Female KW - France KW - Health Status Disparities KW - Humans KW - Middle Aged KW - Overweight KW - Reproducibility of Results KW - Residence Characteristics KW - Small-Area Analysis KW - Smoking KW - Social inequalities KW - Socioeconomic Factors KW - Socioeconomic factors ER - TY - JOUR TI - The heart of the matter: years-saved from cardiovascular and cancer deaths in an elite athlete cohort with over a century of follow-up AU - Antero-Jacquemin, Juliana AU - Pohar-Perme, Maja AU - Rey, Grégoire AU - Toussaint, Jean-François AU - Latouche, Aurélien T2 - European Journal of Epidemiology AB - To quantify the years of life saved from cardiovascular (CVD), cancer and overall deaths among elite athletes according to their main type of physiological effort performed in the Olympic Games. All French athletes participating in the Games from 1912 to 2012, with vital status validated and cause of death (if concerned) identified by the national registries were included (n = 2814, 455 died) and classified according to 6 groups of effort: POWER (continuous effort TY - JOUR TI - Risk of hospitalisation and death related to baclofen for alcohol use disorders: Comparison with nalmefene, acamprosate, and naltrexone in a cohort study of 165 334 patients between 2009 and 2015 in France AU - Chaignot, Christophe AU - Zureik, Mahmoud AU - Rey, Grégoire AU - Dray-Spira, Rosemary AU - Coste, Joël AU - Weill, Alain T2 - Pharmacoepidemiology and Drug Safety AB - PURPOSE: Baclofen is widely used off-label for alcohol use disorders (AUD) in France, despite its uncertain efficacy and safety, particularly at high doses. This study was designed to evaluate the safety of this off-label use compared to the main approved drugs for AUD (acamprosate, naltrexone, nalmefene). METHODS: This cohort study from the French Health Insurance claims database included patients, aged 18 to 70 years, with no serious comorbidity (assessed by the Charlson score) initiating baclofen or approved drugs for AUD between 2009 and 2015. The risk of hospitalisation or death associated with baclofen, at variable doses over time (from low doses TY - JOUR TI - Giant-cell arteritis-related mortality in France: A multiple-cause-of-death analysis AU - Chazal, Thibaud AU - Lhote, Raphael AU - Rey, Grégoire AU - Haroche, Julien AU - Eb, Mireille AU - Amoura, Zahir AU - Cohen Aubart, Fleur T2 - Autoimmunity Reviews AB - OBJECTIVES: Giant-cell arteritis (GCA) is a large vessel vasculitis. Data regarding mortality are controversial. We describe the mortality data of the French death certificates for the period of 2005 to 2014. METHODS: Using multiple-cause-of-death (MCOD) analysis, we calculated age-adjusted mortality rates for GCA, examined differences in mortality rates according to age and gender and analyzed the underlying causes of death (UCD). RESULTS: We analyzed 4628 death certificates listing a diagnosis of GCA as UCD or non-underlying cause of death (NUCD). The mean age of death was 86 (±6.8) years. The overall age-standardized mortality rate among GCA patients was 7.2 per million population. Throughout the study period, the mean age of death was significantly increased (r = 0.17, p  1 in GCA-associated mortality compared with the general population mortality was observed for tuberculosis, pneumonia and cardiovascular diseases. CONCLUSION: In this analysis of French death certificates mentioning GCA, we observed a stable standardized mortality rate between 2005 and 2014. The most frequent associated diseases were cardiovascular diseases and infections. DA - 2018/12// PY - 2018 DO - 10.1016/j.autrev.2018.06.012 DP - PubMed VL - 17 IS - 12 SP - 1219 EP - 1224 J2 - Autoimmun Rev LA - eng SN - 1873-0183 ST - Giant-cell arteritis-related mortality in France KW - Cardiovascular Diseases KW - Cause of Death KW - Communicable Diseases KW - Death Certificates KW - Epidemiology. KW - France KW - Giant Cell Arteritis KW - Giant—cell arteritis KW - Humans KW - Mortality KW - Neoplasms KW - Neurodegenerative Diseases KW - Prognosis KW - Survival Rate ER - TY - JOUR TI - Mortality causes and trends associated with giant cell arteritis: analysis of the French national death certificate database (1980-2011) AU - Aouba, Achille AU - Gonzalez Chiappe, Solange AU - Eb, Mireille AU - Delmas, Claire AU - de Boysson, Hubert AU - Bienvenu, Boris AU - Rey, Grégoire AU - Mahr, Alfred T2 - Rheumatology (Oxford, England) AB - Objectives: Comprehensive analyses of cause-specific death patterns in GCA are sparse. We studied the patterns and time trends in GCA-related mortality using a large death certificate database. Methods: We obtained multiple-cause-of-death data from the French national death certificate database for 1980-2011. GCA-associated deaths were defined as decedents ⩾55 years old with GCA listed as an underlying or non-underlying cause of death. Time trends of death rates were analysed and the mean age at death with GCA and in the general population ⩾55 years old were calculated. Standardized mortality odds ratios (SMORs) were calculated for 17 selected causes of death (based on 2000-11 data). Results: The analyses pertained to approximately 15 000 death certificates listing GCA (including approximately 6300 for 2000-11). Annual standardized death rates for GCA increased to a peak in 1997 and then decreased (Spearman's correlation test, both P < 0.0001). Mean age at death was higher for GCA than for general population decedents (Student's t-test, P < 0.0001). GCA deaths were frequently or strongly associated with aortic aneurysm and dissection (1.85% of death certificates, SMOR: 3.09, 95% CI: 2.48, 3.82), hypertensive disease (20.78%, SMOR: 2.22, 95% CI: 1.97, 2.50), diabetes mellitus (11.27%, SMOR: 1.96, 95% CI: 1.72, 2.23), certain infectious and parasitic diseases (12.12%, SMOR: 1.76, 95% CI: 1.55, 2.00) and ischaemic heart disease (16.54%, SMOR: 1.45, 95% CI: 1.35, 1.64). Conclusion: GCA is associated with increased risk of dying from large-vessel disease, other cardiovascular diseases and potentially treatment-related co-morbidities. These findings help provide better insights into the outcomes of GCA. DA - 2018/06/01/ PY - 2018 DO - 10.1093/rheumatology/key028 DP - PubMed VL - 57 IS - 6 SP - 1047 EP - 1055 J2 - Rheumatology (Oxford) LA - eng SN - 1462-0332 ST - Mortality causes and trends associated with giant cell arteritis KW - Aged KW - Cardiovascular Diseases KW - Cause of Death KW - Comorbidity KW - Databases, Factual KW - Death Certificates KW - Female KW - France KW - Giant Cell Arteritis KW - Humans KW - Male KW - Middle Aged KW - Neoplasms KW - Registries KW - Retrospective Studies KW - Risk Factors KW - Survival Rate ER - TY - JOUR TI - L’acceptabilité de la déclaration d’informations identifiantes dans une enquête transversale en population générale AU - Legleye, Stéphane AU - Richard, Jean-Baptiste AU - Rey, Grégoire AU - Beck, François T2 - Population AB - Les enquêtes téléphoniques en population générale sont indispensables à la description des comportements de santé de la population. Nous avons testé la faisabilité de la demande de deux types de données identifiantes permettant des appariements à des données administratives et médico-administratives dans le Baromètre santé 2014 de Santé publique France : le NIR, numéro d’inscription au répertoire (dit de Sécurité sociale), et les coordonnées de naissance (CDN) comme les nom, prénom, date et lieu de naissance. Chacune était adressée à un sous-échantillon aléatoire de plus de 3000 répondants. L’étude ne portait pas sur la fourniture réelle de ces identifiants mais sur l’intention de le faire. Davantage de personnes accepteraient de communiquer leurs CDN plutôt que leur NIR (51,9 % vs 34,9 %). Les hommes accepteraient plus fréquemment ces propositions et il existe un gradient social au profit des plus diplômés et des cadres (NIR) ou des revenus élevés (NIR et CDN). Les personnes interrogées via un téléphone mobile acceptent moins souvent ces propositions, alors que c’est l’inverse pour celles déclarant des maladies chroniques ou des limitations fonctionnelles, sédentaires, buvant quotidiennement de l’alcool ou s’estimant en mauvaise santé. Les modalités pratiques restent à tester lors d’une prochaine enquête. DA - 2017/// PY - 2017 DP - www.cairn.info VL - Vol. 72 IS - 4 SP - 729 EP - 746 LA - fr SN - 0032-4663 UR - https://www.cairn.info/revue-population-2017-4-page-729.htm Y2 - 2019/03/01/19:21:49 ER - TY - JOUR TI - Reliability of recording uterine cancer in death certification in France and age-specific proportions of deaths from cervix and corpus uteri AU - Rogel, Agnès AU - Belot, Aurélien AU - Suzan, Florence AU - Bossard, Nadine AU - Boussac, Marjorie AU - Arveux, Patrick AU - Buémi, Antoine AU - Colonna, Marc AU - Danzon, Arlette AU - Ganry, Olivier AU - Guizard, Anne-Valérie AU - Grosclaude, Pascale AU - Velten, Michel AU - Jougla, Eric AU - Iwaz, Jean AU - Estève, Jacques AU - Chérié-Challine, Laurence AU - Remontet, Laurent T2 - Cancer epidemiology AB - French uterine cancer recordings in death certificates include 60% of "uterine cancer, Not Otherwise Specified (NOS)"; this hampers the estimation of mortalities from cervix and corpus uteri cancers. The aims of this work were to study the reliability of uterine cancer recordings in death certificates using a case matching with cancer registries and estimate age-specific proportions of deaths from cervix and corpus uteri cancers among all uterine cancer deaths by a statistical approach that uses incidence and survival data. Deaths from uterine cancer between 1989 and 2001 were extracted from the French National database of causes of death and case-to-case matched to women diagnosed with uterine cancer between 1989 and 1997 in 8 cancer registries. Registry data were considered as "gold-standard". Among the 1825 matched deaths, cancer registries recorded 830 cervix and 995 corpus uteri cancers. In death certificates, 5% and 40% of "true" cervix cancers were respectively coded "corpus" and "uterus, NOS" and 5% and 59% of "true" corpus cancers respectively coded "cervix" and "uterus, NOS". Miscoding cervix cancers was more frequent at advanced ages at death and in deaths at home or in small urban areas. Miscoding corpus cancers was more frequent in deaths at home or in small urban areas. From the statistical method, the estimated proportion of deaths from cervix cancer among all uterine cancer deaths was higher than 95% in women aged 30-40 years old but declined to 35% in women older than 70 years. The study clarifies the reason for poor encoding of uterus cancer mortality and refines the estimation of mortalities from cervix and corpus uteri cancers allowing future studies on the efficacy of cervical cancer screening. DA - 2011/06// PY - 2011 DO - 10.1016/j.canep.2010.10.008 DP - NCBI PubMed VL - 35 IS - 3 SP - 243 EP - 249 J2 - Cancer Epidemiol LA - eng SN - 1877-783X KW - Adult KW - Age Factors KW - Aged KW - Aged, 80 and over KW - Data Interpretation, Statistical KW - Female KW - France KW - Humans KW - Middle Aged KW - Registries KW - Reproducibility of Results KW - Survival KW - Uterine Cervical Neoplasms KW - Uterine Neoplasms ER - TY - JOUR TI - Long-term cardiovascular mortality after radiotherapy for breast cancer AU - Bouillon, Kim AU - Haddy, Nadia AU - Delaloge, Suzette AU - Garbay, Jean-Remy AU - Garsi, Jerome-Philippe AU - Brindel, Pauline AU - Mousannif, Abdeddahir AU - Lê, Monique G AU - Labbe, Martine AU - Arriagada, Rodrigo AU - Jougla, Eric AU - Chavaudra, Jean AU - Diallo, Ibrahima AU - Rubino, Carole AU - de Vathaire, Florent T2 - Journal of the American College of Cardiology AB - OBJECTIVES: This study sought to investigate long-term cardiovascular mortality and its relationship to the use of radiotherapy for breast cancer. BACKGROUND: Cardiovascular diseases are among the main long-term complications of radiotherapy, but knowledge is limited regarding long-term risks because published studies have, on average, TY - JOUR TI - Trends in death attributed to heart failure over the past two decades in Europe AU - Laribi, Said AU - Aouba, Albertine AU - Nikolaou, Maria AU - Lassus, Johan AU - Cohen-Solal, Alain AU - Plaisance, Patrick AU - Pavillon, Gérard AU - Jois, Preeti AU - Fonarow, Gregg C AU - Jougla, Eric AU - Mebazaa, Alexandre AU - GREAT network T2 - European journal of heart failure AB - AIMS: Little is known regarding temporal trends in mortality attributed to heart failure (HF) from a population perspective. The aim of this study was to assess the mortality related to HF as an underlying cause during the last 20 years in seven European countries. METHODS AND RESULTS: The number of deaths with HF as the underlying cause was collected in seven European states: Germany, Greece, England and Wales, Spain, France, Finland, and Sweden from 1987 to 2008. Disease coding for HF was based on the International Classification of Diseases (ICD 9th and 10th versions). We computed age-standardized death rates (SDRs) per 100 000 inhabitants. Mean age at death from HF was also calculated for the same period. In the seven studied countries, the HF SDR decreased continuously from 54.2 (1987) to 32.6 (2008). Despite differences in the early 1990s, SDRs related to HF seemed to converge, in these seven European countries, to ∼30 deaths per 100 000 population in the near future, for both men and women. During the study period, the mean age at death increased from 80.0 to 82.7 years. Half of the deaths from HF occurred in hospital, without change over time. CONCLUSION: There has been a 40% reduction of the SDR due to HF in seven European countries during two decades and a concomitant increase in the mean age at death from HF. We hypothesize that these results may be related to a better management of chronic and acute HF patients over the past 20 years. DA - 2012/03// PY - 2012 DO - 10.1093/eurjhf/hfr182 DP - NCBI PubMed VL - 14 IS - 3 SP - 234 EP - 239 J2 - Eur. J. Heart Fail. LA - eng SN - 1879-0844 KW - Age Factors KW - Aged, 80 and over KW - Europe KW - Female KW - Health Status Indicators KW - Heart Failure KW - Humans KW - Internationality KW - Linear Models KW - Male KW - Mortality KW - Time Factors ER - TY - JOUR TI - Epidemiological analysis of health situation development in Europe and its causes until 1990 AU - Zatoński, Witold A AU - HEM project team T2 - Annals of agricultural and environmental medicine: AAEM AB - The enormous health gap between the 'new' (eastern) and 'old' (western) parts of the EU has evolved over many decades. The epidemiological transition - that is the decrease in the relative importance of infant and early child mortality and the shift in the composition of mortality risks from communicable to non-communicable diseases - which started in the western part of the region at the beginning of the 20th century, was substantially delayed in most of eastern Europe. However, after the World War II, health improvement in the east initially out-paced the west, such that, by the mid-1960s, only 1-2 years separated the average life expectancy for both sexes between the east and west. This convergence was short-lived and it reversed dramatically between the mid 1960s and 1990. During this period, adult health status in the east stagnated or deteriorated, whereas in the west it improved steadily: by 1990, life expectancy at the age of 20 years was more than fi ve years shorter in the east for men, and more than four years shorter for women. The biggest contributors to the health gap were cardiovascular diseases and injuries. A substantial fraction of the gap can, with confidence, be attributed to the higher volume and more irregular pattern of alcohol consumption in the east, and to the delayed onset of the tobacco smoking epidemics. Much of the remainder of the gap is likely to be attributable to the composition of the diet, but the contribution of different dietary factors cannot be estimated with confidence. Leading candidates are a high consumption of saturated animal fats, a low consumption of fresh fruit and vegetables (especially in winter and spring), a very low consumption of fats supplying omega 3 fatty acids – both vegetable oils and fi sh oils rich in alpha-linolenic acid – and a high consumption of salt. Behaviours unfavourable to health did not change in the east, as they did in the west in response to the credible dissemination of scientific findings linking disease and injury risks both to individual behaviours and to the social and economic circumstances that fostered those behaviours. The eastern countries failed to equip themselves with the science and with the forms of social organisation that were needed to effectively counter epidemics of chronic disease and injury. The poor health-related behavioural determinants resulted from the institutional infrastructures based on an authoritarian, conservative and medicalised model of health, which inhibited modern approaches to social problems, an almost exclusive focus of epidemiology on communicable as opposed to non-communicable diseases, a lack of understanding and access to modern epidemiology and public health, a lack of understanding and access to evidence-based medicine, and a lack of public health education and health promotion. DA - 2011/12// PY - 2011 DP - NCBI PubMed VL - 18 IS - 2 SP - 194 EP - 202 J2 - Ann Agric Environ Med LA - eng SN - 1898-2263 KW - Adolescent KW - Adult KW - Age Factors KW - Aged KW - Alcohol Drinking KW - Child KW - Child, Preschool KW - Diet KW - Europe KW - Europe, Eastern KW - Female KW - Health Behavior KW - Health education KW - Health promotion KW - History, 20th Century KW - Humans KW - Infant KW - Infant, Newborn KW - Life Expectancy KW - Male KW - Middle Aged KW - Mortality KW - Public health KW - Risk Factors KW - Sex Distribution KW - Smoking KW - Young Adult ER - TY - JOUR TI - Mortality among active-duty male French Armed Forces, 2006-10 AU - Haus-Cheymol, Rachel AU - Boussaud, Marie AU - Jougla, Eric AU - Verret, Catherine AU - Decam, Christophe AU - Pommier de Santi, Vincent AU - Nivoix, Philippe AU - Duron, Sandrine AU - Mayet, Aurélie AU - Dia, Aïssata AU - Meynard, Jean Baptiste AU - Deparis, Xavier AU - Migliani, René AU - Spiegel, André T2 - Journal of public health (Oxford, England) AB - BACKGROUND: In the Armed Forces, knowledge about the causes of deaths is required in order to develop prevention strategies. This study presents the main characteristics of causes of deaths among male active-duty personnel in the French Armed Forces during the 2006-10 period and compares them with the general French male population. METHODS: The data are provided by military public health surveillance. Comparisons of the specific mortality rates (MR) were performed using a Poisson regression. Standardized mortality ratios (SMRs) were calculated to compare mortality with the general French male population. RESULTS: There were 1455 deaths among male active-duty personnel during the study period [MR: 100.9 per 100,000 person-years (PY); 95% confidence interval 95.7-106.1]. The 17-24 age group was characterized by violent deaths: transport accident (MR: 45.9 per 100,000 PY) and suicide (18.8 per 100 000 PY). Overall SMRs show significantly lower MR compared with the French national MR with the exception of SMR for transport accident and suicide in the 17-24 age group. CONCLUSIONS: There is a significantly lower deficit of mortality compared with the French male general population, reflecting a strong healthy worker effect. However, health promotion programmes should continue to put emphasis on transport accident especially among the 17-24 age group. DA - 2012/08// PY - 2012 DO - 10.1093/pubmed/fds016 DP - NCBI PubMed VL - 34 IS - 3 SP - 454 EP - 461 J2 - J Public Health (Oxf) LA - eng SN - 1741-3850 KW - Accidents, Occupational KW - Adolescent KW - Adult KW - Confidence Intervals KW - France KW - Humans KW - Male KW - Middle Aged KW - Military Medicine KW - Military Personnel KW - Mortality KW - Public health KW - Risk Factors KW - Suicide KW - Young Adult ER - TY - JOUR TI - Spatiotemporal association between deprivation and mortality: trends in France during the nineties AU - Windenberger, Fanny AU - Rican, Stéphane AU - Jougla, Eric AU - Rey, Grégoire T2 - European journal of public health AB - BACKGROUND: Monitoring the time course of socio-economic inequalities in mortality is a key public health issue. The aim of this study is to analyse this trend at an ecological level, in mainland France, over the 1990s, using a deprivation index enabling time comparisons. METHODS: Deprivation indexes (FDep) were built using the 1990 and 1999 data and the same methodology. The indices were defined as the first component of a principal component analysis including four specific socio-economic variables. The time course of the association between mortality and deprivation was evaluated on the 'commune' geographic scale (36 000 U in mainland France), without considering spatial autocorrelation and on the larger 'canton' scale (3700 U), considering spatial autocorrelation. The analysis was carried out by gender, age and degree of urbanicity and applied to general mortality and a specific subcategory: 'avoidable' deaths. RESULTS: Area-level socio-economic inequalities in mortality tended to increase during the 1990s. For the period 1997-2001, the standard mortality ratio (SMR) was 24% higher for the communes in the most deprived quintile than for those in the least deprived quintile, while this differential was of 20% for the period 1988-92. This increase in the differentials concerned especially males and people in the age group of TY - JOUR TI - A predictive model relating daily fluctuations in summer temperatures and mortality rates AU - Fouillet, Anne AU - Rey, Grégoire AU - Jougla, Eric AU - Frayssinet, Philippe AU - Bessemoulin, Pierre AU - Hémon, Denis T2 - BMC public health AB - BACKGROUND: In the context of climate change, an efficient alert system to prevent the risk associated with summer heat is necessary. The authors' objective was to describe the temperature-mortality relationship in France over a 29-year period and to define and validate a combination of temperature factors enabling optimum prediction of the daily fluctuations in summer mortality. METHODS: The study addressed the daily mortality rates of subjects aged over 55 years, in France as a whole, from 1975 to 2003. The daily minimum and maximum temperatures consisted in the average values recorded by 97 meteorological stations. For each day, a cumulative variable for the maximum temperature over the preceding 10 days was defined. The mortality rate was modelled using a Poisson regression with over-dispersion and a first-order autoregressive structure and with control for long-term and within-summer seasonal trends. The lag effects of temperature were accounted for by including the preceding 5 days. A "backward" method was used to select the most significant climatic variables. The predictive performance of the model was assessed by comparing the observed and predicted daily mortality rates on a validation period (summer 2003), which was distinct from the calibration period (1975-2002) used to estimate the model. RESULTS: The temperature indicators explained 76% of the total over-dispersion. The greater part of the daily fluctuations in mortality was explained by the interaction between minimum and maximum temperatures, for a day t and the day preceding it. The prediction of mortality during extreme events was greatly improved by including the cumulative variables for maximum temperature, in interaction with the maximum temperatures. The correlation between the observed and estimated mortality ratios was 0.88 in the final model. CONCLUSION: Although France is a large country with geographic heterogeneity in both mortality and temperatures, a strong correlation between the daily fluctuations in mortality and the temperatures in summer on a national scale was observed. The model provided a satisfactory quantitative prediction of the daily mortality both for the days with usual temperatures and for the days during intense heat episodes. The results may contribute to enhancing the alert system for intense heat waves. DA - 2007/// PY - 2007 DO - 10.1186/1471-2458-7-114 DP - NCBI PubMed VL - 7 SP - 114 J2 - BMC Public Health LA - eng SN - 1471-2458 KW - Aged KW - Aged, 80 and over KW - Climate KW - Female KW - Forecasting KW - France KW - Hot Temperature KW - Humans KW - Male KW - Middle Aged KW - Mortality KW - Poisson Distribution KW - Seasons ER - TY - JOUR TI - Evolution of the anaesthetic workload--the French experience AU - Clergue, François AU - Auroy, Yves AU - Pequignot, Françoise AU - Jougla, Eric AU - Lienhart, André AU - Laxenaire, Marie-Claire T2 - Best practice & research. Clinical anaesthesiology AB - The use of anaesthesia has shown major growth during the period 1975-1985. Increases safety in anaesthesia safety have permitted its use in surgery and in other exploratory procedures involving older patients and those with more severe clinical conditions. A survey, designed by the French Society of Anaesthesiologists, collected and analysed data relating to anaesthesia performed in France in 1996 from a representative sample collected in all French hospitals and clinics; the results of this survey were compared with an earlier survey performed in 1980. The participation rate of hospitals was 98%. The results of this survey showed that, between 1980 and 1996, the number of anaesthetic procedures had increased by 120% and the annual rate had increased from 6.6 to 13.5 anaesthetic procedures per 100 population. The annual rate varied between 5.4 per 100 in girls 5-14 years of age and 30.2 per 100 in men 75-84 years of age. The second important phenomenon which occurred between 1980 and 1996 was a marked increase in regional anaesthesia--from 4 to 23% of all cases. This represents a 14-fold increase in the number of cases involving regional anaesthesia. Anaesthesia for obstetric procedures represented 9% of all cases. Seventy-six per cent of all anaesthetics which were started between midnight and 7.00 a.m. were related to obstetric activities. Changes that occurred in the practice of anaesthesia could be explained by changes in the types of procedure requiring anaesthesia: in 1980, 88% of anaesthetics were required for surgical procedures, while in 1996 surgery accounted for 71% of all cases, obstetrics for 9%, and other procedures for the remaining 20%. The practice of epidural anaesthesia for deliveries has developed markedly in France during recent years, increasing from 1.5 to 51% of all deliveries between 1980 and 1996. This survey has offered an interesting overview of recent developments in anaesthesia--which are probably representative of the evolutionary trends in most industrialized countries. These changes can be summarized in three major points: (i) a global increase in the use of anaesthesia related to improvements in its safety; (ii) a significantly increased use of anaesthesia in elderly patients; and (iii) a marked increase in regional anaesthesia. DA - 2002/09// PY - 2002 DP - NCBI PubMed VL - 16 IS - 3 SP - 459 EP - 473 J2 - Best Pract Res Clin Anaesthesiol LA - eng SN - 1521-6896 KW - Adolescent KW - Adult KW - Aged KW - Anesthesia KW - Anesthesia, Conduction KW - Anesthesia, General KW - Anesthesia, Obstetrical KW - Child KW - Child, Preschool KW - Female KW - France KW - Humans KW - Infant KW - Infant, Newborn KW - Male KW - Middle Aged KW - Workload ER - TY - JOUR TI - A French survey of paediatric airway management use in tonsillectomy and appendicectomy AU - Ecoffey, Claude AU - Auroy, Yves AU - Pequignot, Françoise AU - Jougla, Eric AU - Clergue, François AU - Laxenaire, Marie-Claire AU - Lienhart, André T2 - Paediatric anaesthesia AB - BACKGROUND: There are no epidemiological data describing tracheal intubation and laryngeal mask airway (LMATM) use in paediatric anaesthesia. This analysis focused on the factors leading to the indication for an airway management procedure, i.e. tracheal intubation and laryngeal mask airway vs face mask during general anaesthesia for tonsillectomy and appendicectomy. METHODS: The data were recorded in the French survey of Practical Anaesthesia performed in 1996. Two main types of surgical procedures were selected: tonsillectomy and appendicectomy because of the number of patients and the need to use an invasive airway management technique. RESULTS: During a 1-year period, 627 anaesthetics for appendicectomy and 653 anaesthetics for tonsillectomy were recorded in the sample under consideration. Tracheal intubation or laryngeal mask airway was undertaken in 66% of tonsillectomies and 84% of appendicectomies. Univariate analysis showed that tracheal intubation/laryngeal mask were used significantly more often in older children, with long duration of anaesthesia, in nonambulatory procedures and in procedures performed at an academic centre. When these variables were included in a multivariate analysis, the duration of anaesthesia over 30 min was a factor linked to the use of tracheal intubation/laryngeal mask airway for the two types of surgery (P < 0.0001). For tonsillectomy, inpatients were 2.9 times more likely to be intubated (or have an laryngeal mask airway) than were outpatients. For appendicectomy, older children were 3.4 times more likely to be intubated (or have an laryngeal mask airway) than younger children. CONCLUSIONS: This large French survey shows that the use of tracheal intubation/laryngeal mask airway in this country is primarily related to a predicted long duration of anaesthesia. DA - 2003/09// PY - 2003 DP - NCBI PubMed VL - 13 IS - 7 SP - 584 EP - 588 J2 - Paediatr Anaesth LA - eng SN - 1155-5645 KW - Adolescent KW - Age Distribution KW - Anesthesia, General KW - Appendectomy KW - Child KW - Child, Preschool KW - Female KW - France KW - Humans KW - Infant KW - Intubation, Intratracheal KW - Laryngeal Masks KW - Logistic Models KW - Male KW - Masks KW - Time Factors KW - Tonsillectomy ER - TY - JOUR TI - [Larynx cancer in France: descriptive epidemiology and incidence estimation] AU - Peng, Jun AU - Ménégoz, François AU - Lesec'h, Josette Mace AU - Remontet, Laurent AU - Grosclaude, Pascale AU - Buémi, Antoine AU - Guizard, Anne-Valérie AU - Tretarre, Brigitte AU - Danzon, Arlette AU - Velten, Michel AU - Maarouf, Nabil AU - Jougla, Eric AU - Launoy, Guy AU - Dubreuil, Alain T2 - Bulletin du cancer AB - The epidemiology of cancers is known in France through mortality data provided by Inserm and morbidity data obtained by French tumor registries. The purpose of this study was to compare the incidence of laryngeal cancers in 9 French departments and to give an estimate of this incidence for the whole of France, based on this data. Incidence and mortality data were collected over the period 1978-1997. The incidence and mortality rates were estimated for each year from 1978 up to 2000. Observed incidence and mortality data in the population covered by cancer registries were modelled using age-cohort methods. An estimation of the incidence/mortality ratio was obtained from these models and applied to the mortality rates predicted from an age-cohort model for the entire French population. The estimated number of laryngeal cancers was 3,865 in males and 361 in females. There were pronounced contrasts in laryngeal cancer incidence between cancer registries. The incidence rate of laryngeal cancers were especially high in the Somme and Calvados department compared to those observed in Haut-Rhin and Tarn. The ratio incidence/mortality was 2.4 in Doubs and 1.3 in Somme. France is among the countries which have the highest rates of incidence and mortality for laryngeal cancer in Europe. DA - 2004/04// PY - 2004 DP - NCBI PubMed VL - 91 IS - 4 SP - 363 EP - 368 J2 - Bull Cancer LA - fre SN - 0007-4551 ST - [Larynx cancer in France KW - Adult KW - Age Factors KW - Aged KW - Cohort Studies KW - Female KW - France KW - Humans KW - Incidence KW - Laryngeal Neoplasms KW - Male KW - Middle Aged KW - Registries KW - Sex Factors ER - TY - JOUR TI - Mortality related to chronic hepatitis B and chronic hepatitis C in France: evidence for the role of HIV coinfection and alcohol consumption AU - Marcellin, Patrick AU - Pequignot, Françoise AU - Delarocque-Astagneau, Elisabeth AU - Zarski, Jean-Pierre AU - Ganne, Nathalie AU - Hillon, Patrick AU - Antona, Denise AU - Bovet, Martine AU - Mechain, Murielle AU - Asselah, Tarik AU - Desenclos, Jean-Claude AU - Jougla, Eric T2 - Journal of hepatology AB - BACKGROUND/AIMS: Mortality related to HCV and HBV infections was estimated in France. METHODS: A random sample (n=999) of death certificates was obtained from all death certificates listing HBV, HCV, hepatitis, liver disease, possible complication of cirrhosis, bacterial infection, HIV, or transplantation (n=65,000) in France in 2001. Physicians who reported the deaths were sent a questionnaire to identify how many deaths were related to HBV/HCV infection. Completed forms were independently analyzed by a panel of hepatologists. Death rates were estimated according to national population census data. RESULTS: Estimated annual number of deaths associated with HCV and HBV infection was 3618 and 1507, respectively (6.1 and 2.5 deaths per 100,000 inhabitants, respectively). Estimated number of deaths attributable to HCV or HBV infection was 2646 and 1327, respectively (4.5 and 2.2 deaths per 100,000 inhabitants, respectively). In the HCV infection group, 95 percent had cirrhosis; 33 percent had hepatocellular carcinoma (HCC). In the HBV infection group, 93 percent had cirrhosis; 35 percent had HCC. Eleven percent of deaths occurred in patients with HIV coinfection. Deaths related to HBV or HCV infection occurred at an earlier age in patients with a history of excessive alcohol consumption. CONCLUSIONS: In France, 4000-5000 deaths related to HCV and HBV infection occurred in 2001. Alcohol consumption and HIV infection were important co-factors. These data emphasize the need for ongoing, efficient public health programs that include screening, management, and counseling for HCV- and HBV-infected individuals. DA - 2008/02// PY - 2008 DO - 10.1016/j.jhep.2007.09.010 DP - NCBI PubMed VL - 48 IS - 2 SP - 200 EP - 207 J2 - J. Hepatol. LA - eng SN - 0168-8278 ST - Mortality related to chronic hepatitis B and chronic hepatitis C in France KW - Adult KW - Aged KW - Alcohol Drinking KW - Female KW - France KW - HIV Infections KW - Hepatitis B, Chronic KW - Hepatitis C, Chronic KW - Humans KW - Male KW - Middle Aged ER - TY - JOUR TI - Changes in cancer mortality among HIV-infected patients: the Mortalité 2005 Survey AU - Bonnet, Fabrice AU - Burty, Christine AU - Lewden, Charlotte AU - Costagliola, Dominique AU - May, Thierry AU - Bouteloup, Vincent AU - Rosenthal, Eric AU - Jougla, Eric AU - Cacoub, Patrice AU - Salmon, Dominique AU - Chêne, Geneviève AU - Morlat, Philippe AU - Agence Nationale de Recherches sur le Sida et les Hépatites Virales EN19 Mortalité Study Group AU - Mortavic Study Group T2 - Clinical infectious diseases: an official publication of the Infectious Diseases Society of America AB - BACKGROUND: The goal of the current study was to describe the distribution and characteristics of malignancy related deaths among human immunodeficiency virus (HIV)-infected patients with use of data obtained from a national survey conducted in France in 2005 and to compare with results obtained from a similar survey conducted in 2000. METHOD: The underlying cause of death was documented using a standardized questionnaire fulfilled in French hospital wards and networks that were involved in the treatment of HIV-infected patients. RESULTS: Among the 1042 deaths reported in 2005 (964 were reported in 2000), 344 were cancer related (34%), which represented a significant increase from 2000 (29% of deaths were cancer related) (P=.02); 134 of the cancer-related deaths were AIDS related and 210 were not AIDS related. Among the cancer-related causes of death, the proportion of hepatitis-related cancers (6% in 2000 vs. 11% in 2005) and non-AIDS/hepatitis-related cancers (38% in 2000 vs 50% in 2005) significantly increased from 2000 to 2005 (P=.03 and P=.01, respectively), compared with the proportion of cancer that was AIDS related and adjusting for age and sex. Among cases involving AIDS, the proportion of non-Hodgkin lymphoma-associated deaths did not change statistically significantly between 2000 and 2005 (11% and 10% of deaths, respectively). CONCLUSIONS: In this study, an increasing proportion of lethal non-AIDS-related cancers was demonstrated from 2000 to 2005; meanwhile, the proportion of lethal AIDS-related cancers remained stable among HIV-infected patients. Thus, cancer prophylaxis, early diagnosis, and improved management should be included in the routine long-term follow-up of HIV-infected patients. DA - 2009/03/01/ PY - 2009 DP - NCBI PubMed VL - 48 IS - 5 SP - 633 EP - 639 J2 - Clin. Infect. Dis. LA - eng SN - 1537-6591 ST - Changes in cancer mortality among HIV-infected patients KW - Adult KW - Cross-Sectional Studies KW - Female KW - France KW - HIV Infections KW - Humans KW - Male KW - Middle Aged KW - Neoplasms ER - TY - JOUR TI - Emerging role of hepatocellular carcinoma among liver-related causes of deaths in HIV-infected patients: The French national Mortalité 2005 study AU - Salmon-Ceron, Dominique AU - Rosenthal, Eric AU - Lewden, Charlotte AU - Bouteloup, Vincent AU - May, Thierry AU - Burty, Christine AU - Bonnet, Fabrice AU - Costagliola, Dominique AU - Jougla, Eric AU - Semaille, Caroline AU - Morlat, Philippe AU - Cacoub, Patrice AU - Chêne, Geneviève AU - ANRS EN19 Mortalité Study Group and Mortavic T2 - Journal of hepatology AB - BACKGROUND/AIMS: Longer exposure to hepatitis C (HCV) or B virus (HBV) and the increased use of hepatitis treatment might have an impact on liver-related deaths in patients co-infected with the Human Immunodeficiency Virus (HIV). We describe the proportion of liver-related deaths among HIV-infected patients in 2005 compared with 2000. METHODS: In a nationwide survey (341 hospital departments involved in HIV management), all deaths of HIV-infected patients were prospectively reported. Deaths from either cirrhosis, hepatocellular carcinoma or fulminant hepatitis were defined as liver-related deaths. RESULTS: Of the 898 deaths reported in 2005, liver-related causes accounted for 15.4%; this is compared to 13.4% in 2000. Among liver-related deaths, hepatocellular carcinoma increased from 15% to 25% (p=0.04). Among hepatocellular carcinoma-related deaths: in 2000, 10% were HCV-infected; in 2005, 25% were HCV-infected (p=0.03). Half of the HCV-related deaths had been treated for HCV but 98% remained HCV-RNA positive at time of death. The proportion of HBV-related deaths remained stable between 2000 and 2005. CONCLUSIONS: Liver-related deaths, mainly liver cancers, have increased in HIV-infected patients in France despite wide access to HCV treatment. The stability of HBV-related deaths might be explained by the use of dually active antiretroviral drugs in co-infected patients. DA - 2009/04// PY - 2009 DO - 10.1016/j.jhep.2008.11.018 DP - NCBI PubMed VL - 50 IS - 4 SP - 736 EP - 745 J2 - J. Hepatol. LA - eng SN - 1600-0641 ST - Emerging role of hepatocellular carcinoma among liver-related causes of deaths in HIV-infected patients KW - Adult KW - Carcinoma, Hepatocellular KW - Female KW - France KW - HIV Infections KW - Hepatitis B KW - Hepatitis C KW - Heterosexuality KW - Homosexuality KW - Humans KW - Liver Cirrhosis, Alcoholic KW - Liver Neoplasms KW - Male KW - Middle Aged KW - Substance Abuse, Intravenous ER - TY - JOUR TI - Anesthesia-related mortality AU - de Saint Maurice, Guillaume AU - Aouba, Albertine AU - Pequignot, Françoise AU - Auroy, Yves AU - Benhamou, Dan AU - Jougla, Eric AU - Lienhart, André T2 - Anesthesiology DA - 2009/11// PY - 2009 DO - 10.1097/ALN.0b013e3181bbc49b DP - NCBI PubMed VL - 111 IS - 5 SP - 1165; EP - author reply 1166 J2 - Anesthesiology LA - eng SN - 1528-1175 KW - Anesthesia KW - Humans KW - International Classification of Diseases KW - Outcome Assessment (Health Care) ER - TY - JOUR TI - Population-level impact of osteoporotic fractures on mortality and trends over time: a nationwide analysis of vital statistics for France, 1968-2004 AU - Ziadé, Nelly AU - Jougla, Eric AU - Coste, Joël T2 - American journal of epidemiology AB - Osteoporotic fractures are one of the leading causes of death in the elderly population, but mortality may have been reduced by the advances in management and prevention during recent decades. The authors analyzed the population-level impact of these fractures on mortality in France from 1968 to 2004. About 20 million death certificates registered in metropolitan France from 1968 to 2004 were analyzed. Osteoporotic fractures were identified by using a previously developed methodology. Age-specific and standardized mortality rates were calculated by site of fracture and sex, and time trends were evaluated. Associated causes of death were compared between the extreme periods of the study by the observed/expected pairs method; 440,890 (2.2%) death certificates reported an osteoporotic fracture. Osteoporotic fractures overall, particularly hip and skull fractures, declined by half during the study period, exceeding the decline in general mortality and resulting in fracture-deceased subjects being older. However, pelvis, vertebral, and rib fractures became more frequent. Associated causes of death increased with time, except for decubitus ulcers, indicating a change in the pattern of the death process. Despite a 50% decline, osteoporotic fractures still have a significant impact on mortality. The pattern of the death process has changed, with an increased role for comorbidities. DA - 2010/10/15/ PY - 2010 DO - 10.1093/aje/kwq215 DP - NCBI PubMed VL - 172 IS - 8 SP - 942 EP - 951 J2 - Am. J. Epidemiol. LA - eng SN - 1476-6256 ST - Population-level impact of osteoporotic fractures on mortality and trends over time KW - Age Distribution KW - Fractures, Bone KW - France KW - Humans KW - Osteoporosis KW - Sex Distribution KW - Vital Statistics ER - TY - JOUR TI - Anaphylaxis during anesthesia in France: an 8-year national survey AU - Mertes, Paul Michel AU - Alla, François AU - Tréchot, Philippe AU - Auroy, Yves AU - Jougla, Eric AU - Groupe d'Etudes des Réactions Anaphylactoïdes Peranesthésiques T2 - The Journal of allergy and clinical immunology AB - BACKGROUND: More attention should be paid to rare serious adverse events such as anaphylaxis to increase the safety of anesthesia. OBJECTIVE: To report the results of an 8-year survey of anaphylaxis during anesthesia in France. METHODS: Data from patients who experienced anaphylaxis between January 1, 1997, and December 31, 2004, were analyzed. Estimated incidences were obtained by combining this database with data from the French pharmacovigilance system by using a capture-recapture method. The number of patients exposed to the offending agents was obtained from data collected during the national survey of anesthesia practice. RESULTS: A total of 2516 patients was included. A diagnosis of IgE-mediated reaction was established in 1816 cases (72.18%). The most common causes were neuromuscular blocking agents ([NMBAs]; n = 1067; 58.08%), latex (n = 361; 19.65%), and antibiotics (n = 236; 12.85%). The median annual incidence per million procedures was higher for females 154.9 (5th-95th percentile, 117.2-193.1) than for males 55.4 (5th-95th percentile, 42.0-68.0). It reached 250.9 (5th-95th percentile, 189.8-312.9) for women in cases of allergic reactions to NMBAs. In children, a diagnosis of IgE-mediated reactions was obtained in 122 cases (45.9%). The most common causes were latex (n = 51; 41.8%), NMBAs (n = 39; 31.97%), and antibiotics (n = 11; 9.02%). In contrast with adults, no female predominance was observed. CONCLUSION: The incidence of allergic reactions during anesthesia, estimated on a national basis, is higher than previously estimated. These results should be taken into account in the evaluation of the benefit-to-risk ratio of the various anesthetic techniques in individuals. The similar incidence of reactions according to sex before adolescence suggests a role for sex hormones in the increase of anaphylaxis observed in women. DA - 2011/08// PY - 2011 DO - 10.1016/j.jaci.2011.03.003 DP - NCBI PubMed VL - 128 IS - 2 SP - 366 EP - 373 J2 - J. Allergy Clin. Immunol. LA - eng SN - 1097-6825 ST - Anaphylaxis during anesthesia in France KW - Adolescent KW - Adult KW - Anaphylaxis KW - Anesthesia KW - Anesthetics KW - Anti-Bacterial Agents KW - Child KW - Child, Preschool KW - Female KW - France KW - Health Surveys KW - Humans KW - Immunoglobulin E KW - Incidence KW - Male KW - Neuromuscular Blocking Agents KW - Sex Distribution KW - Sex Factors ER - TY - JOUR TI - Impact of the 1998 football World Cup on suicide rates in France: results from the national death registry AU - Encrenaz, Gaëlle AU - Contrand, Benjamin AU - Leffondré, Karen AU - Queinec, Raphaëlle AU - Aouba, Albertine AU - Jougla, Eric AU - Miras, Alain AU - Lagarde, Emmanuel T2 - Suicide & life-threatening behavior AB - Our objective was to determine whether the Fédération Internationale de Football Association (FIFA) World Cup in 1998 had a short-term impact on the number of suicides in France. Exhaustive individual daily data on suicides from 1979 to 2006 were obtained from the French epidemiological center on the medical causes of death (CepiDC-INSERM; France). These data were analyzed using the seasonal ARIMA model. The overall effect of the World Cup was tested together with potential specific impact on days following the French team games. Between 11th June and 11th July, a significant decline of 95 suicides was observed (-10.3%), this effect being the strongest among men and people aged between 30 and 44. A significant decrease was also observed for the days following French team games (-19.9%). Our results are in favor of an effect of nationwide sport events on suicidal behaviors and are consistent with other studies. Many of the theories explaining the relationship between sports and suicide are related to sense of belongingness and social integration, highlighting the importance of social link reinforcement in suicide prevention. DA - 2012/04// PY - 2012 DO - 10.1111/j.1943-278X.2011.00076.x DP - NCBI PubMed VL - 42 IS - 2 SP - 129 EP - 135 J2 - Suicide Life Threat Behav LA - eng SN - 1943-278X ST - Impact of the 1998 football World Cup on suicide rates in France KW - Adolescent KW - Adult KW - Aged KW - Anniversaries and Special Events KW - Female KW - France KW - Humans KW - Interpersonal Relations KW - Male KW - Middle Aged KW - Seasons KW - Soccer KW - Suicide KW - Young Adult ER - TY - JOUR TI - Amenable mortality revisited: the AMIEHS study AU - Hoffmann, Rasmus AU - Plug, Iris AU - Khoshaba, Bernadette AU - McKee, Martin AU - Mackenbach, Johan P AU - AMIEHS working group T2 - Gaceta sanitaria / S.E.S.P.A.S AB - OBJECTIVES: There is a renewed interest in health system indicators. In 1976 a measure of quality of healthcare, amenable mortality, was introduced by Rutstein. This indicator is based on the concept that deaths from certain causes should not occur in the presence of timely and effective healthcare. In the project "Amenable mortality in the European Union: toward better indicators for the effectiveness of health systems" (AMIEHS), we introduce a new approach to the selection of indicators of amenable mortality. METHODS: Based on predefined selection criteria and a broad review of the literature on the effectiveness of medical interventions, a first set of potential indicators of amenable mortality (causes of death) was selected. The timing of the introduction of medical innovations was established through reviews and questionnaires sent to national experts from seven participating European countries. The preselected indicators were then validated by a trend analysis that identified associations between the timing of innovations and cause-specific mortality trends and by a Delphi-procedure. RESULTS: After a short review of previous lists of amenable mortality indicators and a detailed description of the innovative procedure in the AMIEHS project we present a list of 14 causes of death that passed our selection criteria. We illustrate our empirical validation of these indicators using the examples of peptic ulcer and renal failure. CONCLUSIONS: The innovation developed in the AMIEHS study is a rigorous new approach to the concept of amenable mortality that includes empirical validation. Only validated indicators can be successfully used to assess the quality of healthcare systems in international comparisons. DA - 2013/06//May undefined PY - 2013 DO - 10.1016/j.gaceta.2012.08.004 DP - NCBI PubMed VL - 27 IS - 3 SP - 199 EP - 206 J2 - Gac Sanit LA - eng SN - 1578-1283 ST - Amenable mortality revisited ER - TY - JOUR TI - Malignancy-related causes of death in human immunodeficiency virus-infected patients in the era of highly active antiretroviral therapy AU - Bonnet, Fabrice AU - Lewden, Charlotte AU - May, Thierry AU - Heripret, Laurence AU - Jougla, Eric AU - Bevilacqua, Sibylle AU - Costagliola, Dominique AU - Salmon, Dominique AU - Chêne, Geneviève AU - Morlat, Philippe T2 - Cancer AB - BACKGROUND: Before the introduction of highly active antiretroviral therapy (HAART), malignancies accounted for less than 10% of all deaths among human immunodeficiency virus (HIV)-infected patients. This figure may have increased, and the observed types of malignant disease may have been modified, as a result of decreased occurrence of opportunistic infections, the chronicity of HIV infection, the possible oncogenic role of HIV itself, and the aging of the HIV-infected population. METHODS: All French hospital wards involved in the management of HIV infection were asked to prospectively document the deaths of HIV-infected patients in the year 2000. Underlying causes of death were defined using a standardized questionnaire. RESULTS: Of a total of 964 deaths, 269 (28%) were attributable to malignancies. Acquired immunodeficiency virus (AIDS)-related malignancies were the underlying cause of 149 deaths (15%); among these malignancies were non-Hodgkin lymphoma (n = 105 [11%]), noncerebral lymphoma (n = 78 [median CD4 count, 86 x 10(6) per liter; interquartile range [IQR], 35-231 x 10(6) per liter), and primary cerebral lymphoma (n = 27 [median CD4 count, 20 x 10(6) per liter; IQR, 4-109 x 10(6) per liter). Kaposi sarcoma was associated with 40 deaths (4%), and cervical carcinoma was associated with 5 (0.5%). Non-AIDS-related malignancies were the underlying cause of 120 deaths (13%); these non-AIDS-related malignancies included 103 solid tumors (50 respiratory tumors, 19 hepatocarcinomas, 9 digestive tumors, and 6 anal tumors; median CD4 count, 218 x 10(6) per liter; IQR, 108-380 x 10(6) per liter) and 17 hemopathies (12 Hodgkin lymphomas, 4 myeloid leukemias, and 1 myeloma; median CD4 count, 113 x 10(6) per liter; IQR, 56-286 x 10(6) per liter). Compared with patients who died of other causes, patients who died of solid tumors were more likely to be male, to smoke, to be older, and to have higher CD4 counts. CONCLUSIONS: Malignant disease has been a major cause of death among HIV-infected patients in industrialized nations since the introduction of HAART. Whereas lethal hemopathies and Kaposi sarcoma are associated with advanced immunosuppression, lethal solid tumors can occur in patients with controlled HIV infection. DA - 2004/07/15/ PY - 2004 DO - 10.1002/cncr.20354 DP - NCBI PubMed VL - 101 IS - 2 SP - 317 EP - 324 J2 - Cancer LA - eng SN - 0008-543X KW - Acquired Immunodeficiency Syndrome KW - Adult KW - Antiretroviral Therapy, Highly Active KW - Female KW - France KW - HIV Infections KW - Humans KW - Lymphoma, AIDS-Related KW - Lymphoma, Non-Hodgkin KW - Male KW - Middle Aged KW - Neoplasms KW - Prospective Studies ER - TY - JOUR TI - Accidents by ABO incompatibility and other main complications related to blood transfusion in surgical patients: data from the French national survey on anaesthesia-related deaths AU - Benhamou, Dan AU - Lienhart, André AU - Auroy, Yves AU - Péquignot, Françoise AU - Jougla, Eric T2 - Transfusion clinique et biologique: journal de la Société française de transfusion sanguine DA - 2005/11// PY - 2005 DO - 10.1016/j.tracli.2005.10.004 DP - NCBI PubMed VL - 12 IS - 5 SP - 389 EP - 390 J2 - Transfus Clin Biol LA - eng SN - 1246-7820 ST - Accidents by ABO incompatibility and other main complications related to blood transfusion in surgical patients KW - Anesthesia KW - Blood Group Incompatibility KW - Blood Loss, Surgical KW - Blood Transfusion KW - France KW - Health Surveys KW - Humans KW - Malpractice ER - TY - JOUR TI - Childhood leukemia incidence and exposure to indoor radon, terrestrial and cosmic gamma radiation AU - Evrard, Anne-Sophie AU - Hémon, Denis AU - Billon, Solenne AU - Laurier, Dominique AU - Jougla, Eric AU - Tirmarche, Margot AU - Clavel, Jacqueline T2 - Health physics AB - This study was undertaken to evaluate the ecological association between terrestrial and cosmic gamma radiation, indoor radon, and acute leukemia incidence among children under 15 y of age. From 1990 to 2001, 5,330 cases of acute leukemia were registered by the French National Registry of Childhood Leukemia and Lymphoma. Exposure to terrestrial gamma radiation was based on measurements, using thermoluminescent dosimeters, at about 1,000 sites covering all the "Départements." In addition, 8,737 indoor terrestrial gamma dose rate measurements covering 62% of the "Départements" and 13,240 indoor radon concentration measurements covering all the "Départements" were made during a national campaign. Cosmic ray doses were estimated in each of the 36,363 "Communes" of France. There was no evidence of an ecological association between terrestrial gamma dose (range: 0.22-0.90 mSv y) or total gamma dose (range: 0.49-1.28 mSv y) and childhood acute leukemia incidence, for acute myeloid leukemia (AML) or for acute lymphoblastic leukemia (ALL), in univariate or multivariate regression analyses including indoor radon. A significant positive association between indoor radon (range: 22-262 Bq m) and AML incidence among children was observed and remained significant in multivariate regression analyses including either terrestrial gamma dose [SIR per 100 Bq m = 1.29 (1.09-1.53)] or total gamma dose [SIR per 100 Bq m = 1.29 (1.09-1.53)]. The study showed no ecological association between terrestrial gamma radiation and childhood leukemia for the range of variation in gamma dose rates observed in France. The moderate ecological association between childhood AML incidence and indoor radon does not appear to be confounded by terrestrial gamma dose. DA - 2006/06// PY - 2006 DO - 10.1097/01.HP.0000198787.93305.35 DP - NCBI PubMed VL - 90 IS - 6 SP - 569 EP - 579 J2 - Health Phys LA - eng SN - 0017-9078 KW - Air Pollution, Indoor KW - Body Burden KW - Child KW - Child, Preschool KW - Confounding Factors (Epidemiology) KW - Cosmic Radiation KW - Environmental Exposure KW - Female KW - France KW - Gamma Rays KW - Humans KW - Incidence KW - Leukemia, Radiation-Induced KW - Male KW - Radiation Dosage KW - Radon KW - Registries KW - Relative Biological Effectiveness KW - Risk Assessment KW - Risk Factors ER - TY - JOUR TI - Patient blood management and transfusion AU - de Saint Maurice, Guillaume AU - Pequignot, Francoise AU - Auroy, Yves AU - Aouba, Albertine AU - Benhamou, Dan AU - Jougla, Eric AU - Lienhart, André T2 - Anesthesiology DA - 2009/08// PY - 2009 DO - 10.1097/ALN.0b013e3181ac1e43 DP - NCBI PubMed VL - 111 IS - 2 SP - 444 EP - 445; author reply 445-446 J2 - Anesthesiology LA - eng SN - 1528-1175 KW - Blood Transfusion KW - Blood Transfusion, Autologous KW - Disease Progression KW - Erythrocyte Transfusion KW - France KW - Humans KW - Neoplasms ER - TY - JOUR TI - Mortality trends in systemic sclerosis in France and USA, 1980-1998: an age-period-cohort analysis AU - Kernéis, Solen AU - Boëlle, Pierre-Yves AU - Grais, Rebecca Freeman AU - Pavillon, Gérard AU - Jougla, Eric AU - Flahault, Antoine AU - Simonsen, Lone AU - Hanslik, Thomas T2 - European journal of epidemiology AB - We compared trends of Systemic Sclerosis (SS) mortality in France and the USA over the period 1980-1998 and used an Age-Period-Cohort (APC) model to adjust on the age at death of SS patients. All deaths coded with SS as an underlying primary or secondary cause in the national French and US mortality databases from 1980 to 1998 were included in the analysis. SS age-standardized mortality rates increased from 7.2 to 10.3/million in US women (+43%), and from 3 to 3.9/million in French women (+22%). Most of the increase occurred in senior women. In contrast, SS age-standardized death rates remained stable among US men (around 3/million) and French men (around 2/million). In US women, the APC analysis shows a growing cohort effect between 1900 and 1940, tending to stabilize for following cohorts. Similar findings were obtained to a lesser extent in French women. In conclusion, SS mortality rates increased by more than 40% between 1980 and 1998 in the USA, mostly in women born between 1900 and 1940. Whether these trends reflect rising incidence of SS need to be documented. The observed dissimilarity between genders and countries underline that environmental exposure and gender-related factors likely play a major etiological role. Stabilization in the following birth cohorts suggests that the increase of mortality observed since 1980 may slow down in the near future. DA - 2010/// PY - 2010 DO - 10.1007/s10654-009-9403-2 DP - NCBI PubMed VL - 25 IS - 1 SP - 55 EP - 61 J2 - Eur. J. Epidemiol. LA - eng SN - 1573-7284 ST - Mortality trends in systemic sclerosis in France and USA, 1980-1998 KW - Adolescent KW - Adult KW - Aged KW - Aged, 80 and over KW - Child KW - Child, Preschool KW - Cohort Studies KW - Female KW - France KW - Humans KW - Infant KW - Infant, Newborn KW - Male KW - Middle Aged KW - Mortality KW - Retrospective Studies KW - Scleroderma, Systemic KW - United States KW - Young Adult ER - TY - JOUR TI - Innovations in health care and mortality trends from five cancers in seven European countries between 1970 and 2005 AU - Hoffmann, Rasmus AU - Plug, Iris AU - McKee, Martin AU - Khoshaba, Bernadette AU - Westerling, Ragnar AU - Looman, Caspar AU - Rey, Gregoire AU - Jougla, Eric AU - Lang, Katrin AU - Pärna, Kersti AU - Mackenbach, Johan P T2 - International journal of public health AB - OBJECTIVES: Although the contribution of health care to survival from cancer has been studied extensively, much less is known about its contribution to population health. We examine how medical innovations have influenced trends in cause-specific mortality at the national level. METHODS: Based on literature reviews, we selected six innovations with proven effectiveness against cervical cancer, Hodgkin's disease, breast cancer, testicular cancer, and leukaemia. With data on the timing of innovations and cause-specific mortality (1970-2005) from seven European countries we identified associations between innovations and favourable changes in mortality. RESULTS: For none of the five specific cancers, sufficient evidence for an association between introduction of innovations and a positive change in mortality could be found. The highest association was found between the introduction of Tamoxifen and breast cancer mortality. CONCLUSIONS: The lack of evidence of health care effectiveness may be due to gradual improvements in treatment, to effects limited to certain age groups or cancer subtypes, and to contemporaneous changes in cancer incidence. Research on the impact of health care innovations on population health is limited by unreliable data on their introduction. DA - 2013/08/29/ PY - 2013 DO - 10.1007/s00038-013-0507-9 DP - NCBI PubMed J2 - Int J Public Health LA - ENG SN - 1661-8564 ER - TY - JOUR TI - Diverging trends in educational inequalities in cancer mortality between men and women in the 2000s in France AU - Menvielle, Gwenn AU - Rey, Grégoire AU - Jougla, Eric AU - Luce, Danièle T2 - BMC public health AB - BACKGROUND: Socioeconomic inequalities in cancer mortality have been observed in different European countries and the US until the end of the 1990s, with changes over time in the magnitude of these inequalities and contrasted situations between countries. The aim of this study is to estimate relative and absolute educational differences in cancer mortality in France between 1999 and 2007, and to compare these inequalities with those reported during the 1990s. METHODS: Data from a representative sample including 1% of the French population were analysed. Educational differences among people aged 30--74 were quantified with hazard ratios and relative indices of inequality (RII) computed using Cox regression models as well as mortality rate difference and population attributable fraction. RESULTS: In the period 1999--2007, large relative inequalities were found among men for total cancer and smoking and/or alcohol related cancers mortality (lung, head and neck, oesophagus). Among women, educational differences were reported for total cancer, head and neck and uterus cancer mortality. No association was found between education and breast cancer mortality. Slight educational differences in colorectal cancer mortality were observed in men and women. For most frequent cancers, no change was observed in the magnitude of relative inequalities in mortality between the 1990s and the 2000s, although the RII for lung cancer increased both in men and women. Among women, a large increase in absolute inequalities in mortality was observed for all cancers combined, lung, head and neck and colorectal cancer. In contrast, among men, absolute inequalities in mortality decreased for all smoking and/or alcohol related cancers. CONCLUSION: Although social inequalities in cancer mortality are still high among men, an encouraging trend is observed. Among women though, the situation regarding social inequalities is less favourable, mainly due to a health improvement limited to higher educated women. These inequalities may be expected to further increase in future years. DA - 2013/09/10/ PY - 2013 DO - 10.1186/1471-2458-13-823 DP - NCBI PubMed VL - 13 IS - 1 SP - 823 J2 - BMC Public Health LA - ENG SN - 1471-2458 ER - TY - JOUR TI - Reasons for the underreporting of maternal mortality in France, as indicated by a survey of all deaths among women of childbearing age AU - Bouvier-Colle, M H AU - Varnoux, N AU - Costes, P AU - Hatton, F T2 - International Journal of Epidemiology AB - Although maternal mortality is higher in France than in other European countries, hospital data prove that maternal deaths are underestimated. To assess the degree of underestimation and investigate the reasons for it, a retrospective survey was carried out among the certifying doctors of the 3045 deaths that occurred among women aged 15-44 years, from December 1988 to March 1989. Doctors were asked for information on the obstetric condition of the women and their health before death. Some 88.2% of those approached responded. Sociodemographic information was obtained from the French national record of causes of death. Although doctors reported gravid puerperal conditions on 41 death certificates, only 24 deaths were classified in the maternal mortality category of the International Classification of Diseases. The other 17 deaths were classified elsewhere. The present survey permitted the identification of 27 additional deaths of which 16 were considered as having obstetric causes. Of the 68 deaths in pregnant or puerperal women which occurred during the survey period, 54 were classified as having obstetric causes. No sociodemographic differences were found between the deaths registered in the national record and the newly identified maternal deaths. All deaths occurring during or after parturition were reported to the national record, but most of the deaths from abortion were identified from the survey. The discussion deals with the misclassification of maternal deaths and the difficulty of determining the underlying cause of deaths involving complex diseases or uncertain pathogenesis. CN - 0118 DA - 1991/09// PY - 1991 DP - NCBI PubMed VL - 20 IS - 3 SP - 717 EP - 721 J2 - Int J Epidemiol SN - 0300-5771 UR - http://www.ncbi.nlm.nih.gov/pubmed/1955257 Y2 - 2012/06/27/13:16:08 KW - Adolescent KW - Adult KW - Female KW - France KW - Humans KW - Maternal Mortality KW - Pregnancy KW - Pregnancy Complications ER - TY - JOUR TI - [Sudden infant death in France during the winter of 1986] AU - Bouvier-Colle, M H AU - Inizan, J AU - Hugny, B AU - Michel, E AU - Hatton, F T2 - Archives Françaises De Pédiatrie AB - From the statistics of the medical causes of deaths and the results of a retrospective survey carried out among the physicians who certified the deaths, an analysis of post-neonatal mortality during winter of 1986 was undertaken in order to know if the relative part of the sudden infant death syndrome (SIDS) had increased during that winter. It appeared that the deaths attributed to SIDS can be distinguished from deaths of other causes for several factors (place of death, former status of the baby). However, the low number of post mortem examinations performed does not allow in all the declared cases to assess SIDS as internationally defined. However, it is shown that sudden mortality was not higher during this special winter and that immunizations were not more frequently related to this cause than to other causes of death. CN - 0000 DA - 1988/01// PY - 1988 DP - NCBI PubMed VL - 45 IS - 1 SP - 21 EP - 26 J2 - Arch. Fr. Pediatr. SN - 0003-9764 UR - http://www.ncbi.nlm.nih.gov/pubmed/3365100 Y2 - 2012/06/27/13:13:50 KW - France KW - Humans KW - Infant KW - Infant, Newborn KW - Questionnaires KW - Retrospective Studies KW - Seasons KW - Sudden Infant Death ER - TY - JOUR TI - [Mortality and morbidity of drug addiction increases in France] AU - Hatton, F AU - Facy, F AU - Jougla, E T2 - Revue D'épidémiologie Et De Santé Publique CN - 0000 DA - 1993/// PY - 1993 DP - NCBI PubMed VL - 41 IS - 5 SP - 422 EP - 425 J2 - Rev Epidemiol Sante Publique SN - 0398-7620 UR - http://www.ncbi.nlm.nih.gov/pubmed/8284483 Y2 - 2012/06/27/13:19:25 KW - Adult KW - Female KW - France KW - Humans KW - Male KW - Morbidity KW - Population Surveillance KW - Residence Characteristics KW - Socioeconomic Factors KW - Substance-Related Disorders ER - TY - JOUR TI - "Avoidable" mortality and health services: a review of aggregate data studies AU - Mackenbach, J P AU - Bouvier-Colle, M H AU - Jougla, E T2 - Journal of Epidemiology and Community Health AB - STUDY OBJECTIVE The aim of the study was to review published work reporting mortality from conditions amenable to medical intervention and compare the methods used and the results obtained. SOURCE MATERIAL: Two types of analysis were examined: (1) analyses of time trends, relating decline in mortality from amenable conditions to improvements in medical care (3 papers); (2) analyses of geographical variation, either between or within countries, in which mortality was related to the availability of health care resources and to other factors (8 papers). RESULTS Time-trend studies have in general shown that mortality from amenable causes has declined faster over the past decades than most other causes of death. Studies of geographical variation have shown that mortality from amenable causes is consistently associated with socioeconomic factors, and that the association with the provision of health care resources is rather weak and inconsistent. CONCLUSIONS (1) The low levels of mortality from amenable causes which presently prevail in industrialised countries are likely to reflect, at least in part, the increased effectiveness of health services; (2) geographical variation in mortality from amenable causes has not yet been shown to reflect differences in effectiveness of health services; and (3) if geographical variation in avoidable mortality does reflect such differences, they must arise from circumstances other than the level of supply, for example from more specific aspects of health care delivery, and are probably closely related to socioeconomic circumstances. In depth studies at the individual level are now more likely to produce information about factors limiting the effectiveness of health services than further studies of aggregate data. CN - 0164 DA - 1990/06// PY - 1990 DP - NCBI PubMed VL - 44 IS - 2 SP - 106 EP - 111 J2 - J Epidemiol Community Health SN - 0143-005X ST - "Avoidable" mortality and health services UR - http://www.ncbi.nlm.nih.gov/pubmed/2196328 Y2 - 2012/06/27/13:15:46 KW - Health Resources KW - Health Services KW - Humans KW - Mortality KW - Socioeconomic Factors KW - Time Factors ER - TY - JOUR TI - Sudden infant death and immunization: an extensive epidemiological approach to the problem in France--winter 1986 AU - Bouvier-Colle, M H AU - Flahaut, A AU - Messiah, A AU - Jougla, E AU - Hatton, F T2 - International Journal of Epidemiology AB - In March 1986 five sudden infant deaths were reported, following the diphtheria-tetanus toxoids-pertussis and inactivated poliomyelitis virus (DTP-IPV) immunization of the infants concerned. An epidemiological study was carried out in order to investigate the possibility of a relationship between this immunization and sudden infant death syndrome (SIDS). A detailed examination of the five cases had been carried out by a doctor. An exhaustive survey of all postneonatal deaths occurring between January and March 1986 was conducted and also a matched case-control survey. No significant differences were found in the immunization rates between SIDS and other causes of death, nor between SIDS and living controls. These results are compared with the results from previously published studies on the topic. CN - 0029 DA - 1989/03// PY - 1989 DP - NCBI PubMed VL - 18 IS - 1 SP - 121 EP - 126 J2 - Int J Epidemiol SN - 0300-5771 ST - Sudden infant death and immunization UR - http://www.ncbi.nlm.nih.gov/pubmed/2722354 Y2 - 2012/06/27/13:12:37 KW - Autopsy KW - Diphtheria Toxoid KW - Diphtheria-Tetanus-Pertussis Vaccine KW - Drug Combinations KW - Epidemiologic Methods KW - Female KW - France KW - Hospitalization KW - Humans KW - Infant KW - Male KW - Pertussis Vaccine KW - Poliovirus Vaccine, Inactivated KW - Seasons KW - Sudden Infant Death KW - Tetanus Toxoid KW - Vaccines, Combined ER - TY - JOUR TI - [Trends in mortality characteristics in Aids in France 1983-1990] AU - Jougla, E AU - Hatton, F AU - Le Toullec, A AU - Michel, E T2 - Revue D'épidémiologie Et De Santé Publique AB - From 1983 to 1990, the number of AIDS deaths in France (8119 deaths overall), increased substnatially but the annual rate of progression has fallen since 1987 (+35% in 1990). The socio-demographic characteristics of the deaths remained quite steady with the exception of the proportion of subjects living in Paris which decreased. The proportion of AIDS deaths out of all deaths is still low for the entire population (5 deaths out of 1000 in 1990) but appears important in some sub-groups. In 1990, AIDS represents for the 25-34 years old group, 12 deaths out of 100 for males and 7 deaths out of 100 for females and for the 25-44 years old group, 15 deaths out of 100 for nonmarried males and 4 deaths out of 10 for males working in an information or artistic profession. Furthermore, it accounts, in 1989, for the third of the deaths of males between 25 and 44 years living in Paris. The analyse tends to show that there is not an important under-declaration of AIDS deaths in France. CN - 0000 DA - 1992/// PY - 1992 DP - NCBI PubMed VL - 40 IS - 3 SP - 164 EP - 174 J2 - Rev Epidemiol Sante Publique SN - 0398-7620 UR - http://www.ncbi.nlm.nih.gov/pubmed/1439058 Y2 - 2012/06/27/13:17:53 KW - Acquired Immunodeficiency Syndrome KW - Adult KW - Female KW - Humans KW - Male KW - Middle Aged KW - Socioeconomic Factors KW - Urban Population KW - demography ER - TY - JOUR TI - [Space-time clustering of sudden infant death in France from 1981 to 1986] AU - Larroque, B AU - Bouvier-Colle, M H AU - Hatton, F T2 - Revue D'épidémiologie Et De Santé Publique AB - In tempered countries, higher sudden infant death rates are observed during winters, which is in favor of an infectious factor in the etiology. According to the geographic regions, the rates of SIDS are showing a downward gradient from the north of France to the south. In an attempt to assess the infectious hypothesis, we carried out a research about space-time clusters of Sudden infant deaths. The Knox's méthode was used with data of the medical causes of death registered in France from 1981-82 to 1985-86, by areas. Clusters were found in several regions, but they are moving from one year to another. The interpretation of these findings remains difficult because of the large number of tests. CN - 0000 DA - 1991/// PY - 1991 DP - NCBI PubMed VL - 39 IS - 1 SP - 45 EP - 54 J2 - Rev Epidemiol Sante Publique SN - 0398-7620 UR - http://www.ncbi.nlm.nih.gov/pubmed/2031096 Y2 - 2012/06/27/13:16:43 KW - Cluster Analysis KW - Data Interpretation, Statistical KW - France KW - Humans KW - Infant KW - Sudden Infant Death KW - demography ER - TY - JOUR TI - [Relation between the level of the development of the care system and the level of "preventable" mortality according to department in France] AU - Jougla, E AU - Ducimetière, P AU - Bouvier-Colle, M H AU - Hatton, F T2 - Revue D'épidémiologie Et De Santé Publique AB - "Avoidable" mortality may be defined as a selection of causes of death whose occurrence is closely related to medical intervention. We have attempted to relate the variations in mortality from these selected causes to health service input among the 95 French departments. This analysis was controlled for social factors. Firstly we performed independently two factor analysis of the departmental variations in health care variables and in social factors. These studies were carried out with the aim of creating new discriminant and independent variables. Multiple stepwise regressions were then used to analyse the independent and joint associations of these new variables with mortality. The data show principally the considerable weight of social factors in explaining mortality differences. On the contrary, we found very weak relationships between health service input and mortality. However in view of the analysis method, it would appear unjustified to interpret this result in terms of a criticism of the "avoidable" mortality concept. CN - 0003 DA - 1987/// PY - 1987 DP - NCBI PubMed VL - 35 IS - 5 SP - 365 EP - 377 J2 - Rev Epidemiol Sante Publique SN - 0398-7620 UR - http://www.ncbi.nlm.nih.gov/pubmed/3432706 Y2 - 2012/06/27/13:11:15 KW - Adolescent KW - Adult KW - Child KW - Child, Preschool KW - Delivery of Health Care KW - Female KW - France KW - Humans KW - Male KW - Middle Aged KW - Mortality KW - Primary Prevention KW - Sex Factors KW - Socioeconomic Factors ER - TY - JOUR TI - European study of the certification and coding of causes of death of six clinical case histories of diabetic patients. EURODIAB Subarea C Study Group AU - Balkau, B AU - Jougla, E AU - Papoz, L T2 - International Journal of Epidemiology AB - This study was designed to investigate the large differences in diabetes mortality rates in Europe. In each of the participating countries (France, Germany, The Netherlands, Northern Ireland-UK, Republic of Ireland, Romania, Scotland-UK, Switzerland) a random sample of certifying physicians was asked to certify the causes of death of six case histories which described the deaths of diabetic patients; the responses from an average of 220 physicians per country were analysed. These registered causes were then coded nationally and the underlying cause was compared with that following a central recoding. Overall 28% of the physicians surveyed recorded diabetes on the death certificate as the underlying cause of death--France was 25% below this overall average and Germany 21% above. The national coding of diabetes as the underlying cause of death differed from the central recoding with a comparative undercoding of almost 40% in Romania, 30% in Northern Ireland and 25% in Switzerland; in contrast, there was an overcoding of diabetes by 80% in The Netherlands and 60% in the Republic of Ireland. After adjusting for central recoding, in part an adjustment for certification habits, the national coding from this simulation study was able to explain 35% of the variation in the diabetes mortality rates. With such differences in the coding of diabetes, the currently published mortality rates for diabetes are not directly comparable between European countries; some suggestions are made for the reduction of the intercountry differences in the collection and analysis of mortality data for diabetes. CN - 0000 DA - 1993/02// PY - 1993 DP - NCBI PubMed VL - 22 IS - 1 SP - 116 EP - 126 J2 - Int J Epidemiol SN - 0300-5771 UR - http://www.ncbi.nlm.nih.gov/pubmed/8449631 Y2 - 2012/06/27/13:18:59 KW - Abstracting and Indexing as Topic KW - Adolescent KW - Aged KW - Aged, 80 and over KW - Diabetes Mellitus KW - Europe KW - Female KW - Humans KW - Male KW - Middle Aged KW - Questionnaires KW - Registries ER - TY - JOUR TI - Death certificate coding practices related to diabetes in European countries--the 'EURODIAB Subarea C' Study AU - Jougla, E AU - Papoz, L AU - Balkau, B AU - Maguin, P AU - Hatton, F T2 - International Journal of Epidemiology AB - The objective of this study was to compare and analyse coding practices for diabetes mortality data in nine European countries (Belgium, Republic of Ireland, France, Germany, Malta, The Netherlands, Northern Ireland, Scotland and Switzerland). In each country, a sample of 200 coded death certificates, which mentioned diabetes, was randomly sampled. All death certificates were recoded at the WHO Collaborating Centre for the Classification of Diseases in the French language. The results show wide differences between national coding and central coding. Discrepancies in the underlying cause of death existed at the 3-digit coding level for 26% of all death certificates and for 44% at the 4-digit level. Coding in Northern Ireland and Malta was characterized by a marked tendency to choose diabetes less frequently. In contrast, in The Netherlands and, to a lesser extent, in the Republic of Ireland and France, diabetes was more frequently selected as the underlying cause of death. Most of the differences concerned the coding of an association involving diabetes and circulatory system diseases. In some countries, these coding differences influence the reported level of diabetes mortality. For Northern Ireland and Malta, the number of certificates with diabetes as the underlying cause of death was more than doubled after central recoding and for The Netherlands, in contrast, it was almost halved. To explain the differences a number of factors are considered: a lack of information from the International Classification of Diseases (ICD), on the application of the coding rules, between-country differences in cause of death certification practices, a divergence of opinion about the causal role of diabetes when it is associated with other conditions, a lack of homogeneity between countries in data collection procedures.(ABSTRACT TRUNCATED AT 250 WORDS) CN - 0050 DA - 1992/04// PY - 1992 DP - NCBI PubMed VL - 21 IS - 2 SP - 343 EP - 351 J2 - Int J Epidemiol SN - 0300-5771 UR - http://www.ncbi.nlm.nih.gov/pubmed/1428491 Y2 - 2012/06/27/13:17:37 KW - Data Collection KW - Diabetes Mellitus KW - Europe KW - Humans KW - International Cooperation KW - World Health Organization ER - TY - JOUR TI - [Relationship between the development of the health status and the activity of the health care system in developed countries] AU - Jougla, E AU - Goldberg, M AU - Hatton, F AU - Klein, N AU - Letoullec, A T2 - Revue D'épidémiologie Et De Santé Publique AB - The question of the relationship between the evolution of health status and the activity of health care system in developed countries is treated frequently through epidemiological studies. However, there are numerous methodological difficulties linked to this type of investigation and it is not possible to give a certain answer to this question. Particular difficulties concern the choice of indicators (indicators of health status and indicators of health care system). This choice may influence largely the outcome of the results. If general mortality has tended to decline over the last thirty years, some causes of death have progressed and many studies show an increase of the level of morbidity and disabilities declared in the population and an increase of social disparities in health status. The analysis concerning the role of health care systems, in order to explain this evolution, does not lead to a single conclusion. Some works show the positive effect of the activity of health care systems (especially for infant mortality). According to other authors, the growth of chronic diseases must be considered as the negative aspect of the success obtained in the struggle against mortality. But above all, interpretation of results needs a continuous reference to methodologies used and it is only on this condition that such data may be useful for public health decisions. CN - 0000 DA - 1988/// PY - 1988 DP - NCBI PubMed VL - 36 IS - 6 SP - 464 EP - 484 J2 - Rev Epidemiol Sante Publique SN - 0398-7620 UR - http://www.ncbi.nlm.nih.gov/pubmed/3068725 Y2 - 2012/06/27/13:12:17 KW - Aged KW - Delivery of Health Care KW - Europe KW - Female KW - Health Status Indicators KW - Health Surveys KW - Humans KW - Infant KW - Infant Mortality KW - Infant, Newborn KW - Male KW - Middle Aged KW - Morbidity KW - Mortality KW - Population Surveillance KW - Socioeconomic Factors KW - United States ER - TY - JOUR TI - Sudden infant death syndrome and diphtheria/tetanus toxoid/pertussis/poliomyelitis immunisation AU - Flahault, A AU - Messiah, A AU - Jougla, E AU - Bouvet, E AU - Perin, J AU - Hatton, F T2 - Lancet CN - 0015 DA - 1988/03/12/ PY - 1988 DP - NCBI PubMed VL - 1 IS - 8585 SP - 582 EP - 583 J2 - Lancet SN - 0140-6736 UR - http://www.ncbi.nlm.nih.gov/pubmed/2894508 Y2 - 2012/06/27/13:11:54 KW - Diphtheria Toxoid KW - Diphtheria-Tetanus-Pertussis Vaccine KW - Drug Combinations KW - Female KW - France KW - Humans KW - Infant KW - Male KW - Pertussis Vaccine KW - Poliovirus Vaccine, Inactivated KW - Sudden Infant Death KW - Tetanus Toxoid KW - Time Factors KW - Vaccines, Combined ER - TY - JOUR TI - [Analysis of diabetes-related mortality in France (1970-1987) from multiple causes of death] AU - Jougla, E AU - Papoz, L AU - Balkau, B AU - Simon, D AU - Vauzelle-Kervroedan, F AU - Hatton, F T2 - Diabète & Métabolisme AB - The aim of this study was to analyse the characteristics and the mortality rate of diabetic patients, in France, between 1970 and 1987, as well as the association between diabetes and other pathologies at death. These results are based on both the underlying and the associated causes of death registered on the death certificate, in contrast to most studies which use only the underlying cause. In 1987, there were 16,790 deaths in France for which diabetes was mentioned on the death certificate (as the underlying cause in 38% of cases). There was a higher mortality in male diabetic subjects then in female, for all ages except over 75 years. Between 1970 and 1987, the mortality decreased for both sexes, except for the oldest age group. The death rate varied greatly between geographical regions. A particularly high mortality occurred in the Nord-Pas-de-Calais, Lorraine and Alsace. Diabetes was significantly associated, at death, with other diseases and pathologies. The most frequent were vascular diseases (ischaemic heart disease, cerebral diseases and hypertension) and diseases of the genitourinary system. It if of note that 5% of the death certificates of these diabetic subjects indicated diabetic coma as a cause of death. CN - 0006 DA - 1991/06//May undefined PY - 1991 DP - NCBI PubMed VL - 17 IS - 3 SP - 337 EP - 345 J2 - Diabete Metab SN - 0338-1684 UR - http://www.ncbi.nlm.nih.gov/pubmed/1884877 Y2 - 2012/06/27/13:16:23 KW - Adult KW - Age Factors KW - Aged KW - Diabetes Complications KW - Diabetes Mellitus KW - Female KW - France KW - Humans KW - Male KW - Middle Aged KW - Sex Characteristics KW - demography ER - TY - JOUR TI - A New Approach to Compare the Performance of Two Classification Methods of Causes of Death for Timely Surveillance in France AU - Baghdadi, Yasmine AU - Bourrée, Alix AU - Robert, Aude AU - Rey, Grégoire AU - Gallay, Anne AU - Zweigenbaum, Pierre AU - Grouin, Cyril AU - Fouillet, Anne T2 - Studies in Health Technology and Informatics AB - Timely mortality surveillance in France is based on the monitoring of electronic death certificates to provide information to health authorities. This study aims to analyze the performance of a rule-based and a supervised machine learning method to classify medical causes of death into 60 mortality syndromic groups (MSGs). Performance was first measured on a test set. Then we compared the trends of the monthly numbers of deaths classified into MSGs from 2012 to 2016 using both methods. Among the 60 MSGs, 31 achieved recall and precision over 0.95 for either one or the other method on the test set. On the whole dataset, the correlation coefficient of the monthly numbers of deaths obtained by the two methods were close to 1 for 21 of the 31 MSGs. This approach is useful for analyzing a large number of categories or when annotated resources are limited. DA - 2019/08/21/ PY - 2019 DO - 10.3233/SHTI190359 DP - PubMed VL - 264 SP - 925 EP - 929 J2 - Stud Health Technol Inform LA - eng SN - 1879-8365 KW - Cause of Death KW - Death Certificates KW - France KW - Health Resources KW - Humans KW - Machine learning KW - Supervised Machine Learning KW - cause of death KW - sentinel surveillance ER - TY - JOUR TI - Ecological association between a deprivation index and mortality in France over the period 1997 - 2001: variations with spatial scale, degree of urbanicity, age, gender and cause of death AU - Rey, Grégoire AU - Jougla, Eric AU - Fouillet, Anne AU - Hémon, Denis T2 - BMC public health AB - BACKGROUND: Spatial health inequalities have often been analysed in terms of deprivation. The aim of this study was to create an ecological deprivation index and evaluate its association with mortality over the entire mainland France territory. More specifically, the variations with the degree of urbanicity, spatial scale, age, gender and cause of death, which influence the association between mortality and deprivation, have been described. METHODS: The deprivation index, 'FDep99', was developed at the 'commune'(smallest administrative unit in France) level as the first component of a principal component analysis of four socioeconomic variables. Proxies of the Carstairs and Townsend indices were calculated for comparison. The spatial association between FDep99 and mortality was studied using five different spatial scales, and by degree of urbanicity (five urban unit categories), age, gender and cause of death, over the period 1997-2001. 'Avoidable' causes of death were also considered for subjects aged less than 65 years. They were defined as causes related to risk behaviour and primary prevention (alcohol, smoking, accidents). RESULTS: The association between the FDep99 index and mortality was positive and quasi-log-linear, for all geographic scales. The standardized mortality ratio (SMR) was 24% higher for the communes of the most deprived quintile than for those of the least deprived quintile. The between-urban unit category and between-région heterogeneities of the log-linear associations were not statistically significant. The association was positive for all the categories studied and was significantly greater for subjects aged less than 65 years, for men, and for 'avoidable' mortality. The amplitude and regularity of the associations between mortality and the Townsend and Carstairs indices were lower. CONCLUSION: The deprivation index proposed reflects a major part of spatial socioeconomic heterogeneity, in a homogeneous manner over the whole country. The index may be routinely used by healthcare authorities to observe, analyse, and manage spatial health inequalities. DA - 2009/// PY - 2009 DO - 10.1186/1471-2458-9-33 DP - NCBI PubMed VL - 9 SP - 33 J2 - BMC Public Health LA - eng SN - 1471-2458 ST - Ecological association between a deprivation index and mortality in France over the period 1997 - 2001 KW - Adult KW - Age Factors KW - Aged KW - Aged, 80 and over KW - Female KW - France KW - Health Status Disparities KW - Health Status Indicators KW - Health Surveys KW - Humans KW - Male KW - Middle Aged KW - Mortality KW - Risk Assessment KW - Sex Factors KW - Socioeconomic Factors KW - Urban Population KW - Young Adult ER - TY - JOUR TI - Deaths with asthma in France, 2000-2005: a multiple-cause analysis AU - Fuhrman, Claire AU - Jougla, Eric AU - Uhry, Zoé AU - Delmas, Marie-Christine T2 - The Journal of asthma: official journal of the Association for the Care of Asthma AB - Mortality from asthma has decreased in many countries since the 1990s. Mortality statistics are usually based only on the underlying cause of death. The objectives of this study were to describe the characteristics of deaths and the trends in asthma-related mortality using multiple-cause analysis. Data were obtained from the French Centre of Epidemiology on Medical Causes of Death. Because ICD-10 was implemented in 2000, the analysis covers the period 2000-2005. In 2004-2005, asthma was the underlying cause of 42% of deaths with certificates mentioning asthma. The age-standardised rates of death from asthma decreased from 2000 through 2005 (-12% and -11%/year in the 1-44 and 45-64 age groups, respectively). The decline for all deaths with asthma was less pronounced (-9%/year in the 1-44 age group and -8%/year in the 45-64). Among adults aged 65 or older, the decrease in asthma-related mortality was higher in men (-12%/year for underlying cause, -9% for multiple-cause) than women (-5% and -3%, respectively). Since 2002, age-standardised rates of asthma-related mortality have been higher in women than men. In people aged 1-44 years, in-hospital deaths have declined between 2000 and 2005 while the proportion of non-hospital deaths increased from 53% to 67%. Regardless of the definition used, the age-standardised rate of asthma-related deaths decreased from 2000 to 2005, and the faster decline for underlying cause than for multiple-cause mortality argues for a real decline in mortality attributable to asthma. Using multiple cause-of-death analysis provides additional information for asthma mortality surveillance. DA - 2009/05// PY - 2009 DO - 10.1080/02770900902795553 DP - NCBI PubMed VL - 46 IS - 4 SP - 402 EP - 406 J2 - J Asthma LA - eng SN - 1532-4303 ST - Deaths with asthma in France, 2000-2005 KW - Adolescent KW - Adult KW - Age Distribution KW - Asthma KW - Child KW - Child, Preschool KW - Comorbidity KW - Cross-Sectional Studies KW - Female KW - France KW - Hospital Mortality KW - Humans KW - Incidence KW - Male KW - Middle Aged KW - Mortality KW - Registries KW - Risk Assessment KW - Severity of Illness Index KW - Sex Distribution KW - Young Adult ER - TY - JOUR TI - Causes of deaths data, linkages and big data perspectives AU - Rey, Grégoire AU - Bounebache, Karim AU - Rondet, Claire T2 - Journal of Forensic and Legal Medicine AB - The study of cause-specific mortality data is one of the main sources of information for public health monitoring. In most industrialized countries, when a death occurs, it is a legal requirement that a medical certificate based on the international form recommended by World Health Organization's (WHO) is filled in by a physician. The physician reports the causes of death that directly led or contributed to the death on the death certificate. The death certificate is then forwarded to a coding office, where each cause is coded, and one underlying cause is defined, using the rules of the International Classification of Diseases and Related Health Problems, now in its 10th Revision (ICD-10). Recently, a growing number of countries have adopted, or have decided to adopt, the coding software Iris, developed and maintained by an international consortium1. This whole standardized production process results in a high and constantly increasing international comparability of cause-specific mortality data. While these data could be used for international comparisons and benchmarking of global burden of diseases, quality of care and prevention policies, there are also many other ways and methods to explore their richness, especially when they are linked with other data sources. Some of these methods are potentially referring to the so-called "big data" field. These methods could be applied both to the production of the data, to the statistical processing of the data, and even more to process these data linked to other databases. In the present note, we depict the main domains in which this new field of methods could be applied. We focus specifically on the context of France, a 65 million inhabitants country with a centralized health data system. Finally we will insist on the importance of data quality, and the specific problematics related to death certification in the forensic medicine domain. DA - 2018/07// PY - 2018 DO - 10.1016/j.jflm.2016.12.004 DP - PubMed VL - 57 SP - 37 EP - 40 J2 - J Forensic Leg Med LA - eng SN - 1878-7487 KW - Big data KW - Cause of Death KW - Causes of death data KW - Data Mining KW - Data linkages KW - Datasets as Topic KW - Death Certificates KW - France KW - Humans KW - International Classification of Diseases KW - Software ER - TY - JOUR TI - Automatic classification of free-text medical causes from death certificates for reactive mortality surveillance in France AU - Baghdadi, Yasmine AU - Bourrée, Alix AU - Robert, Aude AU - Rey, Grégoire AU - Gallay, Anne AU - Zweigenbaum, Pierre AU - Grouin, Cyril AU - Fouillet, Anne T2 - International Journal of Medical Informatics AB - BACKGROUND: Mortality surveillance is of fundamental importance to public health surveillance. The real-time recording of death certificates, thanks to Electronic Death Registration System (EDRS), provides valuable data for reactive mortality surveillance based on medical causes of death in free-text format. Reactive mortality surveillance is based on the monitoring of mortality syndromic groups (MSGs). An MSG is a cluster of medical causes of death (pathologies, syndromes or symptoms) that meets the objectives of early detection and impact assessment of public health events. The aim of this study is to implement and measure the performance of a rule-based method and two supervised models for automatic free-text cause of death classification from death certificates in order to implement them for routine surveillance. METHOD: A rule-based method was implemented using four processing steps: standardization rules, splitting causes of death using delimiters, spelling corrections and dictionary projection. A supervised machine learning method using a linear Support Vector Machine (SVM) classifier was also implemented. Two models were produced using different features (SVM1 based solely on surface features and SVM2 combining surface features and MSGs classified by the rule-based method as feature vectors). The evaluation was conducted using an annotated subset of electronic death certificates received between 2012 and 2016. Classification performance was evaluated on seven MSGs (Influenza, Low respiratory diseases, Asphyxia/abnormal respiration, Acute respiratory disease, Sepsis, Chronic digestive diseases, and Chronic endocrine diseases). RESULTS: The rule-based method and the SVM2 model displayed a high performance with F-measures over 0.94 for all MSGs. Precision and recall were slightly higher for the rule-based method and the SVM2 model. An error-analysis shows that errors were not specific to an MSG. CONCLUSION: The high performance of the rule-based method and SVM2 model will allow us to set-up a reactive mortality surveillance system based on free-text death certificates. This surveillance will be an added-value for public health decision making. DA - 2019//11/ PY - 2019 DO - 10.1016/j.ijmedinf.2019.06.022 DP - PubMed VL - 131 SP - 103915 J2 - Int J Med Inform LA - eng SN - 1872-8243 KW - Automatic classification KW - Evaluation performance KW - Medical causes of death KW - Rule-based method KW - SVM KW - Syndromic surveillance ER - TY - JOUR TI - A Note on the Measurement of Socioeconomic Inequalities in Life Years Lost by Cause of Death AU - Latouche, Aurélien AU - Andersen, Per Kragh AU - Rey, Grégoire AU - Moreno-Betancur, Margarita T2 - Epidemiology (Cambridge, Mass.) AB - Quantifying socioeconomic inequalities in health in absolute terms is of prime interest for decision-making and for international comparisons. The Slope Index of Inequality (SII), an index that quantifies absolute socioeconomic inequalities, was recently formalized, particularly in the context of mortality differences measured in the rate or hazard scale. However, absolute inequalities using either rates or hazards do not translate into a time dimension, which makes their interpretation difficult for policymakers. We propose an extension of the SII in terms of the expected number of life years lost before an upper age, as well as its decomposition by cause of death. The SII in the life years lost metric quantifies the extent to which life expectancy is shortened when comparing the higher and lower ends of the socioeconomic scale. The methodology proposed builds on recent developments in survival analysis for decomposing the number of life years lost according to cause of death using a pseudo-value approach. We illustrate our proposal using a representative 1% sample of the French population. On average, the least educated men lost 7 years of life from age 30 up to age 90 compared to the most educated. The loss for women is twice as much with 3.5 years. The SII in the life years lost metric is easily understood, and the decomposition of the all-cause mortality SII into parts attributable to given causes provides a sound estimation of the burden of different causes of death on absolute socioeconomic inequalities in mortality. DA - 2019/06/11/ PY - 2019 DO - 10.1097/EDE.0000000000001022 DP - PubMed J2 - Epidemiology LA - eng SN - 1531-5487 ER - TY - JOUR TI - Study of the Usability of an Automated Coding Software for Causes of Death in an African Context AU - Barro, Seydou Golo AU - Rey, Grégoire AU - Staccin, Pascal T2 - Studies in Health Technology and Informatics AB - IRIS is an automated coding software for the causes of death. It is used in many European countries for the production of death statistics. The purpose of our work was to study the usability of this software in Africa where the quality of statistics is insufficient. For this, we have developed a device consisting of two software: "collector" and "encoder" cooperating via the same database. DA - 2019/08/21/ PY - 2019 DO - 10.3233/SHTI190743 DP - PubMed VL - 264 SP - 1978 EP - 1979 J2 - Stud Health Technol Inform LA - eng SN - 1879-8365 KW - Africa KW - Automated Data Processing KW - Cause of Death KW - Databases, Factual KW - Europe KW - Software KW - User-Computer Interface ER - TY - JOUR TI - Risk of suicide attempt associated with isotretinoin: a nationwide cohort and nested case-time-control study AU - Droitcourt, Catherine AU - Nowak, Emmanuel AU - Rault, Caroline AU - Happe, André AU - Le Nautout, Béranger AU - Kerbrat, Sandrine AU - Balusson, Frédéric AU - Poizeau, Florence AU - Travers, David AU - Sapori, Jean-Marc AU - Lagarde, Emmanuel AU - Rey, Grégoire AU - Guillot, Bernard AU - Oger, Emmanuel AU - Dupuy, Alain T2 - International Journal of Epidemiology AB - BACKGROUND: Isotretinoin is the only effective treatment for severe acne. An isotretinoin-related suicide risk is still debated and under scrutiny by regulatory agencies. Our objectives were: to assess the risk of suicide attempt before, during and after isotretinoin treatment; to detect any potential triggering effect of isotretinoin initiation on suicide attempt. METHODS: We implemented a cohort and nested case-time-control study of subjects treated with oral isotretinoin (course or initiation) aged 10-50 years, using the Nationwide French Health Insurance data (2009-2016). The main outcome was hospitalized suicide attempt. Standardized incidence ratios for hospitalized suicide attempts were calculated before, during and after isotretinoin treatment. The number of isotretinoin initiations was compared in risk and control periods of 2 months using a case-time-control analysis. RESULTS: In all, 443 814 patients (median age 20.0 years; interquartile range 17.0-27.0 years) were exposed to isotretinoin, amounting to 244 154 person-years, with a marked seasonality for treatment initiation. Compared with the French general population, the occurrence of suicide attempts under isotretinoin treatment was markedly lower, with a standardized incidence ratio of 0.6 [95% confidence interval (CI) = 0.53-0.67]; the same applied, to a lesser extent, before and after isotretinoin treatment. In the case-time-control analysis, among cases of suicide attempt, 108 and 127 isotretinoin initiations were observed in the risk and control periods respectively (i.e. 0-2 months and 2-4 months before the date of suicide attempt). The comparison with the 1199 and 1253 initiations observed among matched controls in the same two periods yielded a case-time-control odds ratio of 0.89 (95% CI = 0.68-1.16). A sensitivity analysis using three-month periods and a complementary analysis adding completed suicides for case definition showed consistent results. CONCLUSION: Compared with the general population, a lower risk of suicide attempt was observed among patients exposed to isotretinoin and there was no evidence for a triggering effect of isotretinoin initiation on suicide attempt. A selection of patients at lower risk for suicidal behaviour and appropriate treatment management could explain these findings. Risk management plans should therefore be maintained. DA - 2019//10/01 PY - 2019 DO - 10.1093/ije/dyz093 DP - PubMed VL - 48 IS - 5 SP - 1623 EP - 1635 J2 - Int J Epidemiol LA - eng SN - 1464-3685 ST - Risk of suicide attempt associated with isotretinoin KW - Acne KW - case-time-control analysis KW - isotretinoin KW - standardized incidence ratio KW - suicide KW - suicide attempt ER - TY - JOUR TI - Étude de faisabilité de la mise en place d’un système de surveillance des suicides basé sur les données des instituts médico-légaux AU - Gigonzac, Virginie AU - Khireddine-Medouni, Imane AU - Chan-Chee, Chistine AU - Rey, Grégoire AU - Chérié-Challine, Laurence T2 - Bull Epidémiol Hebd DA - 2019/// PY - 2019 VL - 3-4 SP - 63 EP - 4 J2 - Bull Epidémiol Hebd Y2 - 2020/01/23/16:43:13 ER - TY - JOUR TI - Développement et application de méthodes de traitement automatique des langues sur les causes médicales de décès pour la santé publique. AU - Robert, Aude AU - Baghdadi, Yasmine AU - Zweigenbaum, Pierre AU - Morgand, Claire AU - Grouin, Cyril AU - Lavergne, Thomas AU - Névéol, Aurélie AU - Fouillet, Anne AU - Rey, G. T2 - Bull Epidémiol Hebd DA - 2019/// PY - 2019 DP - Google Scholar VL - 5 SP - 603 EP - 609 ER - TY - JOUR TI - Principales évolutions de la mortalité par cause sur la période 2000-2016 en France métropolitaine / Main trends in cause-specific mortality in Mainland France between 2000 and 2016 AU - Boulat, Thierry AU - Ghosn, Walid AU - Morgand, Claire AU - Falissard, Louis AU - Roussel, Sylvie AU - Rey, Grégoire T2 - Bull Epidémiol Hebd DA - 2019/// PY - 2019 DP - Google Scholar SP - 29 EP - 30 UR - http://beh.santepubliquefrance.fr/beh/2019/29-30/2019_29-30_1.html ER - TY - JOUR TI - Évolution de la certification électronique des décès en France de 2011 à 2018 AU - Fouillet, Anne AU - Pigeon, Dominique AU - Carton, Isabelle AU - Robert, Aude AU - Pontais, Isabelle AU - Caserio-Schönemann, Céline AU - Rey, Grégoire T2 - Bull Epidémiol Hebd DA - 2019/// PY - 2019 DP - Google Scholar SP - 29 EP - 30 ER - TY - JOUR TI - Mise en place d’un système de surveillance des suicides reposant sur les données des instituts médico-légaux : étude de faisabilité AU - Gigonzac, V. AU - Khireddine-Medouni, I. AU - Chan-Chee, C. AU - Rey, G. AU - Chérié-Challine, L. T2 - Archives des Maladies Professionnelles et de l'Environnement AB - Objectifs En 2014, près de 9000 décès par suicide ont été dénombrés en France métropolitaine. En 2006, le CépiDc-Inserm a évalué la sous-estimation des suicides à environ 9 %, celle-ci étant notamment liée à la transmission non systématique des certificats de décès après investigation médico-légale. Par ailleurs, une étude exploratoire visant à tester des sources de données existantes pour la surveillance des suicides en lien avec le travail a permis de montrer la richesse des données des instituts médico-légaux (IML). L’objectif de ce projet est d’étudier la faisabilité de développer un système de surveillance épidémiologique des suicides, notamment ceux en lien avec le travail, basé sur les données des IML, dans le cadre de l’évolution prochaine des modalités de certifications des décès. Méthodes Santé publique France (SPFrance), en collaboration avec des IML et le CépiDc, met en place une étude pilote qui sera menée auprès de 9 IML volontaires pour une durée d’un an, à partir de janvier 2018. Pour chaque cas de suicide ou de décès d’intention indéterminée, les médecins légistes transmettront à SPFrance des informations sur les caractéristiques du décès, les données sociodémographiques, les investigations médico-légales pratiquées, les éventuelles addictions et comorbidités, les caractéristiques professionnelles et l’existence de liens potentiels entre le décès et le travail. Aucun nom ni prénom de la personne décédée ne sera collecté. Résultats Le nombre attendu de décès par suicide ou d’intention indéterminée dans les 9 IML participants devrait être supérieur à 1200 cas pour une année. La faisabilité et la pertinence de développer ce système basé sur les données des IML seront évaluées. Les décès par suicide ainsi que la part et les caractéristiques des suicides en lien potentiel avec le travail seront notamment décrits. Dans un second temps, ces données seront appariées aux données de mortalité du CépiDc afin d’analyser la concordance des causes de décès rapportées dans les deux sources. Conclusions L’utilisation des données des IML pourrait permettre d’enrichir les connaissances sur les suicides notamment en lien potentiel avec le travail et ainsi mieux orienter les actions de prévention. Si cette étude se révèle faisable, il sera recommandé de développer ce système de surveillance auprès de l’ensemble des IML, à partir du volet complémentaire du certificat de décès et dans le cadre de l’évolution des modalités de certifications des décès. DA - 2018/09/01/ PY - 2018 DO - 10.1016/j.admp.2018.05.025 DP - ScienceDirect VL - 79 IS - 4 SP - 571 J2 - Archives des Maladies Professionnelles et de l'Environnement SN - 1775-8785 ST - Mise en place d’un système de surveillance des suicides reposant sur les données des instituts médico-légaux UR - http://www.sciencedirect.com/science/article/pii/S1775878518307677 Y2 - 2020/01/23/16:43:13 ER - TY - JOUR TI - Using 'amenable mortality' as indicator of healthcare effectiveness in international comparisons: results of a validation study AU - Mackenbach, Johan P AU - Hoffmann, Rasmus AU - Khoshaba, Bernadette AU - Plug, Iris AU - Rey, Grégoire AU - Westerling, Ragnar AU - Pärna, Kersti AU - Jougla, Eric AU - Alfonso, José AU - Looman, Caspar AU - McKee, Martin T2 - Journal of epidemiology and community health AB - BACKGROUND AND STUDY AIMS: There is widespread consensus on the need for better indicators of the effectiveness of healthcare. We carried out an analysis of the validity of amenable mortality as an indicator of the effectiveness of healthcare, focusing on the potential use in routine surveillance systems of between-country variations in rates of mortality. We assessed whether the introduction of specific healthcare innovations coincided with declines in mortality from potentially amenable causes in seven European countries. In this paper, we summarise the main results of this study and illustrate them for four conditions. DATA AND METHODS: We identified 14 conditions for which considerable declines in mortality have been observed and for which there is reasonable evidence in the literature of the effectiveness of healthcare interventions to lower mortality. We determined the time at which these interventions were introduced and assessed whether the innovations coincided with favourable changes in the mortality trends from these conditions, measured using Poisson linear spline regression. All the evidence was then presented to a Delphi panel. MAIN RESULTS: The timing of innovation and favourable change in mortality trends coincided for only a few conditions. Other reasons for mortality decline are likely to include diffusion and improved quality of interventions and in incidence of diseases and their risk factors, but there is insufficient evidence to differentiate these at present. For most conditions, a Delphi panel could not reach consensus on the role of current mortality levels as measures of effectiveness of healthcare. DISCUSSION AND CONCLUSIONS: Improvements in healthcare probably lowered mortality from many of the conditions that we studied but occurred in a much more diffuse way than we assumed in the study design. Quantification of the contribution of healthcare to mortality requires adequate data on timing of innovation and trends in diffusion and quality and in incidence of disease, none of which are currently available. Given these gaps in knowledge, between-country differences in levels of mortality from amenable conditions should not be used for routine surveillance of healthcare performance. The timing and pace of mortality decline from amenable conditions may provide better indicators of healthcare performance. DA - 2013/02// PY - 2013 DO - 10.1136/jech-2012-201471 DP - NCBI PubMed VL - 67 IS - 2 SP - 139 EP - 146 J2 - J Epidemiol Community Health LA - eng SN - 1470-2738 ST - Using 'amenable mortality' as indicator of healthcare effectiveness in international comparisons KW - Delivery of Health Care KW - Diffusion of Innovation KW - Europe KW - Humans KW - Mortality KW - Population Surveillance KW - Quality of Health Care KW - Regression Analysis ER - TY - JOUR TI - Incidence of gastrointestinal cancers in France AU - Bouvier, Anne-Marie AU - Remontet, Laurent AU - Jougla, Eric AU - Launoy, Guy AU - Grosclaude, Pascale AU - Buémi, Antoine AU - Tretarre, Brigitte AU - Velten, Michel AU - Dancourt, Vincent AU - Menegoz, François AU - Guizard, Anne-Valérie AU - Macé Lesec'h, Josette AU - Peng, Jung AU - Bercelli, Paolo AU - Arveux, Patrick AU - Estève, Jacques AU - Faivre, Jean T2 - Gastroentérologie clinique et biologique AB - AIM: Monitoring cancer incidence and time trends is essential for cancer research and health care planning. The aim of the study was to compare the incidence of gastrointestinal cancers in twelve administrative area in France to estimate the national cancer incidence during 2000 compared with the preceding 20 years. METHODS: Incidence data was provided by cancer registries and mortality data by the French national medical research institute (INSERM). The two data sets were modeled separately over the period 1988-1997 using age-cohort models. The incidence/mortality ratio obtained from these models was applied to the mortality rates of an age-cohort model of the entire population. RESULTS: The estimated number of new cases of gastrointestinal cancer was 61,465 in 2000. Colorectal cancer was the leading localization with 36,257 cases. The incidence of gastrointestinal cancers was slightly higher in northern than in southern area. Incidence of esophageal cancer was three times that of liver cancer. Variations in incidence were less marked for other localizations. The incidence of gastric and esophageal cancer in the male population decreased between 1980 and 2000, on average by slightly more than 2% per year. Incidence of other cancers increased. The number of new cases of colorectal cancer increased by 50%. The rise in the incidence of liver cancer was particularly striking, with an increase from 2000 incident cases in 1980 to nearly 6000 in 2000. CONCLUSION: For most localizations, incidence of gastrointestinal cancers displays few geographical differences in France, but there has been a striking change in incidence trends over the past 20 years. DA - 2004/10// PY - 2004 DP - NCBI PubMed VL - 28 IS - 10 Pt 1 SP - 877 EP - 881 J2 - Gastroenterol. Clin. Biol. LA - eng SN - 0399-8320 KW - Adolescent KW - Adult KW - Aged KW - Child KW - Child, Preschool KW - Female KW - France KW - Gastrointestinal Neoplasms KW - Geography KW - Humans KW - Incidence KW - Infant KW - Infant, Newborn KW - Male KW - Middle Aged ER - TY - JOUR TI - [Preliminary results from the SFAR-iNSERM inquiry on anaesthesia-related deaths in France: mortality rates have fallen ten-fold over the past two decades] AU - Lienhart, André AU - Auroy, Yves AU - Péquignot, Françoise AU - Benhamou, Dan AU - Warszawski, Josiane AU - Bovet, Martine AU - Jougla, Eric T2 - Bulletin de l'Académie nationale de médecine AB - A National Confidential Inquiry was conducted among death certificators and anaesthetists. A sample of 3700 death certificates from the year 1999 were randomised, after selection of words relating to anaesthesia, surgery, obstetrics, endoscopy, procedural complications, and violent death, with different ratios according to the words and the age; 500 additional certificates relating to deaths in hospital were evaluated to verify the exhaustive nature of the mention of procedures in the certificates. The certificator was sent a simplified form each time the role of the procedure in death could not be excluded (response rate 97%). The anaesthetist was offered a peer review whenever the role of the anaesthetic procedure could not be ruled out (uptake rate 97%). An expert committee analysed the (anonymized) files to determinate the mechanism of the accident and its relationship to anaesthesia. The mortality rates were estimated from the 1996 "Anaesthesia in France" survey. The annual rates of deaths that were totally or partially related to anaesthesia were respectively 7 (CI95%: 2-12) and 47 (31-63) per million. These mortality rates increased with comorbidity, from 4 per million in patients of ASA physical status class 1 to 554 per million in class 4. Similarly, these rates increased with age, from 7 per million in patients less than 45 years old, to 32 in older patients. Most accidents were of ventilatory (38%: airway management: 6%, aspiration pneumonitis: 9%), cardiac (31%: ischaemia: 25%, including anaemia-related), and vascular origin (30%: hemorrhage: 12%, vasodilation by spinal anaesthesia: 6%, anaphylaxis: 3%). The main surgical procedures involved were orthopaedic (50%: hip fracture, haemorrhagic surgery) and digestive (24%: occlusion, peritonitis). INSERM had previously collected data on complications associated with anaesthesia between 1978 and 1982: the annual rates of deaths that were totally or partially related to anaesthesia were respectively 76 and 263 per million. Compared to these previous data, the anaesthesia-related mortality rate fell ten-fold over the last two decades, while the number of anaesthetic procedures at least doubled. In addition, the number of procedures involving old people and patients with poor physical status was multiplied by four. It seems logical to attribute these results to safety and practice guidelines published after the previous inquiry. Progress remains to be made: the present rate of 1/145000 will serve as a basis for systematic analysis of accidents. DA - 2004/// PY - 2004 DP - NCBI PubMed VL - 188 IS - 8 SP - 1429 EP - 1437; discussion 1437-1441 J2 - Bull. Acad. Natl. Med. LA - fre SN - 0001-4079 ST - [Preliminary results from the SFAR-iNSERM inquiry on anaesthesia-related deaths in France KW - Aged KW - Anesthesia, General KW - Female KW - France KW - Humans KW - Male KW - Middle Aged KW - Mortality KW - Practice Guidelines as Topic KW - Safety ER - TY - JOUR TI - Opportunistic infections as causes of death in HIV-infected patients in the HAART era in France AU - Bonnet, Fabrice AU - Lewden, Charlotte AU - May, Thierry AU - Heripret, Laurence AU - Jougla, Eric AU - Bevilacqua, Sibylle AU - Costagliola, Dominique AU - Salmon, Dominique AU - Chêne, Geneviève AU - Morlat, Philippe AU - Mortalité 2000 Study Group T2 - Scandinavian journal of infectious diseases AB - The objective of the study was to describe the underlying causes of death of HIV-infected patients in the HAART era and to focus on those related to opportunistic infection (OI), in a national multicentre study ('Mortalité 2000'). A total of 964 deaths were recorded and 924 cases were available for analysis. Underlying cause of death were AIDS-related (47%), viral hepatitis (11%), non-AIDS cancers (11%), cardiovascular diseases (7%) and others (11%). Among patients who died of AIDS events, 262 (27%) died of at least one OI. OIs reported at the time of death were Cytomegalovirus infection 67 times, Pneumocystis jiroveci pneumonia 56, disseminated Mycobacterium avium intracellulare infection 53 and cerebral toxoplasmosis 48. Compared to patients who died of other causes, patients who died of OIs were younger and more likely to be infected through heterosexual contact, in poor socioeconomic conditions, migrants, more recently diagnosed for HIV infection, and naive of antiretroviral therapy and OI prophylaxis. OIs are still a major cause of death in HIV-infected patient in the HAART era, especially among patients recently diagnosed for HIV infection and who do not have access to care, as well as in long term infected patients where prophylaxis should be revisited. DA - 2005/// PY - 2005 DP - NCBI PubMed VL - 37 IS - 6-7 SP - 482 EP - 487 J2 - Scand. J. Infect. Dis. LA - eng SN - 0036-5548 KW - AIDS-Related Opportunistic Infections KW - Adult KW - Antiretroviral Therapy, Highly Active KW - Female KW - France KW - HIV Infections KW - Humans KW - Male KW - Middle Aged ER - TY - JOUR TI - Survey of anesthesia-related mortality in France AU - Lienhart, André AU - Auroy, Yves AU - Péquignot, Françoise AU - Benhamou, Dan AU - Warszawski, Josiane AU - Bovet, Martine AU - Jougla, Eric T2 - Anesthesiology AB - BACKGROUND: This study describes a nationwide survey that estimates the number and characteristics of anesthesia-related deaths for the year 1999. METHODS: Death certificates from the French national mortality database were selected from the International Classification of Diseases, Ninth Revision codes using a variable sampling fraction. Medical certifiers were sent a questionnaire (response rate, 97%), and the anesthesiologist in charge was offered a peer review (acceptance rate, 97%). Files were reviewed to determine the mechanism of each perioperative death and its relation to anesthesia. Mortality rates were calculated using the number of anesthetic procedures estimated from a national 1996 survey and compared with a previous (1978-1982) nationwide study. RESULTS: Among the 4,200 certificates analyzed, 256 led to a detailed evaluation. The death rates totally or partially related to anesthesia for 1999 were 0.69 in 100,000 (95% confidence interval, 0.22-1.2 in 100,000) and 4.7 in 100,000 (3.1-6.3 in 100,000), respectively. The death rate increased from 0.4 to 55 in 100,000 for American Society of Anesthesiologists physical status I and IV patients, respectively. Rates increased with increasing age. Although concerns regarding aspiration of gastric contents remain, intraoperative hypotension and anemia associated with postoperative ischemic complications were the associated factors most often encountered. Deviations from standard practice and organizational failure were often found to be associated with death. CONCLUSION: In comparison with data from a previous nationwide study (1978-1982), the anesthesia-related mortality rate in France seems to be reduced 10-fold in 1999. Much remains to be done to improve compliance of physicians to standard practice and to improve the anesthetic system process. DA - 2006/12// PY - 2006 DP - NCBI PubMed VL - 105 IS - 6 SP - 1087 EP - 1097 J2 - Anesthesiology LA - eng SN - 0003-3022 KW - Adolescent KW - Adult KW - Aged KW - Aged, 80 and over KW - Anesthesia KW - Child KW - Child, Preschool KW - Female KW - France KW - Health Care Surveys KW - Humans KW - Infant KW - Male KW - Middle Aged KW - Questionnaires ER - TY - JOUR TI - The impact of major heat waves on all-cause and cause-specific mortality in France from 1971 to 2003 AU - Rey, Grégoire AU - Jougla, Eric AU - Fouillet, Anne AU - Pavillon, Gérard AU - Bessemoulin, Pierre AU - Frayssinet, Philippe AU - Clavel, Jacqueline AU - Hémon, Denis T2 - International archives of occupational and environmental health AB - OBJECTIVES: The aim of the study was to identify the major heat waves (HW) that occurred in France from 1971 to 2003 and describe their impact on all-cause and cause-specific mortality. METHODS: Heat waves were defined as periods of at least three consecutive days when the maximum and the minimum temperature, averaged over the whole France, were simultaneously greater than their respective 95th percentile. The underlying causes of death were regrouped into 18 categories. Heatstroke, hyperthermia and dehydration were assigned to the "heat-related causes" (HRC) category. The numbers of deaths observed (O) during the identified HW were compared to those expected (E) on the basis of the mortality rates reported for the three preceding years. RESULTS: Six HW were identified from the period 1971 to 2003. They were associated with great excess mortality (from 1,300 to 13,700 deaths). The observations are compatible with a moderate harvesting effect for four of the six HW. The mortality ratios increased with age for subjects aged over 55 years and were higher for women than for men over 75 years. For the six HW, the excess mortality was significant for almost all the causes of death: (1) the greatest excess mortality (O-E) were observed for cardiovascular diseases, neoplasms, respiratory system diseases, HRC, ill-defined conditions and injury and poisoning, and (2) the mortality ratios (O/E) were highest for HRC, respiratory diseases, nervous system diseases, mental disorders, infectious diseases, and endocrine and nutritional diseases. CONCLUSIONS: Heat waves associated with excess mortality are not rare events in this temperate-climate country. The excess mortality is much greater than HRC mortality. Some populations are particularly vulnerable to HW: the elderly, women and people with some specific diseases. However, no segment of the population may be considered protected from the risks associated with HW. DA - 2007/07// PY - 2007 DO - 10.1007/s00420-007-0173-4 DP - NCBI PubMed VL - 80 IS - 7 SP - 615 EP - 626 J2 - Int Arch Occup Environ Health LA - eng SN - 0340-0131 KW - Adult KW - Age Factors KW - Aged KW - Female KW - France KW - Hot Temperature KW - Humans KW - Male KW - Middle Aged KW - Mortality KW - Sex Factors ER - TY - JOUR TI - Population-level influence of rheumatoid arthritis on mortality and recent trends: a multiple cause-of-death analysis in France, 1970-2002 AU - Ziadé, Nelly AU - Jougla, Eric AU - Coste, Joel T2 - The Journal of rheumatology AB - OBJECTIVE: We studied the population-level influence of rheumatoid arthritis (RA) on the mortality of the French population and the pattern of associated causes between 1970 and 2002, using death certificates. METHODS: All French death certificates (n=17,806,923) between 1970 and 2002 were analyzed. Mortality rates related to RA were studied using Poisson regression, and associated causes of death were estimated using the method of observed/expected pairs. Modifications of the International Classification of Diseases and coding methods were considered. RESULTS: RA was mentioned in 0.22% of death certificates. The age-adjusted mortality rates declined during the initial period, but increased in the early 1990s, this trend being driven by the rise in mortality in older groups. The mean age at death was lower for RA-associated deaths than for the general population. Patterns of associated causes of death were identified: there was an increase of the associations with injury, poisoning, external causes, and immunosuppressive toxicities; and a decrease of the associations with endocrine diseases, decubitus ulcers, and glucocorticoid toxicities. CONCLUSION: RA has a significant impact on mortality in the French population, with a trend toward an increase of associated mortality rates in the older population groups starting in the 1990s. DA - 2008/10// PY - 2008 DP - NCBI PubMed VL - 35 IS - 10 SP - 1950 EP - 1957 J2 - J. Rheumatol. LA - eng SN - 0315-162X ST - Population-level influence of rheumatoid arthritis on mortality and recent trends KW - Adult KW - Aged KW - Aged, 80 and over KW - Arthritis, Rheumatoid KW - Female KW - France KW - Humans KW - Male KW - Middle Aged ER - TY - JOUR TI - A deep artificial neural network based model for underlying cause of death from death certificates: Algorithm Development and Validation AU - Falissard, Louis AU - Morgand, Claire AU - Roussel, Sylvie AU - Imbaud, Claire AU - Ghosn, Walid AU - Bounebache, Karim AU - Rey, Grégoire T2 - J Med Internet Res DA - 2020/// PY - 2020 J2 - J Med Internet Res ER - TY - JOUR TI - Time trends in hospital-referred stroke and transient ischemic attack: results of a 7-year nationwide survey in France AU - Béjot, Yannick AU - Aouba, Albertine AU - de Peretti, Christine AU - Grimaud, Olivier AU - Aboa-Eboulé, Corine AU - Chin, Francis AU - Woimant, France AU - Jougla, Eric AU - Giroud, Maurice T2 - Cerebrovascular diseases (Basel, Switzerland) AB - BACKGROUND: Nationwide evaluations of the burden of stroke are scarce. We aimed to evaluate trends in stroke and transient ischemic attack (TIA) hospitalization, in-hospital case fatality rates (CFRs) and mortality rates in France during 2000-2006. METHODS: Hospitalizations for stroke and TIA were determined from National Hospital Discharge Diagnosis Records that used the International Classification of Disease, 10th revision, codes I60, I61, I63, I64, G45, G46. CFRs and mortality rates were estimated from the national death certificates database. RESULTS: The total number of stays for stroke increased between 2000 and 2006 (88,371 vs. 92,118) contrasting with a decrease in that for TIA. The age-standardized (European population) hospitalization rates for TIA decreased in men (52.2 vs. 44.5/100,000/year, p = 0.002), whereas they remained stable in women (32.4 vs. 31.0/ 100,000/year). Concerning stroke, a decrease in hospitalization rates was observed in both men (from 135.3 to 123.4/ 100,000/year, p < 0.001) and women (from 85.1 to 80.7, p < 0.001). Whatever the age group and the sex, a sharp decrease in in-hospital stroke CFRs was noted. In addition, a 23% decrease in mortality rates was observed. This decrease was greater in patients >65 years. CONCLUSION: Our results demonstrate a decline in hospitalization rates for stroke, and in both stroke CFRs and mortality rates between 2000 and 2006. Improvements in stroke prevention and acute stroke care may have contributed to these results, and may have been initiated by recent advances in health policy with regard to this disease in France. DA - 2010/// PY - 2010 DO - 10.1159/000319569 DP - NCBI PubMed VL - 30 IS - 4 SP - 346 EP - 354 J2 - Cerebrovasc. Dis. LA - eng SN - 1421-9786 ST - Time trends in hospital-referred stroke and transient ischemic attack KW - Aged KW - Aged, 80 and over KW - Female KW - France KW - Health Surveys KW - Hospitalization KW - Humans KW - Ischemic Attack, Transient KW - Length of Stay KW - Longitudinal Studies KW - Male KW - Retrospective Studies KW - Survival Rate KW - Tissue Plasminogen Activator KW - stroke ER - TY - JOUR TI - Neural translation and automated recognition of ICD10 medical entities from natural language AU - Falissard, Louis AU - Morgand, Claire AU - Roussel, Sylvie AU - Imbaud, Claire AU - Ghosn, Walid AU - Bounebache, Karim AU - Rey, Grégoire AB - The recognition of medical entities from natural language is an ubiquitous problem in the medical field, with applications ranging from medical act coding to the analysis of electronic health data for public health. It is however a complex task usually requiring human expert intervention, thus making it expansive and time consuming. The recent advances in artificial intelligence, specifically the raise of deep learning methods, has enabled computers to make efficient decisions on a number of complex problems, with the notable example of neural sequence models and their powerful applications in natural language processing. They however require a considerable amount of data to learn from, which is typically their main limiting factor. However, the CépiDc stores an exhaustive database of death certificates at the French national scale, amounting to several millions of natural language examples provided with their associated human coded medical entities available to the machine learning practitioner. This article investigates the applications of deep neural sequence models to the medical entity recognition from natural language problem. DA - 2020/03/27/ PY - 2020 DP - arxiv.org LA - en UR - https://arxiv.org/abs/2004.13839v2 Y2 - 2020/08/27/08:58:50 ER - TY - JOUR TI - A Deep Artificial Neural Network-Based Model for Prediction of Underlying Cause of Death From Death Certificates: Algorithm Development and Validation AU - Falissard, Louis AU - Morgand, Claire AU - Roussel, Sylvie AU - Imbaud, Claire AU - Ghosn, Walid AU - Bounebache, Karim AU - Rey, Grégoire T2 - JMIR medical informatics AB - BACKGROUND: Coding of underlying causes of death from death certificates is a process that is nowadays undertaken mostly by humans with potential assistance from expert systems, such as the Iris software. It is, consequently, an expensive process that can, in addition, suffer from geospatial discrepancies, thus severely impairing the comparability of death statistics at the international level. The recent advances in artificial intelligence, specifically the rise of deep learning methods, has enabled computers to make efficient decisions on a number of complex problems that were typically considered out of reach without human assistance; they require a considerable amount of data to learn from, which is typically their main limiting factor. However, the CépiDc (Centre d'épidémiologie sur les causes médicales de Décès) stores an exhaustive database of death certificates at the French national scale, amounting to several millions of training examples available for the machine learning practitioner. OBJECTIVE: This article investigates the application of deep neural network methods to coding underlying causes of death. METHODS: The investigated dataset was based on data contained from every French death certificate from 2000 to 2015, containing information such as the subject's age and gender, as well as the chain of events leading to his or her death, for a total of around 8 million observations. The task of automatically coding the subject's underlying cause of death was then formulated as a predictive modelling problem. A deep neural network-based model was then designed and fit to the dataset. Its error rate was then assessed on an exterior test dataset and compared to the current state-of-the-art (ie, the Iris software). Statistical significance of the proposed approach's superiority was assessed via bootstrap. RESULTS: The proposed approach resulted in a test accuracy of 97.8% (95% CI 97.7-97.9), which constitutes a significant improvement over the current state-of-the-art and its accuracy of 74.5% (95% CI 74.0-75.0) assessed on the same test example. Such an improvement opens up a whole field of new applications, from nosologist-level batch-automated coding to international and temporal harmonization of cause of death statistics. A typical example of such an application is demonstrated by recoding French overdose-related deaths from 2000 to 2010. CONCLUSIONS: This article shows that deep artificial neural networks are perfectly suited to the analysis of electronic health records and can learn a complex set of medical rules directly from voluminous datasets, without any explicit prior knowledge. Although not entirely free from mistakes, the derived algorithm constitutes a powerful decision-making tool that is able to handle structured medical data with an unprecedented performance. We strongly believe that the methods developed in this article are highly reusable in a variety of settings related to epidemiology, biostatistics, and the medical sciences in general. DA - 2020/04/28/ PY - 2020 DO - 10.2196/17125 DP - PubMed VL - 8 IS - 4 SP - e17125 J2 - JMIR Med Inform LA - eng SN - 2291-9694 ST - A Deep Artificial Neural Network-Based Model for Prediction of Underlying Cause of Death From Death Certificates KW - deep learning KW - machine learning KW - mortality statistics KW - underlying cause of death ER - TY - JOUR TI - Contacts with Health Services During the Year Prior to Suicide Death and Prevalent Conditions A Nationwide Study AU - Laanani, Moussa AU - Imbaud, Claire AU - Tuppin, Philippe AU - Poulalhon, Claire AU - Jollant, Fabrice AU - Coste, Joël AU - Rey, Grégoire T2 - Journal of Affective Disorders AB - BACKGROUND: This study was designed to describe contacts with health services during the year before suicide death in France, and prevalent mental and physical conditions. METHODS: Data were extracted from the French National Health Data System (SNDS), which comprises comprehensive claims data for inpatient and outpatient care linked to the national causes-of-death registry. Individuals aged ≥15 years who died from suicide in France in 2013-2015 were included. Medical consultations, emergency room visits, and hospitalisations during the year preceding death were collected. Conditions were identified, and standardised prevalence ratios (SPRs) were estimated to compare prevalence rates in suicide decedents with those of the general population. RESULTS: The study included 19,144 individuals. Overall, 8.5% of suicide decedents consulted a physician or attended an emergency room on the day of death, 34.1% during the week before death, 60.9% during the month before death. Most contacts involved a general practitioner or an emergency room. During the month preceding suicide, 24.4% of individuals were hospitalised at least once. Mental conditions (36.8% of cases) were 7.9-fold more prevalent in suicide decedents than in the general population. The highest SPRs among physical conditions were for liver/pancreatic diseases (SPR=3.3) and epilepsy (SPR=2.7). LIMITATIONS: The study population was restricted to national health insurance general scheme beneficiaries (76% of the population living in France). CONCLUSIONS: Suicide decedents have frequent contacts with general practitioners and emergency departments during the last weeks before death. Improving suicide risk identification and prevention in these somatic healthcare settings is needed. DA - 2020/09/01/ PY - 2020 DO - 10.1016/j.jad.2020.05.071 DP - PubMed VL - 274 SP - 174 EP - 182 J2 - J Affect Disord LA - eng SN - 1573-2517 KW - Health Services KW - Mental Disorders KW - Somatic Disorders KW - Suicide KW - Utilisation ER - TY - JOUR TI - National Variations in Recent Trends of Sudden Unexpected Infant Death Rate in Western Europe AU - de Visme, Sophie AU - Chalumeau, Martin AU - Levieux, Karine AU - Patural, Hugues AU - Harrewijn, Inge AU - Briand-Huchet, Elisabeth AU - Rey, Grégoire AU - Morgand, Claire AU - Blondel, Béatrice AU - Gras-Le Guen, Christèle AU - Hanf, Matthieu T2 - The Journal of Pediatrics AB - OBJECTIVE: To study recent epidemiologic trends of sudden unexpected death in infancy (SUDI) in Western Europe. STUDY DESIGN: Annual national statistics of death causes for 14 Western European countries from 2005 to 2015 were analyzed. SUDI cases were defined as infants younger than 1 year with the underlying cause of death classified as "sudden infant death syndrome," "unknown/unattended/unspecified cause," or "accidental threats to breathing." Poisson regression models were used to study temporal trends of SUDI rates and source of variation. RESULTS: From 2005 to 2015, SUDI accounted for 15 617 deaths, for an SUDI rate of 34.9 per 100 000 live births. SUDI was the second most common cause of death after the neonatal period (22.2%) except in Belgium, Finland, France, and the UK, where it ranked first. The overall SUDI rate significantly decreased from 40.2 to 29.9 per 100 000, with a significant rate reduction experienced for 6 countries, no significant evolution for 7 countries, and a significant increase for Denmark. The sudden infant death syndrome/SUDI ratio was 56.7%, with a significant decrease from 64.9% to 49.7% during the study period, and ranged from 6.1% in Portugal to 97.8% in Ireland. We observed between-country variations in SUDI and sudden infant death syndrome sex ratios. CONCLUSIONS: In studied countries, SUDI decreased during the study period but remained a major cause of infant deaths, with marked between-country variations in rates, trends, and components. Standardization is needed to allow for comparing data to improve the implementation of risk-reduction strategies. DA - 2020/06/23/ PY - 2020 DO - 10.1016/j.jpeds.2020.06.052 DP - PubMed J2 - J. Pediatr. LA - eng SN - 1097-6833 KW - Europe KW - epidemiology KW - infant mortality KW - public health KW - sudden infant death syndrome KW - sudden unexpected death in infancy KW - trends ER - TY - JOUR TI - Liver disease as a major cause of death among HIV infected patients: role of hepatitis C and B viruses and alcohol AU - Salmon-Ceron, Dominique AU - Lewden, Charlotte AU - Morlat, Philippe AU - Bévilacqua, Sibylle AU - Jougla, Eric AU - Bonnet, Fabrice AU - Héripret, Laurence AU - Costagliola, Dominique AU - May, Thierry AU - Chêne, Geneviève AU - Mortality 2000 study group T2 - Journal of hepatology AB - BACKGROUND/AIMS: We analyzed the characteristics of HIV infected patients who died from liver disease, focusing on hepatitis virus co-infection. METHODS: One-hundred and eighty-five French hospital departments involved in HIV/AIDS management prospectively notified all deaths occurring in 2000. Patients whose hepatitis C (HCV) and hepatitis B (HBV) serostatus was known were classified as being infected by HCV alone, HBV alone (HBsAg positive), both HCV and HBV, or neither HCB nor HBV. RESULTS: Among 822 HIV infected patients, 29% were infected by HCV alone, 8% by HBV alone, and 4% by both HCV and HBV. The most frequent causes of death were liver disease (31% of cases) and AIDS (29%) among HIV-HCV co-infected patients, and AIDS (38%) and liver disease (22%) among HIV-HBV co-infected patients. Liver disease was a more frequent cause of death among patients co-infected by both HCV and HBV (44% of cases). Hepatocellular carcinoma was present in 15% of patients who died from liver disease, and was associated with HBV co-infection. Nearly half the patients who died from liver disease had more than 200 CD4/mm3. CONCLUSIONS: Liver disease is now a leading cause of death among HIV-HCV co-infected patients and is becoming an important cause of death among HIV-HBV co-infected patients. The risk of death from liver disease is highest in patients co-infected by both HCV and HBV. DA - 2005/06// PY - 2005 DP - NCBI PubMed VL - 42 IS - 6 SP - 799 EP - 805 J2 - J. Hepatol. LA - eng SN - 0168-8278 ST - Liver disease as a major cause of death among HIV infected patients KW - Adult KW - Antiviral Agents KW - Comorbidity KW - Data Collection KW - Female KW - France KW - HIV Infections KW - Hepatitis B KW - Hepatitis C KW - Humans KW - Liver Diseases, Alcoholic KW - Male KW - Risk Factors KW - Seroepidemiologic Studies ER - TY - JOUR TI - How emergency departments might alert for prehospital heat-related excess mortality? AU - Claessens, Yann-Erick AU - Taupin, Pierre AU - Kierzek, Gérald AU - Pourriat, Jean-Louis AU - Baud, Michel AU - Ginsburg, Christine AU - Jais, Jean-Philippe AU - Jougla, Eric AU - Riou, Bruno AU - Dhainaut, Jean-François AU - Landais, Paul T2 - Critical care (London, England) AB - INTRODUCTION: A major issue raised by the public health consequences of a heat wave is the difficulty of detecting its direct consequences on patient outcome, particularly because of the delay in obtaining definitive mortality results. Since emergency department (ED) activity reflects the global increase of patients' health problems during this period, the profile of patients referred to EDs might be a basis to detect an excess mortality in the catchment area. Our objective was to develop a real-time surveillance model based on ED data to detect excessive heat-related mortality as early as possible. METHODS: A day-to-day composite indicator was built using simple and easily obtainable variables related to patients referred to the ED during the 2003 heat-wave period. The design involved a derivation and validation study based on a real-time surveillance system of two EDs at Cochin Hospital and Hôtel-Dieu Hospital, Paris, France. The participants were 99,976 adult patients registered from 1 May to 30 September during 2001, 2002 and 2003. Among these participants, 3,297, 3,580 and 3,851 patients were referred to the EDs from 3 August to 19 August for 2001, 2002 and 2003, respectively. Variables retained for the indicator were selected using the receiver operating characteristic curve methodology and polynomial regression. RESULTS: The indicator was composed of only three variables: the percentage of patients older than 70 years, the percentage of patients with body temperature above 39 degrees C, and the percentage of patients admitted to or who died in the ED. The curve of the indicator with time appropriately fitted the overall mortality that occurred in the region of interest. CONCLUSION: A composite and simple index based on real-time surveillance was developed according to the profile of patients who visited the ED. It appeared suitable for determining the overall mortality in the corresponding region submitted to the 2003 heat wave. This index should help early warning of excessive mortality and monitoring the efficacy of public health interventions. DA - 2006/// PY - 2006 DO - 10.1186/cc5092 DP - NCBI PubMed VL - 10 IS - 6 SP - R156 J2 - Crit Care LA - eng SN - 1466-609X KW - Adult KW - Age Factors KW - Body Temperature KW - Climate KW - Emergency Service, Hospital KW - Female KW - Hospital Mortality KW - Hot Temperature KW - Humans KW - Male KW - Middle Aged KW - Population Surveillance KW - Public health KW - Risk Assessment ER - TY - JOUR TI - Stroke and vascular mortality trends in France: 1979-2001 AU - Lavallée, Philippa C AU - Labreuche, Julien AU - Spieler, Jean-François AU - Jougla, Eric AU - Amarenco, Pierre T2 - Neuroepidemiology AB - BACKGROUND: The therapeutic armamentarium for vascular risk factors in industrialized countries improved over the past decades. We therefore studied vascular mortality trends in France between 1979 and 2001, and explored how these trends are related to stroke or nonstroke vascular mortality changes. MATERIALS AND METHODS: We included all deaths from vascular disease in the French population from 1979 to 2001. Trends for total, stroke and nonstroke vascular mortality were estimated using log-linear Poisson regression models. Gender-specific mortality rates were standardized directly by 5-year groups to the 1990 French population. RESULTS: During the 1979-2001 period, the mean annual percentage change in vascular death rates varied across age groups (or=75) between -2.4 to -3.3% in men and -2.5 to -4.1% in women. Respectively, 25.7 and 30.9% of total vascular death was attributed to cerebrovascular disease in men and women. Stroke mortality and nonstroke vascular mortality rates declined respectively by 60.9 and 34.6% in men, and 60.4 and 38.9% in women. CONCLUSION: We observed a dramatic 60% reduction of stroke death in France in the last 20 years. Stroke death decreased at about twice the rate as other causes of vascular death. Improved management of vascular risk factors could partly explain these results. DA - 2007/// PY - 2007 DO - 10.1159/000109500 DP - NCBI PubMed VL - 29 IS - 1-2 SP - 78 EP - 82 J2 - Neuroepidemiology LA - eng SN - 1423-0208 ST - Stroke and vascular mortality trends in France KW - Adult KW - Age Distribution KW - Aged KW - Female KW - France KW - Humans KW - Male KW - Middle Aged KW - Mortality KW - Poisson Distribution KW - Risk Factors KW - Sex Distribution KW - Vascular Diseases KW - stroke ER - TY - JOUR TI - The burden of diabetes-related mortality in France in 2002: an analysis using both underlying and multiple causes of death AU - Romon, Isabelle AU - Jougla, Eric AU - Balkau, Beverley AU - Fagot-Campagna, Anne T2 - European journal of epidemiology AB - AIM: To describe the burden of diabetes-related mortality in France. METHODS: Underlying and multiple causes (all causes listed) of death were extracted from the 2002 French national mortality registry. Death rates were standardized on the age structure of the European population. RESULTS: Diabetes was reported as the underlying cause of death in 11,177 certificates (2.1%), and as multiple causes in 29,357 certificates (5.3%), giving a ratio (multiple/underlying causes) of 2.6. When diabetes was a multiple cause, the mean age at death was 75 years in men, 81 years in women. The age-standardized mortality rates were 41.0/100,000 in men, 24.6/100,000 in women. The excess mortality observed in men (men/women ratio = 1.7) decreased with age. Geographic differences were observed: higher rates in the North-East, lower rates in the West of the country. In certificates mentioning diabetes, the most frequent cause of death was diseases of the circulatory system (76%). Coronary heart diseases, foot ulcers and renal diseases were more likely to be mentioned in certificates referring to diabetes than in those that did not. DISCUSSION: The use of multiple rather than underlying causes of death more than doubled diabetes-related mortality rates. While probably still under-estimated, the burden of diabetes-related mortality corresponds to a high proportion of the total mortality, especially in men. Geographic differences partially reflect disparities in diabetes prevalence. Causes more frequently associated with diabetes include coronary heart disease and complications related to neuropathy and nephropathy. DA - 2008/// PY - 2008 DO - 10.1007/s10654-008-9235-5 DP - NCBI PubMed VL - 23 IS - 5 SP - 327 EP - 334 J2 - Eur. J. Epidemiol. LA - eng SN - 0393-2990 ST - The burden of diabetes-related mortality in France in 2002 KW - Adult KW - Age Factors KW - Aged KW - Aged, 80 and over KW - Cardiovascular Diseases KW - Comorbidity KW - Confidence Intervals KW - Diabetes Complications KW - Diabetes Mellitus KW - Female KW - France KW - Humans KW - Male KW - Middle Aged KW - Prevalence KW - Registries KW - Sex Factors ER - TY - JOUR TI - Changes in causes of death among adults infected by HIV between 2000 and 2005: The "Mortalité 2000 and 2005" surveys (ANRS EN19 and Mortavic) AU - Lewden, Charlotte AU - May, Thierry AU - Rosenthal, Eric AU - Burty, Christine AU - Bonnet, Fabrice AU - Costagliola, Dominique AU - Jougla, Eric AU - Semaille, Caroline AU - Morlat, Philippe AU - Salmon, Dominique AU - Cacoub, Patrice AU - Chêne, Geneviève AU - ANRS EN19 Mortalité Study Group and Mortavic1 T2 - Journal of acquired immune deficiency syndromes (1999) AB - BACKGROUND: The multicenter national Mortalité 2005 survey aimed at describing the distribution of causes of death among HIV-infected adults in France in 2005 and its changes as compared with 2000. METHODS: Physicians involved in the management of HIV infection notified deaths and documented the causes using a standardized questionnaire similar to the previous survey performed in 2000. RESULTS: Overall, 1042 deaths were notified in 2005 (vs 964 in 2000): with median age, 46 years (vs 41 years); men, 76%; and median last CD4 cell count, 161/mm (vs 94). The proportion of underlying causes of death due to AIDS decreased (36% in 2005 vs 47% in 2000), and the proportion of cancer not related to AIDS or hepatitis (17% vs 11%), liver related disease (15% vs 13%: hepatitis C, 11%, and hepatitis B, 2%), cardiovascular disease (8% vs 7%), or suicide (5% vs 4%) increased. Among the 375 AIDS-related deaths, the most frequent event was non-Hodgkin lymphoma (28%). Among cancers not related to AIDS or hepatitis, the most frequent localizations were lung (31%) and digestive tract (14%). Among the 154 liver-related deaths, 24% were due to hepatocarcinoma. CONCLUSIONS: The heterogeneity of causes of death among HIV-infected adults was confirmed and intensified in 2005, with 3 causes following AIDS: cancers and liver-related and cardiovascular diseases. DA - 2008/08/15/ PY - 2008 DO - 10.1097/QAI.0b013e31817efb54 DP - NCBI PubMed VL - 48 IS - 5 SP - 590 EP - 598 J2 - J. Acquir. Immune Defic. Syndr. LA - eng SN - 1525-4135 ST - Changes in causes of death among adults infected by HIV between 2000 and 2005 KW - Acquired Immunodeficiency Syndrome KW - Adult KW - Cardiovascular Diseases KW - Female KW - Humans KW - Liver Diseases KW - Male KW - Middle Aged KW - Neoplasms KW - Questionnaires ER - TY - JOUR TI - How does loss to follow-up influence cohort findings on HIV infection? A joint analysis of the French hospital database on HIV, Mortalité 2000 survey and death certificates AU - Lanoy, E AU - Lewden, C AU - Lièvre, L AU - Tattevin, P AU - Boileau, J AU - Aouba, A AU - Chêne, G AU - Costagliola, D AU - Clinical Epidemiologic Group of the French Hospital Database on HIV (ANRS CO4 FHDH) AU - Groupe d'Etude Mortalité 2000 T2 - HIV medicine AB - OBJECTIVE: We aimed to retrieve the vital status of patients lost to follow-up (LFU), with no further visits for at least 12 months, for the 34,835 patients in the Agence Nationale de Recherche sur le SIDA CO4 French Hospital Database on HIV (ANRS CO4 FHDH) seen in 1999 and to examine how loss to follow-up might influence estimates of survival and the impact of delayed access to care (DAC) on survival. METHODS: The status of LFU patients was established by using the mid-2006 update of the FHDH in which their status 12 months after loss to follow-up was added when available and by matching with the Mortalité 2000-Epidemiological Centre for Medical Causes of Death (CépiDc) database, which included HIV-infected patients dying in 2000. We compared Kaplan-Meier and hazard ratio (HR) estimates before and after correction for the status of LFU patients. RESULTS: In the mid-2006 updated FHDH, of the patients seen in 1999, 7.5% were LFU: of these, 2.1% later returned for follow-up, with a median time without follow-up in an FHDH centre of 3.5 years, and 5.4% had no further FHDH visits whatsoever, of whom 29.8% died according to Mortalité 2000-CépiDc. After correction, the estimated 1-year survival rates following enrolment in 1999 differed between the original and updated analyses (97.1 vs. 95.9%, respectively; P=0.017); the estimates of mortality HRs associated with DAC did not differ during the first 6 months, but did differ for the 6-18-month period. CONCLUSIONS: Among LFU patients, 28.1% returned to follow-up after several years and at least 21.4% died, which led to a slight overestimation of both survival and the impact of DAC on survival. DA - 2009/04// PY - 2009 DO - 10.1111/j.1468-1293.2008.00678.x DP - NCBI PubMed VL - 10 IS - 4 SP - 236 EP - 245 J2 - HIV Med. LA - eng SN - 1468-1293 ST - How does loss to follow-up influence cohort findings on HIV infection? KW - Adult KW - Africa South of the Sahara KW - Bias (Epidemiology) KW - Cohort Studies KW - Female KW - France KW - French Guiana KW - HIV Infections KW - Health Services Accessibility KW - Hospitals KW - Humans KW - Kaplan-Meier Estimate KW - Male KW - Patient Dropouts KW - Pregnancy KW - Pregnancy Complications, Infectious KW - Proportional Hazards Models KW - West Indies ER - TY - JOUR TI - Heat exposure and socio-economic vulnerability as synergistic factors in heat-wave-related mortality AU - Rey, Grégoire AU - Fouillet, Anne AU - Bessemoulin, Pierre AU - Frayssinet, Philippe AU - Dufour, Anne AU - Jougla, Eric AU - Hémon, Denis T2 - European journal of epidemiology AB - Heat waves may become a serious threat to the health and safety of people who currently live in temperate climates. It was therefore of interest to investigate whether more deprived populations are more vulnerable to heat waves. In order to address the question on a fine geographical scale, the spatial heterogeneity of the excess mortality in France associated with the European heat wave of August 2003 was analysed. A deprivation index and a heat exposure index were used jointly to describe the heterogeneity on the Canton scale (3,706 spatial units). During the heat wave period, the heat exposure index explained 68% of the extra-Poisson spatial variability of the heat wave mortality ratios. The heat exposure index was greater in the most urbanized areas. For the three upper quintiles of heat exposure in the densely populated Paris area, excess mortality rates were twofold higher in the most deprived Cantons (about 20 excess deaths/100,000 people/day) than in the least deprived Cantons (about 10 excess deaths/100,000 people/day). No such interaction was observed for the rest of France, which was less exposed to heat and less heterogeneous in terms of deprivation. Although a marked increase in mortality was associated with heat wave exposure for all degrees of deprivation, deprivation appears to be a vulnerability factor with respect to heat-wave-associated mortality. DA - 2009/// PY - 2009 DO - 10.1007/s10654-009-9374-3 DP - NCBI PubMed VL - 24 IS - 9 SP - 495 EP - 502 J2 - Eur. J. Epidemiol. LA - eng SN - 1573-7284 KW - Aged KW - France KW - Health Status Disparities KW - Heat Stress Disorders KW - Hot Temperature KW - Humans KW - Middle Aged KW - Poisson Distribution KW - Seasons KW - Socioeconomic Factors KW - Urban Population KW - Vulnerable Populations KW - demography ER - TY - JOUR TI - Using vital statistics to estimate the population-level impact of osteoporotic fractures on mortality based on death certificates, with an application to France (2000-2004) AU - Ziadé, Nelly AU - Jougla, Eric AU - Coste, Joël T2 - BMC public health AB - BACKGROUND: We developed a methodology using vital statistics to estimate the impact of osteoporotic fractures on the mortality of an entire population, and applied it to France for the period 2000-2004. METHODS: Current definitions of osteoporotic fractures were reviewed and their components identified. We used the International Classification of Diseases with national vital statistics data for the French adult population and performed cross-classifications between various components: age, sex, I-code (site) and E-code (mechanism of fracture). This methodology allowed identification of appropriate thresholds and categorization for each pertinent component. RESULTS: 2,625,743 death certificates were analyzed, 2.2% of which carried a mention of fracture. Hip fractures represented 55% of all deaths from fracture. Both sexes showed a similar pattern of mortality rates for all fracture sites, the rate increased with age from the age of 70 years. The E-high-energy code (present in 12% of death certificates with fractures) was found to be useful to rule-out non-osteoporotic fractures, and to correct the overestimation of mortality rates. Using this methodology, the crude number of deaths associated with fractures was estimated to be 57,753 and the number associated with osteoporotic fractures 46,849 (1.85% and 1.78% of all deaths, respectively). CONCLUSION: Osteoporotic fractures have a significant impact on overall population mortality. DA - 2009/// PY - 2009 DO - 10.1186/1471-2458-9-344 DP - NCBI PubMed VL - 9 SP - 344 J2 - BMC Public Health LA - eng SN - 1471-2458 KW - Adult KW - Aged KW - Aged, 80 and over KW - Female KW - Fractures, Bone KW - France KW - Humans KW - Male KW - Middle Aged KW - Population Surveillance ER - TY - JOUR TI - PRINCIPALES ÉVOLUTIONS DE LA MORTALITÉ PAR CAUSE MÉDICALE SUR LA PÉRIODE 2000-2016 EN FRANCE MÉTROPOLITAINE / MAIN TRENDS IN CAUSE-SPECIFIC MORTALITY IN MAINLAND FRANCE BETWEEN 2000 AND 2016 AU - Boulat, Thierry DP - Zotero SP - 9 LA - fr ER - TY - JOUR TI - Causes of death among human immunodeficiency virus (HIV)-infected adults in the era of potent antiretroviral therapy: emerging role of hepatitis and cancers, persistent role of AIDS AU - Lewden, Charlotte AU - Salmon, Dominique AU - Morlat, Philippe AU - Bévilacqua, Sibylle AU - Jougla, Eric AU - Bonnet, Fabrice AU - Héripret, Laurence AU - Costagliola, Dominique AU - May, Thierry AU - Chêne, Geneviève AU - Mortality 2000 study group T2 - International journal of epidemiology AB - BACKGROUND: In the era of highly active antiretroviral therapy (HAART) mortality has decreased substantially among human immunodeficiency virus (HIV)-infected people with access to HAART, but there are concerns regarding co-morbidities and adverse effects of HAART, which may impair vital prognosis. The Mortality 2000 study examined the causes of death in HIV-infected adults at a national level in France in the year 2000. METHODS: All French hospital wards known to be involved in the management of HIV infection were asked to notify prospectively the deaths that occurred in 2000 among HIV-infected adults. The causes of death were documented using a standardized questionnaire. RESULTS: The 185 participating wards notified 964 deaths. The main underlying causes of death were AIDS-related (47%, non-Hodgkin's lymphoma: 23%), viral hepatitis (11%, hepatitis C: 9%, hepatitis B: 2%), cancer not related to AIDS or hepatitis (11%), cardiovascular disease (7%), bacterial infections (6%), suicide (4%), and adverse effect of antiretroviral treatments (1%). Among AIDS-related deaths, HIV infection had been diagnosed recently in 20%. Smoking was recorded in 72% of cancer-related deaths and alcohol consumption in 54% of hepatitis-related deaths. Among non-HIV related deaths between 25 and 64 years, the proportion of infectious diseases (including HCV and HBV-related deaths) was higher in HIV-infected adults than in the general population. CONCLUSIONS: Improved strategies for detecting HIV infection before AIDS-defining complications occur are needed in the era of HAART. The prevention of non-AIDS related cancers, especially lung cancer, the management of non-Hodgkin's lymphoma, and of viral hepatitis are also important priorities. DA - 2005/02// PY - 2005 DO - 10.1093/ije/dyh307 DP - NCBI PubMed VL - 34 IS - 1 SP - 121 EP - 130 J2 - Int J Epidemiol LA - eng SN - 0300-5771 ST - Causes of death among human immunodeficiency virus (HIV)-infected adults in the era of potent antiretroviral therapy KW - Acquired Immunodeficiency Syndrome KW - Adult KW - Age Factors KW - Aged KW - Antiretroviral Therapy, Highly Active KW - CD4 Lymphocyte Count KW - Comorbidity KW - Female KW - France KW - HIV Infections KW - Health Surveys KW - Hepatitis, Viral, Human KW - Humans KW - Male KW - Middle Aged KW - Neoplasms ER - TY - JOUR TI - [Socio-economic differences in mortality] AU - Jougla, Eric AU - Rican, Stéphane AU - Péquignot, Françoise AU - Le Toullec, Alain T2 - La Revue du praticien AB - The ranking and frequency of the different causes of death vary according to social categories. The largest disparities in mortality are observed, at first for causes linked to alcohol consumption; then for diabetes, respiratory diseases, lung cancer, cerebrovascular diseases, stomach cancer, suicide, accidents, myocardial infarction, intestine and pancreas cancer. For most of the causes of death, there is an increase in time trends in the level of the over-mortality of the group "manual workers-clerical" in comparison with the group "high level professional workers". European comparisons outlined that France and Finland have the more marked social differences in mortality. For France, this trend concerns all the causes of death apart from cardiovascular diseases and violent deaths. The role of excessive alcohol consumption is outlined as an explanation of this specific position of France. DA - 2004/12/31/ PY - 2004 DP - NCBI PubMed VL - 54 IS - 20 SP - 2228 EP - 2232 J2 - Rev Prat LA - fre SN - 0035-2640 KW - Adult KW - Age Factors KW - Alcoholism KW - Europe KW - Female KW - Finland KW - France KW - Humans KW - Male KW - Middle Aged KW - Mortality KW - Occupations KW - Risk Factors KW - Sex Factors KW - Socioeconomic Factors ER - TY - JOUR TI - TIME TREND IN EXCESS MORTALITY IN CHILDREN WITH TYPE 1 DIABETES FROM 1987 TO 2016 IN MAINLAND FRANCE AU - Donzeau, Aurelie AU - Piffaretti, Clara AU - Jossens, Anne AU - Levaillant, Lucie AU - Bouhours-Nouet, Natacha AU - Amsellem-Jager, Jessica AU - Ghosn, Walid AU - Rey, Grégoire AU - Fosse-Edorh, Sandrine AU - Coutant, Régis T2 - Pediatric Diabetes AB - BACKGROUND: Mortality risk for children with type 1 diabetes (T1D) is unknown in France and their causes of death are not well documented. AIM: To determine the Standardized Mortality ratios (SMRs) and causes of death in children aged 1 to 14 years with T1D from 1987 to 2016. METHODS: The French Center for Epidemiology on Medical Causes of Death collected all death certificates in mainland France. SMRs, corrected SMRs (accounting for missing cases of deaths unrelated to diabetes), and 95% confidence intervals were calculated. RESULTS: Of 146 deaths with the contribution of diabetes, 97 were due to T1D. Mean age at death of the subjects with T1D was 8.8 ± 4.1 years (54% males). The cause of death was diabetic ketoacidosis (DKA) in 58% of the cases (70% in subjects 1-4 years), hypoglycemia or dead-in-bed syndrome in 4%, related to diabetes but not described in 24%, and unrelated to diabetes in 14%. The SMRs showed a significant decrease across the years, except for the 1-4 age group. In the last decade (2007-2016), the crude and corrected SMRs were significantly different from 1 in the 1-4 age group (5.4 (2.3; 10.7) and 6.1 (2.8; 11.5)), no longer significant in the 5-9 age group (1.7 (0.6; 4.0) and 2.1 (0.8; 4.5) and borderline significant in the 10-14 age group (1.7 (0.8; 3.2) and 2.3 (1.2; 4.0)). CONCLUSIONS: Children with T1D aged 1-4 years still had a high mortality rate. Their needs for early recognition and safe management of diabetes are not being met. This article is protected by copyright. All rights reserved. DA - 2021/12/08/ PY - 2021 DO - 10.1111/pedi.13298 DP - PubMed J2 - Pediatr Diabetes LA - eng SN - 1399-5448 KW - children KW - death KW - diabetes KW - diabetic ketoacidosis ER - TY - JOUR TI - Association of daily temperature with suicide mortality: a comparison with other causes of death and characterization of possible attenuation across 5 decades AU - Lehmann, Fanny AU - Alary, Pierre-Etienne AU - Rey, Grégoire AU - Slama, Rémy T2 - American journal of epidemiology DA - 2022/// PY - 2022 DP - Google Scholar ST - Association of daily temperature with suicide mortality ER - TY - JOUR TI - Neural Translation and Automated Recognition of ICD-10 Medical Entities From Natural Language: Model Development and Performance Assessment AU - Falissard, Louis AU - Morgand, Claire AU - Ghosn, Walid AU - Imbaud, Claire AU - Bounebache, Karim AU - Rey, Grégoire T2 - JMIR medical informatics DA - 2022/// PY - 2022 DP - Google Scholar VL - 10 IS - 4 SP - e26353 ST - Neural Translation and Automated Recognition of ICD-10 Medical Entities From Natural Language ER - TY - JOUR TI - Recent historic increase of infant mortality in France: A time-series analysis, 2001 to 2019 AU - Trinh, Nhung TH AU - de Visme, Sophie AU - Cohen, Jérémie F. AU - Bruckner, Tim AU - Lelong, Nathalie AU - Adnot, Pauline AU - Rozé, Jean-Christophe AU - Blondel, Béatrice AU - Goffinet, François AU - Rey, Grégoire T2 - The Lancet Regional Health-Europe DA - 2022/// PY - 2022 DP - Google Scholar VL - 16 SP - 100339 ST - Recent historic increase of infant mortality in France ER - TY - JOUR TI - Time trend in excess mortality in children with type 1 diabetes from 1987 to 2016 in mainland France AU - Donzeau, Aurelie AU - Piffaretti, Clara AU - Jossens, Anne AU - Levaillant, Lucie AU - Bouhours-Nouet, Natacha AU - Amsellem-Jager, Jessica AU - Ghosn, Walid AU - Rey, Grégoire AU - Fosse-Edorh, Sandrine AU - Coutant, Régis T2 - Pediatric diabetes DA - 2022/// PY - 2022 DP - Google Scholar VL - 23 IS - 1 SP - 38 EP - 44 ER - TY - JOUR TI - HIV-specific regulatory T cells are associated with higher CD4 cell counts in primary infection AU - Kared, Hassen AU - Lelièvre, Jean-Daniel AU - Donkova-Petrini, Vladimira AU - Aouba, Albertine AU - Melica, Giovanna AU - Balbo, Michèle AU - Weiss, Laurence AU - Lévy, Yves T2 - AIDS (London, England) AB - OBJECTIVE: Expansion of regulatory T (Treg) cells has been described in chronically HIV-infected individuals. We investigated whether HIV-suppressive Treg could be detected during primary HIV infection (PHI). METHODS: Seventeen patients diagnosed early after PHI (median: 13 days; 1-55) were studied. Median CD4 cell count was 480 cells/microl (33-1306) and plasma HIV RNA levels ranged between 3.3 and 5.7 log10 copies/ml. Suppressive capacity of blood purified CD4CD25 was evaluated in a coculture assay. Fox-p3, IL-2 and IL-10 were quantified by reverse transcriptase (RT)-PCR and intracellular staining of ex vivo and activated CD4+CD25 T cells. RESULTS: The frequency of CD4CD127CD25 T cells among CD4 T cells was lower in patients with PHI compared with chronic patients (n = 19). They exhibited a phenotype of memory T cells and expressed constitutively FoxP3. Similar to chronic patients, Treg from patients with PHI inhibited the proliferation of purified tuberculin (PPD) and HIV p24 activated CD4CD25 T cells. CD4CD25 T cells from patients with PHI responded specifically to p24 stimulation by expressing IL-10. In untreated patients with PHI, the frequency as well as HIV-specific activity of Treg decreased during a 24-month follow-up. A positive correlation between percentages of Treg and both CD4 cell counts and the magnitude of p24-specific suppressive activity at diagnosis of PHI was found. CONCLUSION: Our data showed that HIV drives Treg, as PHI and these cells persist throughout the course of the infection. A correlation between the frequency of Treg and CD4 T-cell counts suggest that these cells may impact on the immune activation set point at PHI diagnosis. DA - 2008/11/30/ PY - 2008 DO - 10.1097/QAD.0b013e328319edc0 DP - NCBI PubMed VL - 22 IS - 18 SP - 2451 EP - 2460 J2 - AIDS LA - eng SN - 1473-5571 KW - CD4 Lymphocyte Count KW - Cell Proliferation KW - Female KW - Flow Cytometry KW - HIV Infections KW - HIV-1 KW - Humans KW - Interleukin-10 KW - Interleukin-2 Receptor alpha Subunit KW - Male KW - Phenotype KW - Prospective Studies KW - RNA, Viral KW - Suppressor Factors, Immunologic KW - T-Lymphocytes, Regulatory KW - Viral Load ER - TY - JOUR TI - Possible effect of environmental exposure to asbestos on geographical variation in mesothelioma rates AU - Goldberg, Stephen AU - Rey, Grégoire AU - Luce, Danièle AU - Gilg Soit Ilg, Anabelle AU - Rolland, Patrick AU - Brochard, Patrick AU - Imbernon, Ellen AU - Goldberg, Marcel T2 - Occupational and environmental medicine AB - BACKGROUND: In population-based mesothelioma studies in industrialised countries, the incidence of mesothelioma without any identified asbestos exposure (IAE) is usually higher among women, while male incidence is mainly attributed to IAE. Through a comparison of the spatial distribution of male and female rates, and IAE and no IAE incidence, this study investigated whether mesotheliomas without IAE are in fact induced by non-recognised asbestos exposure, mostly from environmental sources. METHODS: We calculated mesothelioma mortality (SMR) and incidence (SIR) ratios by district in France, pooling 30 and 10 years of data, respectively. Using correlation coefficients, we compared geographical patterns of male and female mesothelioma ratios, and IAE and no IAE mesothelioma ratios. RESULTS: The raw numbers of male and female mesothelioma cases were equivalent. Mesothelioma SMR (0.76) and SIR (0.80) geographical correlations between men and women were strongly positive. SIR correlation between occupationally IAE and no IAE cases was also positive (0.69). Correlation between occupationally IAE and no IAE cases was positive among women but not among men. CONCLUSIONS: Data analyses of mesothelioma mortality and incidence showed that female cases occur in the same geographical areas as male cases. Female mesotheliomas with no IAE occur in the same geographical areas as exposed cases, suggesting asbestos has a major influence on female mesothelioma, likely through environmental exposure. DA - 2010/06// PY - 2010 DO - 10.1136/oem.2009.050336 DP - NCBI PubMed VL - 67 IS - 6 SP - 417 EP - 421 J2 - Occup Environ Med LA - eng SN - 1470-7926 KW - Asbestos KW - Environmental Exposure KW - Female KW - France KW - Humans KW - Incidence KW - Male KW - Mesothelioma KW - Pleural Neoplasms KW - Sex Distribution ER - TY - JOUR TI - Mortality burden of the 2009 A/H1N1 influenza pandemic in France: comparison to seasonal influenza and the A/H3N2 pandemic AU - Lemaitre, Magali AU - Carrat, Fabrice AU - Rey, Grégoire AU - Miller, Mark AU - Simonsen, Lone AU - Viboud, Cécile T2 - PloS one AB - BACKGROUND: The mortality burden of the 2009 A/H1N1 pandemic remains unclear in many countries due to delays in reporting of death statistics. We estimate the age- and cause-specific excess mortality impact of the pandemic in France, relative to that of other countries and past epidemic and pandemic seasons. METHODS: We applied Serfling and Poisson excess mortality approaches to model weekly age- and cause-specific mortality rates from June 1969 through May 2010 in France. Indicators of influenza activity, time trends, and seasonal terms were included in the models. We also reviewed the literature for country-specific estimates of 2009 pandemic excess mortality rates to characterize geographical differences in the burden of this pandemic. RESULTS: The 2009 A/H1N1 pandemic was associated with 1.0 (95% Confidence Intervals (CI) 0.2-1.9) excess respiratory deaths per 100,000 population in France, compared to rates per 100,000 of 44 (95% CI 43-45) for the A/H3N2 pandemic and 2.9 (95% CI 2.3-3.7) for average inter-pandemic seasons. The 2009 A/H1N1 pandemic had a 10.6-fold higher impact than inter-pandemic seasons in people aged 5-24 years and 3.8-fold lower impact among people over 65 years. CONCLUSIONS: The 2009 pandemic in France had low mortality impact in most age groups, relative to past influenza seasons, except in school-age children and young adults. The historical A/H3N2 pandemic was associated with much larger mortality impact than the 2009 pandemic, across all age groups and outcomes. Our 2009 pandemic excess mortality estimates for France fall within the range of previous estimates for high-income regions. Based on the analysis of several mortality outcomes and comparison with laboratory-confirmed 2009/H1N1 deaths, we conclude that cardio-respiratory and all-cause mortality lack precision to accurately measure the impact of this pandemic in high-income settings and that use of more specific mortality outcomes is important to obtain reliable age-specific estimates. DA - 2012/// PY - 2012 DO - 10.1371/journal.pone.0045051 DP - NCBI PubMed VL - 7 IS - 9 SP - e45051 J2 - PLoS ONE LA - eng SN - 1932-6203 ST - Mortality burden of the 2009 A/H1N1 influenza pandemic in France KW - Adolescent KW - Adult KW - Age Distribution KW - Aged KW - Child KW - Child, Preschool KW - Cost of Illness KW - France KW - Humans KW - Infant KW - Infant, Newborn KW - Influenza A Virus, H1N1 Subtype KW - Influenza A Virus, H3N2 Subtype KW - Influenza, Human KW - Middle Aged KW - Models, Biological KW - Pandemics KW - Respiration KW - Seasons KW - Young Adult ER - TY - JOUR TI - Alcohol-attributable cancer deaths and years of potential life lost in the United States AU - Nelson, David E AU - Jarman, Dwayne W AU - Rehm, Jürgen AU - Greenfield, Thomas K AU - Rey, Grégoire AU - Kerr, William C AU - Miller, Paige AU - Shield, Kevin D AU - Ye, Yu AU - Naimi, Timothy S T2 - American journal of public health AB - OBJECTIVES: Our goal was to provide current estimates of alcohol-attributable cancer mortality and years of potential life lost (YPLL) in the United States. METHODS: We used 2 methods to calculate population-attributable fractions. We based relative risks on meta-analyses published since 2000, and adult alcohol consumption on data from the 2009 Alcohol Epidemiologic Data System, 2009 Behavioral Risk Factor Surveillance System, and 2009-2010 National Alcohol Survey. RESULTS: Alcohol consumption resulted in an estimated 18,200 to 21,300 cancer deaths, or 3.2% to 3.7% of all US cancer deaths. The majority of alcohol-attributable female cancer deaths were from breast cancer (56% to 66%), whereas upper airway and esophageal cancer deaths were more common among men (53% to 71%). Alcohol-attributable cancers resulted in 17.0 to 19.1 YPLL for each death. Daily consumption of up to 20 grams of alcohol (≤ 1.5 drinks) accounted for 26% to 35% of alcohol-attributable cancer deaths. CONCLUSIONS: Alcohol remains a major contributor to cancer mortality and YPLL. Higher consumption increases risk but there is no safe threshold for alcohol and cancer risk. Reducing alcohol consumption is an important and underemphasized cancer prevention strategy. DA - 2013/04// PY - 2013 DO - 10.2105/AJPH.2012.301199 DP - NCBI PubMed VL - 103 IS - 4 SP - 641 EP - 648 J2 - Am J Public Health LA - eng SN - 1541-0048 KW - Adult KW - Alcohol Drinking KW - Breast Neoplasms KW - Esophageal Neoplasms KW - Female KW - Humans KW - Male KW - Neoplasms KW - Population Surveillance KW - Risk Factors KW - Sex Factors KW - United States ER - TY - JOUR TI - [Causes of death in HIV-infected French drug users, 1995-2000] AU - Lewden, Charlotte AU - Bonnet, Fabrice AU - Bevilacqua, Sibylle AU - Heripret, Laurence AU - May, Thierry AU - Morlat, Philippe AU - Jougla, Eric AU - Dabis, François AU - Chêne, Geneviève AU - Salmon, Dominique AU - Groupe d'Epidémiologie Clinique du SIDA en Aquitaine AU - Groupe "Mortalité 2000" T2 - Annales de médecine interne AB - Since the decline in mortality among HIV-infected persons after introduction of highly active antiretroviral therapy, concerns related to co-morbidities have increased as they may impair vital prognosis, particularly in intravenous (IV) drug users. We describe firstly the changes in the distribution of the causes of death between 1995 and 2000 among IV drug users in the "Aquitaine Cohort" based on hospital information system, and secondly the distribution of the causes of death among IV drug users in the French national survey "Mortalité 2000" specifically set up in 2000 for optimal exhaustiveness. The total number of deaths declined between 1995 and 2000 and 1/3 were IV drug users. Deceased IV drug users were younger than other deceased patients, had longer median time from diagnosis of HIV infection and higher median CD4 cell count. Poor socio-economic conditions were notified in 55%. Among IV drug users, the proportion of AIDS-related deaths was above 75% in 1995 and below 30% in 2000. In 2000, 25% of deaths were HCV-related, 12% of deaths were due to accident, overdose or suicide, and 8% were due to non-AIDS non-HCV related cancer. Among IV drug users, improvement in vital prognosis requires to improve management of HCV infection and to take into account socio-economic conditions and other addictive behaviours like alcohol consumption and smoking. DA - 2002/11// PY - 2002 DP - NCBI PubMed VL - 153 IS - 7 Suppl SP - 2S4 EP - 10 J2 - Ann Med Interne (Paris) LA - fre SN - 0003-410X KW - Adult KW - Cohort Studies KW - Female KW - France KW - HIV Infections KW - Humans KW - Male KW - Middle Aged KW - Substance-Related Disorders ER - TY - JOUR TI - Impact of the COVID-19 crisis on the mortality profiles of the foreign-born in France during the first pandemic wave AU - Khlat, Myriam AU - Ghosn, Walid AU - Guillot, Michel AU - Vandentorren, Stéphanie AU - DcCOVMIG Research Team T2 - Social Science & Medicine (1982) AB - BACKGROUND: Immigrants in Western countries have been particularly affected by the COVID-19 crisis. OBJECTIVE: We analysed excess mortality rates among the foreign-born population and changes in their distinctive mortality profiles ("migrant mortality advantage") during the first pandemic wave in France. DATA AND METHODS: Deaths from all causes in metropolitan France from March 18 to May 19, 2020 were used, with information on sex, age, region of residence and country of birth. Similar data from 2016 through 2019 were used for comparisons. RESULTS: During the pre-pandemic period (2016-2019), immigrant populations (except those from Central and Eastern Europe) had lower standardized mortality rates than the native-born population, with a particularly large advantage for immigrants from sub-Saharan Africa. In the regions most affected by COVID-19 (Grand-Est and Île-de-France), the differences in excess mortality by country of birth were large, especially in the working-age groups (40-69 years), with rates 8 to 9 times higher for immigrants from sub-Saharan Africa, and about 3 to 4 times higher for immigrants from North Africa, from the Americas and from Asia and Oceania relative to the native-born population. The relative overall mortality risk for men born in sub-Saharan Africa compared to native-born men, which was 0.8 before the pandemic, shifted to 1.8 during the first wave (0.9 to 1.5 for women). It also shifted from 0.8 to 1.1 for men from North Africa (0.9 to 1.1 for women), 0.7 to 1.0 for men from the Americas (0.9 to 1.3 for women), and 0.7 to 1.2 for men from Asia and Oceania (0.9 to 1.3 for women). CONCLUSION: Our findings shed light on the disproportionate impact of the first wave of the pandemic on the mortality of populations born outside Europe, with a specific burden of excess mortality within the working-age range, and a complete reversal of their mortality advantage. DA - 2022/11// PY - 2022 DO - 10.1016/j.socscimed.2022.115160 DP - PubMed VL - 313 SP - 115160 J2 - Soc Sci Med LA - eng SN - 1873-5347 KW - Adult KW - Aged KW - COVID-19 KW - Emigrants and Immigrants KW - Europe KW - Excess mortality KW - Female KW - Foreign-born KW - France KW - Humans KW - Immigrants KW - Inequalities KW - Male KW - Middle Aged KW - Migrant mortality advantage KW - Mortality KW - Pandemics ER - TY - JOUR TI - Daylight saving time affects European mortality patterns AU - Lévy, Laurent AU - Robine, Jean-Marie AU - Rey, Grégoire AU - Méndez Turrubiates, Raúl Fernando AU - Quijal-Zamorano, Marcos AU - Achebak, Hicham AU - Ballester, Joan AU - Rodó, Xavier AU - Herrmann, François R. T2 - Nature Communications AB - Daylight saving time (DST) consists in a one-hour advancement of legal time in spring offset by a backward transition of the same magnitude in fall. It creates a minimal circadian misalignment that could disrupt sleep and homoeostasis in susceptible individuals and lead to an increased incidence of pathologies and accidents during the weeks immediately following both transitions. How this shift affects mortality dynamics on a large population scale remains, however, unknown. This study examines the impact of DST on all-cause mortality in 16 European countries for the period 1998-2012. It shows that mortality decreases in spring and increases in fall during the first two weeks following each DST transition. Moreover, the alignment of time data around DST transition dates revealed a septadian mortality pattern (lowest on Sundays, highest on Mondays) that persists all-year round, irrespective of seasonal variations, in men and women aged above 40. DA - 2022/11/14/ PY - 2022 DO - 10.1038/s41467-022-34704-9 DP - PubMed VL - 13 IS - 1 SP - 6906 J2 - Nat Commun LA - eng SN - 2041-1723 KW - Circadian Rhythm KW - Europe KW - Female KW - Humans KW - Incidence KW - Male KW - Seasons KW - Sleep ER - TY - CONF TI - Clinical information extraction at the CLEF eHealth Evaluation lab 2016 AU - Névéol, Aurélie AU - Grouin, Cyril AU - Cohen, Kevin B AU - Hamon, Thierry AU - Lavergne, Thomas AU - Kelly, Liadh AU - Goeuriot, Lorraine AU - Rey, Grégoire AU - Robert, Aude AU - Tannier, Xavier AU - Zweigenbaum, Pierre DA - 2016/// PY - 2016 ER - TY - JOUR TI - Has the impact of heat waves on mortality changed in France since the European heat wave of summer 2003? A study of the 2006 heat wave AU - Fouillet, A. AU - Rey, G. AU - Wagner, V. AU - Laaidi, K. AU - Empereur-Bissonnet, P. AU - Le Tertre, A. AU - Frayssinet, P. AU - Bessemoulin, P. AU - Laurent, F. AU - De Crouy-Chanel, P. AU - Jougla, E. AU - Hémon, D. T2 - International Journal of Epidemiology AB - BACKGROUND: In July 2006, a lasting and severe heat wave occurred in Western Europe. Since the 2003 heat wave, several preventive measures and an alert system aiming at reducing the risks related to high temperatures have been set up in France by the health authorities and institutions. In order to evaluate the effectiveness of those measures, the observed excess mortality during the 2006 heat wave was compared to the expected excess mortality. METHODS: A Poisson regression model relating the daily fluctuations in summer temperature and mortality in France from 1975 to 2003 was used to estimate the daily expected number of deaths over the period 2004-2006 as a function of the observed temperatures. RESULTS: During the 2006 heat wave (from 11 to 28 July), about 2065 excess deaths occurred in France. Considering the observed temperatures and with the hypothesis that heat-related mortality had not changed since 2003, 6452 excess deaths were predicted for the period. The observed mortality during the 2006 heat wave was thus markedly less than the expected mortality (approximately 4400 less deaths). CONCLUSIONS: The excess mortality during the 2006 heat wave, which was markedly lower than that predicted by the model, may be interpreted as a decrease in the population's vulnerability to heat, together with, since 2003, increased awareness of the risk related to extreme temperatures, preventive measures and the set-up of the warning system. DA - 2008/04// PY - 2008 DO - 10.1093/ije/dym253 DP - PubMed VL - 37 IS - 2 SP - 309 EP - 317 J2 - Int J Epidemiol LA - eng SN - 1464-3685 ST - Has the impact of heat waves on mortality changed in France since the European heat wave of summer 2003? KW - Aged KW - Female KW - France KW - Heat Stress Disorders KW - Hot Temperature KW - Humans KW - Male KW - Middle Aged KW - Models, Biological KW - Models, Statistical KW - Mortality KW - Seasons KW - Temperature ER - TY - JOUR TI - Excess mortality related to the August 2003 heat wave in France AU - Fouillet, A. AU - Rey, G. AU - Laurent, F. AU - Pavillon, G. AU - Bellec, S. AU - Guihenneuc-Jouyaux, C. AU - Clavel, J. AU - Jougla, E. AU - Hémon, Denis T2 - International Archives of Occupational and Environmental Health AB - OBJECTIVES: From August 1st to 20th, 2003, the mean maximum temperature in France exceeded the seasonal norm by 11-12 degrees C on nine consecutive days. A major increase in mortality was then observed, which main epidemiological features are described herein. METHODS: The number of deaths observed from August to November 2003 in France was compared to those expected on the basis of the mortality rates observed from 2000 to 2002 and the 2003 population estimates. RESULTS: From August 1st to 20th, 2003, 15,000 excess deaths were observed. From 35 years age, the excess mortality was marked and increased with age. It was 15% higher in women than in men of comparable age as of age 45 years. Excess mortality at home and in retirement institutions was greater than that in hospitals. The mortality of widowed, single and divorced subjects was greater than that of married people. Deaths directly related to heat, heatstroke, hyperthermia and dehydration increased massively. Cardiovascular diseases, ill-defined morbid disorders, respiratory diseases and nervous system diseases also markedly contributed to the excess mortality. The geographic variations in mortality showed a clear age-dependent relationship with the number of very hot days. No harvesting effect was observed. CONCLUSIONS: Heat waves must be considered as a threat to European populations living in climates that are currently temperate. While the elderly and people living alone are particularly vulnerable to heat waves, no segment of the population may be considered protected from the risks associated with heat waves. DA - 2006/10// PY - 2006 DO - 10.1007/s00420-006-0089-4 DP - PubMed VL - 80 IS - 1 SP - 16 EP - 24 J2 - Int Arch Occup Environ Health LA - eng SN - 0340-0131 KW - Adolescent KW - Adult KW - Age Factors KW - Aged KW - Aged, 80 and over KW - Child KW - Child, Preschool KW - Female KW - France KW - Heat Stress Disorders KW - Hot Temperature KW - Humans KW - Infant KW - Male KW - Marital Status KW - Middle Aged KW - Poisson Distribution KW - Seasons KW - Sex Factors ER - TY - JOUR TI - Estimating the number of homeless deaths in France, 2008-2010 AU - Vuillermoz, Cécile AU - Aouba, Albertine AU - Grout, Lise AU - Vandentorren, Stéphanie AU - Tassin, Fanny AU - Vazifeh, Layla AU - Ghosn, Walid AU - Jougla, Eric AU - Rey, Grégoire T2 - BMC public health AB - BACKGROUND: The homeless population of France has increased by 50% over the last 10 years. Studies have shown that homelessness is associated with a high risk of premature death. The aim of this study was to estimate the number of homeless deaths in France between 2008 and 2010, using a reproducible method. METHODS: We used the capture-recapture method to estimate the number of homeless deaths in France using two independent sources. An associative register of homeless deaths was matched with the national exhaustive database of the medical causes of death, using several matching approaches based on various combinations of the following variables: gender, age, place of death, date of death. RESULTS: The estimated number of homeless deaths between 2008 and 2010 was 6730 (95% CI: [4381-9079]), a number greatly underestimated by the two sources considered separately (less than 20%). CONCLUSIONS: In the absence of a register of the homeless deaths, the capture-recapture method provides an order of magnitude for evaluation of the resources that may be allocated by policy makers to manage the issue. Based on common and routinely produced databases, this estimate may therefore be used to monitor the mortality of the homeless population. Further studies about homeless mortality, particularly on the lead causes of deaths, are needed to manage this issue and to implement strategy to decrease the number of homeless deaths. DA - 2014/// PY - 2014 DO - 10.1186/1471-2458-14-690 DP - NCBI PubMed VL - 14 SP - 690 J2 - BMC Public Health LA - eng SN - 1471-2458 ER - TY - JOUR TI - The timing of introduction of pharmaceutical innovations in seven European countries AU - Westerling, Ragnar AU - Westin, Marcus AU - McKee, Martin AU - Hoffmann, Rasmus AU - Plug, Iris AU - Rey, Grégoire AU - Jougla, Eric AU - Lang, Katrin AU - Pärna, Kersti AU - Alfonso, José L. AU - Mackenbach, Johan P. T2 - Journal of Evaluation in Clinical Practice AB - RATIONALE, AIMS AND OBJECTIVES: Differences in the performance of medical care may be due to variation in the introduction and diffusion of medical innovations. The objective of this paper is to compare seven European countries (United Kingdom, the Netherlands, West Germany, France, Spain, Estonia and Sweden) with regard to the year of introduction of six specific pharmaceutical innovations (antiretroviral drugs, cimetidine, tamoxifen, cisplatin, oxalaplatin and cyclosporin) that may have had important population health impacts. METHODS: We collected information on introduction and further diffusion of drugs using searches in the national and international literature, and questionnaires to national informants. We combined various sources of information, both official years of registration and other indicators of introduction (clinical trials, guidelines, evaluation reports, sales statistics). RESULTS AND CONCLUSIONS: The total length of the period between first and last introduction varied between 8 years for antiretroviral drugs and 22 years for cisplatin. Introduction in Estonia was generally delayed until the 1990s. The average time lags were smallest in France (2.2 years), United Kingdom (2.8 years) and the Netherlands (3.5 years). Similar rank orders were seen for year of registration suggesting that introduction lags are not only explained by differences in the process of registration. We discuss possible reasons for these between-country differences and implications for the evaluation of medical care. DA - 2014/08// PY - 2014 DO - 10.1111/jep.12122 DP - NCBI PubMed VL - 20 IS - 4 SP - 301 EP - 310 J2 - J Eval Clin Pract LA - eng SN - 1365-2753 ER - TY - JOUR TI - Automated comparison of last hospital main diagnosis and underlying cause of death ICD10 codes, France, 2008-2009 AU - Lamarche-Vadel, Agathe AU - Pavillon, Gérard AU - Aouba, Albertine AU - Johansson, Lars Age AU - Meyer, Laurence AU - Jougla, Eric AU - Rey, Grégoire T2 - BMC medical informatics and decision making AB - BACKGROUND: In the age of big data in healthcare, automated comparison of medical diagnoses in large scale databases is a key issue. Our objectives were: 1) to formally define and identify cases of independence between last hospitalization main diagnosis (MD) and death registry underlying cause of death (UCD) for deceased subjects hospitalized in their last year of life; 2) to study their distribution according to socio-demographic and medico-administrative variables; 3) to discuss the interest of this method in the specific context of hospital quality of care assessment. METHODS: 1) Elaboration of an algorithm comparing MD and UCD, relying on Iris, a coding system based on international standards. 2) Application to 421,460 beneficiaries of the general health insurance regime (which covers 70% of French population) hospitalized and deceased in 2008-2009. RESULTS: 1) Independence, was defined as MD and UCD belonging to different trains of events leading to death 2) Among the deaths analyzed automatically (91.7%), 8.5% of in-hospital deaths and 19.5% of out-of-hospital deaths were classified as independent. Independence was more frequent in elder patients, as well as when the discharge-death time interval grew (14.3% when death occurred within 30 days after discharge and 27.7% within 6 to 12 months) and for UCDs other than neoplasms. CONCLUSION: Our algorithm can identify cases where death can be considered independent from the pathology treated in hospital. Excluding these deaths from the ones allocated to the hospitalization process could contribute to improve post-hospital mortality indicators. More generally, this method has the potential of being developed and used for other diagnoses comparisons across time periods or databases. DA - 2014/// PY - 2014 DO - 10.1186/1472-6947-14-44 DP - NCBI PubMed VL - 14 SP - 44 J2 - BMC Med Inform Decis Mak LA - eng SN - 1472-6947 ER - TY - JOUR TI - Mortality Associated With Systemic Lupus Erythematosus in France Assessed by Multiple-Cause-of-Death Analysis AU - Thomas, Guillemette AU - Mancini, Julien AU - Jourde-Chiche, Noémie AU - Sarlon, Gabrielle AU - Amoura, Zahir AU - Harlé, Jean-Robert AU - Jougla, Eric AU - Chiche, Laurent T2 - Arthritis & Rheumatology AB - Objective To assess the mortality profile of systemic lupus erythematosus (SLE) patients in France using multiple-cause-of-death analysis. Methods Data were collected between 2000 and 2009 in the French Epidemiological Center for the Medical Causes of Death database, and death certificates issued upon the death of an adult for whom SLE was an underlying cause of death (UCD) or a non–underlying cause of death (NUCD) were evaluated using multiple-cause-of-death analysis. Sex, age, sex ratio, standardized mortality rates, as well as frequency of the various causes of death were assessed, at both a national and a regional level. For the main causes of death, the observed number of deaths in relation to the expected number of deaths (O:E ratio) (standardized for age and sex) was calculated. Results During the study period, 1,593 deaths related to SLE were identified. The mean ± SD age at death was 63.5 ± 18.4 years and the sex ratio (female:male) was 3.5. The mean standardized mortality rate was 3.2 per 1 million people (range 2.7–4.1). When SLE was the UCD (n = 637), the main NUCDs were cardiovascular diseases (49.5%), infectious diseases (24.5%), and renal failure (23.2%). When SLE was an NUCD (n = 956), the most common UCDs were cardiovascular diseases (35.7%), neoplasms (13.9%), and infectious diseases (10.3%). The overall O:E ratio was >1 for infectious and cardiovascular diseases and renal failure (especially among people TY - JOUR TI - Causes of death among HIV-infected patients in France in 2010 (national survey): trends since 2000 AU - Morlat, Philippe AU - Roussillon, Caroline AU - Henard, Sandrine AU - Salmon, Dominique AU - Bonnet, Fabrice AU - Cacoub, Patrice AU - Georget, Aurore AU - Aouba, Albertine AU - Rosenthal, Eric AU - May, Thierry AU - Chauveau, Marie AU - Diallo, Bilghissa AU - Costagliola, Dominique AU - Chene, Geneviève AU - for the ANRS EN20 Mortalité 2010 Study Group T2 - AIDS (London, England) AB - OBJECTIVE:: The Mortalité 2010 survey aimed at describing the causes of death among HIV-infected patients in France in 2010 and their evolution since 2000. DESIGN AND METHODS:: A national sample of clinical sites, providing HIV care and treatment, notified and documented deaths using a standardized questionnaire. RESULTS:: The 90 participating wards notified 728 deaths. Median age at death was 50 years (interquartile range 45-58) and 75% were men. The main underlying causes of death were AIDS-related (25% in 2010 vs. 36% in 2005 and 47% in 2000), non-AIDS non-viral hepatitis-related malignancy (22 vs. 17 and 11%), liver-related (11 vs. 15 and 13%), cardiovascular diseases (10 vs. 8 and 7%) and non-AIDS-related infections (9 vs. 4 and 7%). Malignancies (AIDS and non-AIDS-related) accounted for a third of all causes of death. AIDS accounted for 33% of all causes of death among patients mono-infected with HIV vs. only 13% among those co-infected with hepatitis B virus or hepatitis C virus. CONCLUSION:: In 2010, 25% of the causes of death among HIV-infected patients remained AIDS-related. Improved screening and earlier HIV treatment should lead to a smaller proportion of deaths due to AIDS. The majority of patients died of various causes, whereas their HIV infection was well controlled under treatment. Improving case management of HIV-infected patients should include a multidisciplinary approach (prevention, screening, treatment), especially in oncology. Smoking cessation should be a priority goal. DA - 2014/05/15/ PY - 2014 DO - 10.1097/QAD.0000000000000222 DP - NCBI PubMed VL - 28 IS - 8 SP - 1181 EP - 1191 J2 - AIDS LA - ENG SN - 1473-5571 ST - Causes of death among HIV-infected patients in France in 2010 (national survey) ER - TY - JOUR TI - Deaths associated with acquired haemophilia in France from 2000 to 2009: multiple cause analysis for best care strategies AU - Aouba, A AU - Rey, G AU - Pavillon, G AU - Jougla, E AU - Rothschild, C AU - Torchet, M-F AU - Guillevin, L AU - Hermine, O AU - Aouba, A T2 - Haemophilia: the official journal of the World Federation of Hemophilia AB - Deaths occurring in the context of acquired haemophilia (AH) may be related to inter-connected causes and mechanisms including bleeding, specific or older patient co-morbidities or iatrogenic complications. However, their magnitude remains unknown. This study aimed to determine the respective weight and frequency of the various causes of death in AH. Multiple-cause analysis based on death certificates data is used in this purpose. Over a 10-year period (2000-2009), 121 deaths with AH as a cause were registered in France. All the deaths were of adults (extremes: 47 and 99 years; mean age: 80.7 years). The average number of causes per death certificate was 4.7. AH was the underlying cause of death (UCD) in 69.4% of the cases, and was more frequent in the older subjects. In contrast, before age of 75 years, AH was more often a contributing cause of death. No postpartum or obvious thromboembolism-related deaths were registered. Haemorrhagic shock was the most frequent direct cause of death (DCD), followed by infectious events, cardiac dysfunction, metabolic and nutritional disorders with muscle wasting and decubitus complications, and cancers (52.9%, 26.4%, 7.5%, 5.8% and 4.1%, respectively). However, when AH was not reported as an UCD, infections become the first DCD (32.4%) followed by bleeding events (16.2%). Best prophylactic and curative strategies for infections are particularly required to improve the prognosis in AH. Moreover, as several of its DCD correspond also to steroids side effects, best tolerated immunosuppressant regimen with steroid-sparing agents adjoining are particularly awaited in AH population. DA - 2012/05// PY - 2012 DO - 10.1111/j.1365-2516.2011.02647.x DP - NCBI PubMed VL - 18 IS - 3 SP - 339 EP - 344 J2 - Haemophilia LA - eng SN - 1365-2516 ST - Deaths associated with acquired haemophilia in France from 2000 to 2009 KW - Adolescent KW - Adult KW - Age Distribution KW - Aged KW - Aged, 80 and over KW - Child KW - Child, Preschool KW - Female KW - France KW - Hemophilia A KW - Humans KW - Infant KW - Male KW - Middle Aged KW - Sex Distribution KW - Young Adult ER - TY - JOUR TI - Role of cancer treatment in long-term overall and cardiovascular mortality after childhood cancer AU - Tukenova, Markhaba AU - Guibout, Catherine AU - Oberlin, Odile AU - Doyon, Françoise AU - Mousannif, Abdeddahir AU - Haddy, Nadia AU - Guérin, Sylvie AU - Pacquement, Hélène AU - Aouba, Albertine AU - Hawkins, Mike AU - Winter, Dave AU - Bourhis, Jean AU - Lefkopoulos, Dimitri AU - Diallo, Ibrahima AU - de Vathaire, Florent T2 - Journal of clinical oncology: official journal of the American Society of Clinical Oncology AB - PURPOSE: The purpose of this study was to assess the role of treatment in long-term overall and cardiovascular mortality after childhood cancer. PATIENTS AND METHODS: We studied 4,122 5-year survivors of a childhood cancer diagnosed before 1986 in France and the United Kingdom. Information on chemotherapy was collected, and the radiation dose delivered to the heart was estimated for 2,870 patients who had received radiotherapy. RESULTS: After 86,453 person-years of follow-up (average, 27 years), 603 deaths had occurred. The overall standardized mortality ratio (SMR) was 8.3-fold higher (95% CI, 7.6-fold to 9.0-fold higher) in relation to the general populations in France and the United Kingdom. Thirty-two patients had died as a result of cardiovascular diseases (ie, 5.0-fold [95% CI, 3.3-fold to 6.7-fold] more than expected). The risk of dying as a result of cardiac diseases (n = 21) was significantly higher in individuals who had received a cumulative anthracycline dose greater than 360 mg/m(2) (relative risk [RR], 4.4; 95% CI, 1.3 to 15.3) and in individuals who received an average radiation dose that exceeded 5 Gy (RR, 12.5 and 25.1 for 5 to 14.9 Gy and > 15 Gy, respectively) to the heart. A linear relationship was found between the average dose of radiation to the heart and the risk of cardiac mortality (estimated excess [corrected] RR at 1 Gy, 60%). CONCLUSION: This study is the first, to our knowledge, to establish a relationship between the radiation dose received by the heart during radiotherapy for a childhood cancer and long-term cardiac mortality. This study also confirms a significant excess risk of cardiac mortality associated with a high cumulative dose of anthracyclines. DA - 2010/03/10/ PY - 2010 DO - 10.1200/JCO.2008.20.2267 DP - NCBI PubMed VL - 28 IS - 8 SP - 1308 EP - 1315 J2 - J. Clin. Oncol. LA - eng SN - 1527-7755 KW - Adolescent KW - Adult KW - Anthracyclines KW - Antineoplastic Agents KW - Cardiovascular Diseases KW - Child KW - Child, Preschool KW - Dose-Response Relationship, Drug KW - Dose-Response Relationship, Radiation KW - Female KW - Follow-Up Studies KW - France KW - Great Britain KW - Humans KW - Male KW - Middle Aged KW - Mortality KW - Multivariate Analysis KW - Neoplasms KW - Radiotherapy KW - Survivors ER - TY - JOUR TI - [The confidential enquiries into maternal deaths, 1996-2006 in France: what consequences for the obstetrical care?] AU - Bouvier-Colle, M-H AU - Saucedo, M AU - Deneux-Tharaux, C AU - CNEMM T2 - Journal de gynécologie, obstétrique et biologie de la reproduction AB - The national confidential enquiry into maternal deaths (ENCMM) and its committee (CNEMM) have the target to study all maternal deaths occurring in France, in order to expertise the care provided. The current report covers the 1996--year of the ENCMM establishment--to 2006 years. After being informed of the potential maternal deaths by the Epidemiological center on medical causes of deaths (CépiDC), and agreement from the medical doctors concerned, two assessors (one anesthetist and one obstetrician) gather the medical or obstetrical information near the team involved in the care of the women, by the mean of a detailed and specific questionnaire. The completely anonymous files are expertised by the CNEMM. Maternal mortality rates have been calculated by periods, the distribution of the obstetrical causes and the characteristics of the dead women were calculated too. The substandard care and the avoidability of deaths were estimated by subgroup. Since 1996 to 2006, 729 maternal deaths were included of which 553 were expertised. The majority of maternal deaths were due to direct obstetrical causes (73%) mainly haemorrhages (22%), amniotic fluid embolism (12%), complications of hypertension (10 %), and venous thrombo-embolism (around 10 % each). Half of maternal deaths were considered preventable by the CNEMM, particularly haemorrhage and sepsis. The factors of avoidability are delay to treat (31%) inadapted therapeutics (28%), even professional default (20%) no diagnosis (15%) or reluctant patient (7%). Seven deaths are discussed in a specific section including a detailed description of, and recommendations on how the quality of care may be improved. DA - 2011/04// PY - 2011 DO - 10.1016/j.jgyn.2010.12.007 DP - NCBI PubMed VL - 40 IS - 2 SP - 87 EP - 102 J2 - J Gynecol Obstet Biol Reprod (Paris) LA - fre SN - 0368-2315 ST - [The confidential enquiries into maternal deaths, 1996-2006 in France KW - Adult KW - Confidentiality KW - Embolism, Amniotic Fluid KW - Female KW - France KW - Humans KW - Hypertension, Pregnancy-Induced KW - Maternal Mortality KW - Postpartum Hemorrhage KW - Pregnancy KW - Venous Thromboembolism ER - TY - JOUR TI - Long-term mortality after recombinant growth hormone treatment for isolated growth hormone deficiency or childhood short stature: preliminary report of the French SAGhE study AU - Carel, Jean-Claude AU - Ecosse, Emmanuel AU - Landier, Fabienne AU - Meguellati-Hakkas, Djamila AU - Kaguelidou, Florentia AU - Rey, Grégoire AU - Coste, Joël T2 - The Journal of clinical endocrinology and metabolism AB - CONTEXT: Little is known about the long-term health of subjects treated with GH in childhood, and Safety and Appropriateness of Growth hormone treatments in Europe (SAGhE) is a study addressing this question. OBJECTIVE: The objective of the study was to evaluate the long-term mortality of patients treated with recombinant GH in childhood in France. DESIGN: This was a population-based cohort study. SETTING: The setting of the study was a French population-based register. PARTICIPANTS: A total of 6928 children with idiopathic isolated GH deficiency (n = 5162), neurosecretory dysfunction (n = 534), idiopathic short stature (n = 871), or born short for gestational age (n = 335) who started treatment between 1985 and 1996 participated in the study. Follow-up data on vital status were available in September 2009 for 94.7% of the patients. MAIN OUTCOME MEASURES: All-cause and cause-specific mortality was measured in the study. RESULTS: All-cause mortality was increased in treated subjects [standardized mortality ratio (SMR) 1.33, 95% confidence interval (CI) 1.08-1.64]. In a multivariate analysis adjusted for height, the use of GH doses greater than 50 μg/kg · d was associated with mortality rates using external and internal references (SMR 2.94, 95% CI 1.22-7.07, hazard ratio 2.79, 95% CI 1.14-6.82). All type cancer-related mortality was not increased. Bone tumor-related mortality was increased (SMR 5.00, 95% CI 1.01-14.63). An increase in mortality due to diseases of the circulatory system (SMR 3.07, 95% CI 1.40-5.83) or subarachnoid or intracerebral hemorrhage (SMR 6.66, 95% CI 1.79-17.05) was observed. CONCLUSIONS: Mortality rates were increased in this population of adults treated as children with recombinant GH, particularly in those who had received the highest doses. Specific effects were detected in terms of death due to bone tumors or cerebral hemorrhage but not for all cancers. These results highlight the need for additional studies of long-term mortality and morbidity after GH treatment in childhood. DA - 2012/02// PY - 2012 DO - 10.1210/jc.2011-1995 DP - NCBI PubMed VL - 97 IS - 2 SP - 416 EP - 425 J2 - J. Clin. Endocrinol. Metab. LA - eng SN - 1945-7197 ST - Long-term mortality after recombinant growth hormone treatment for isolated growth hormone deficiency or childhood short stature KW - Adolescent KW - Adult KW - Age of Onset KW - Aged KW - Algorithms KW - Child KW - Child, Preschool KW - Cohort Studies KW - Female KW - Follow-Up Studies KW - France KW - Growth Disorders KW - Growth Hormone KW - Human Growth Hormone KW - Humans KW - Male KW - Middle Aged KW - Population KW - Recombinant Proteins KW - Time Factors KW - Young Adult ER - TY - JOUR TI - Counting the dead and what they died of AU - Johansson, Lars Age AU - Pavillon, Gérard AU - Anderson, Robert AU - Glenn, Donna AU - Griffiths, Clare AU - Hoyert, Donna AU - Jackson, Graham AU - Notzon, F Sam AU - Rooney, Cleo AU - Rosenberg, Harry M AU - Walker, Sue AU - Weber, Stefanie T2 - Bulletin of the World Health Organization DA - 2006/03// PY - 2006 DO - /S0042-96862006000300023 DP - NCBI PubMed VL - 84 IS - 3 SP - 254 J2 - Bull. World Health Organ. LA - eng SN - 0042-9686 KW - Developing Countries KW - Humans KW - Mortality KW - Research Design ER - TY - JOUR TI - Can mortality data provide reliable indicators for Creutzfeldt-Jakob disease surveillance? A study in France from 2000 to 2008 AU - Brandel, Jean-Philippe AU - Welaratne, Arlette AU - Salomon, Dominique AU - Capek, Isabelle AU - Vaillant, Véronique AU - Aouba, Albertine AU - Aouaba, Albertine AU - Haïk, Stéphane AU - Alpérovitch, Annick T2 - Neuroepidemiology AB - BACKGROUND: Surveillance of Creutzfeldt-Jakob disease (CJD) is still an important issue because of the variant CJD epidemic, which is in decline and also because of the emergence of novel forms of animal transmissible spongiform encephalopathy with zoonotic potential and the risk of nosocomial and blood transfusion-related transmission. Active surveillance has been implemented in most European countries and requires important human resources and funding. Here, we studied whether national mortality and morbidity statistics can be used as reliable indicators. METHODS: CJD data collected by the French national CJD surveillance centre were compared with data registered in the national mortality statistics. RESULTS: From 2000 to 2008, the two sources reported fairly similar numbers of CJD deaths. However, analysis of individual data showed important between-sources disagreement. Nearly 24% of CJD reported by the mortality register were false-positive diagnoses and 21.6% of the CJD cases diagnosed by the surveillance centre were not registered as CJD in the national mortality statistics. One out of 22 variant CJD cases was not reported as having any type of CJD in the mortality statistics. CONCLUSIONS: These findings raise doubt about the possibility of a reliable CJD surveillance only based on mortality data. DA - 2011/// PY - 2011 DO - 10.1159/000332764 DP - NCBI PubMed VL - 37 IS - 3-4 SP - 188 EP - 192 J2 - Neuroepidemiology LA - eng SN - 1423-0208 ST - Can mortality data provide reliable indicators for Creutzfeldt-Jakob disease surveillance? KW - Aged KW - Aged, 80 and over KW - Creutzfeldt-Jakob Syndrome KW - Diagnostic Errors KW - Female KW - France KW - Humans KW - Male KW - Middle Aged KW - Population Surveillance KW - Registries KW - Reproducibility of Results ER - TY - JOUR TI - Defective dendritic cell function in HIV-infected patients receiving effective highly active antiretroviral therapy: neutralization of IL-10 production and depletion of CD4+CD25+ T cells restore high levels of HIV-specific CD4+ T cell responses induced by dendritic cells generated in the presence of IFN-alpha AU - Carbonneil, Cédric AU - Donkova-Petrini, Vladimira AU - Aouba, Albertine AU - Weiss, Laurence T2 - Journal of immunology (Baltimore, Md.: 1950) AB - We previously demonstrated that GM-CSF/IFN-alpha combination allowed the differentiation of monocytes from HIV-infected patients into dendritic cells (DCs) exhibiting high CD8(+) T cell stimulating abilities. The present study was aimed at characterizing the ability of DCs generated in the presence of GM-CSF and IFN-alpha to induce CD4 T cell responses. DCs were generated from monocytes of HIV-infected patients in the presence of GM-CSF with either IFN-alpha (IFN-DCs) or IL-4 (IL-4-DCs) for 7 days. Eleven patients receiving highly active antiretroviral therapy and exhibiting CD4 cell counts above 400/mm(3) and plasma HIV-RNA TY - JOUR TI - Suboptimal care in the initial management of children who died from severe bacterial infection: a population-based confidential inquiry AU - Launay, Elise AU - Gras-Le Guen, Christèle AU - Martinot, Alain AU - Assathiany, Rémy AU - Blanchais, Thomas AU - Mourdi, Nadjette AU - Aouba, Albertine AU - Bouvier-Colle, Marie-Hélène AU - Rozé, Jean-Christophe AU - Chalumeau, Martin T2 - Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies AB - OBJECTIVES: To study the frequency and types of suboptimal care and medical errors in children who died of severe bacterial infection as the first-stage procedure intended to improve quality of care. DESIGN: Population-based confidential inquiry. SETTING: Two adjoining administrative districts in France. PATIENTS: Children older than 3 months dead from severe bacterial infection from 2000 through 2006. INTERVENTIONS: The medical files were summarized on standardized forms and then evaluated independently by two experts, who determined whether the initial management before the patients' arrival in intensive care was or was not optimal, in comparison with current guidelines. MEASUREMENTS AND MAIN RESULTS: Of 23 deaths from severe bacterial infection, 21 could be analyzed; management was considered suboptimal in 76%. The coefficient of agreement between the experts was high, with a weighted kappa of 0.73. The types of errors identified included parental delay in seeking medical care (33%; 95% confidence interval, [12-54]), physicians' delay in administering appropriate treatment (antibiotic therapy in the case of purpura; 38%; 95% confidence interval, 16-60), insufficient doses of or failure to repeat fluid resuscitation (24%; 95% confidence interval, [9 -35]), and overall underestimation of disease severity (38%; 95% confidence interval, [16-60]). CONCLUSION: This study found a high frequency of suboptimal care in the initial management of children who died of severe bacterial infection, with four separate types of errors. Other studies are needed to assess the potential avoidability of this type of death. DA - 2010/07// PY - 2010 DO - 10.1097/PCC.0b013e3181ce752e DP - NCBI PubMed VL - 11 IS - 4 SP - 469 EP - 474 J2 - Pediatr Crit Care Med LA - eng SN - 1529-7535 ST - Suboptimal care in the initial management of children who died from severe bacterial infection KW - Bacterial Infections KW - Child KW - Child, Preschool KW - Female KW - France KW - Hospital Mortality KW - Humans KW - Infant KW - Male KW - Quality of Health Care KW - Retrospective Studies KW - Severity of Illness Index ER - TY - JOUR TI - Changing mortality for motor neuron disease in France (1968-2007): an age-period-cohort analysis AU - Gordon, Paul H AU - Artaud, Fanny AU - Aouba, Albertine AU - Laurent, Françoise AU - Meininger, Vincent AU - Elbaz, Alexis T2 - European journal of epidemiology AB - The incidence and mortality of motor neuron disease (MND) increase with age and appear to have increased with time. The examination of period and cohort effects using age-period-cohort (APC) models can help characterize temporal trends. Our objective was to describe mortality from MND in France (1968-2007), and to examine the role of age, period of death, and birth-cohort on changes in mortality. The number of people who died from MND and population statistics (1968-2007) were extracted from French national records. Annual standardized (age/sex) mortality ratios (SMRs) were computed. Using Poisson regression, APC models examined the relationship between mortality rates and age, period of death, and birth-cohort in subjects aged 40-89 years. Deviance/degrees-of-freedom ratios evaluated model fit; ratios close to one indicated adequate fit. Between 1968 and 2007, 38,863 individuals died from MND (mortality rate = 1.74/100,000); 37,624 were aged 40-89 years. SMRs increased from 54 (95% CI = 49-59) in 1968 to 126 (120-132) in 2007. Male-to-female ratios declined from 1.80 in 1968 to 1.45 in 2007. Changing mortality rates were best explained by cohort effects (deviance/degrees-of-freedom = 1.09). The relative risk of dying from MND increased markedly for persons born between 1880 and 1920, and more slowly after 1920. In conclusion, mortality rates for MND increased between 1968 and 2007, and more rapidly in women than men. This increase was better explained by the birth-cohort of individuals than by period effects. Changing environmental exposures may be a possible explanation and these findings warrant the continued search for environmental risk factors for MND. DA - 2011/09// PY - 2011 DO - 10.1007/s10654-011-9595-0 DP - NCBI PubMed VL - 26 IS - 9 SP - 729 EP - 737 J2 - Eur. J. Epidemiol. LA - eng SN - 1573-7284 ST - Changing mortality for motor neuron disease in France (1968-2007) KW - Adolescent KW - Adult KW - Age Factors KW - Aged KW - Aged, 80 and over KW - Cohort Studies KW - European Continental Ancestry Group KW - Female KW - France KW - Humans KW - Male KW - Middle Aged KW - Models, Statistical KW - Mortality KW - Motor Neuron Disease KW - Population Surveillance KW - Risk Assessment KW - Risk Factors KW - Sex Distribution KW - Sex Factors KW - Time Factors ER - TY - JOUR TI - Covid-19 : troisième cause de décès en France en 2020, quand les autres grandes causes de décès baissent AU - Fouillet, Anne AU - Ghosn, Walid AU - Naouri, Diane AU - Coudin, Elise T2 - Etudes et résultats AB - En 2020, le Covid-19 a entraîné le décès de 69 000 personnes en France (10,4 % des décès), ce qui en a fait la troisième cause la plus importante de décès pour cette année. Un peu plus de la moitié des victimes du Covid-19 avaient 85 ans ou plus, les hommes décédés du Covid-19 étant en moyenne plus jeunes que les femmes. Les causes de décès les plus fréquentes en 2020 restent les tumeurs (25,6 %) et les maladies cardio-neurovasculaires (20,2 %). Le nombre de décès de ces deux groupes de maladies est cependant en baisse par rapport aux années passées, ce qui pourrait être dû en partie au fait que certaines personnes malades ou fragiles, qui seraient décédées pour ces raisons dans l’année, ont finalement péri à cause du Covid-19 (effet compétitif). Par ailleurs, les mesures prises pour limiter l’impact de la crise sanitaire (confinements, port du masque, gestes barrières) ont sans doute été à l’origine du recul de la mortalité constatée pour les maladies de l’appareil respiratoire, les maladies infectieuses et les accidents de la route. En 2020, aucune cause de mortalité n’a augmenté directement ou indirectement du fait du Covid-19, ce qui explique que l’excès global de mortalité observé en 2020 (47 000 décès en plus par rapport à ce qui était attendu) ait été inférieur au nombre de décès dus directement au Covid-19. DA - 2022/// PY - 2022 IS - 1250 SP - 1 EP - 7 ER - TY - JOUR TI - Covid-19 : troisième cause de décès en France en 2020, quand les autres grandes causes baissent AU - Fouillet, Anne AU - Ghosn, Walid AU - Naouri, Diane AU - Coudin, Elise T2 - Bull Epidémiol Hebd AB - Introduction – L’année 2020 a été marquée par la pandémie de Covid-19, qui a eu des effets directs et potentiellement indirects sur la mortalité. Cette étude décrit les principaux indicateurs de mortalité par cause en 2020 et les compare à ceux observés en 2015-2017. Méthodes – À partir des certificats de décès des personnes résidentes et décédées en France métro politaine et dans les départements et régions d’outre-mer (DROM) en 2020, et 2015-2017 (période de référence), les causes médicales ont été codées selon la classification internationale des maladies (CIM10 version 19) et les règles de l’Organisation mondiale de la Santé. Les causes initiales de l’ensemble des décès ont été regroupées selon la liste européenne des causes de décès, à laquelle une catégorie spécifique pour la Covid-19 a été ajoutée. Les effectifs de décès et les taux de mortalité standardisés sur la population standard européenne d’Eurostat (European Standard Population) ont été analysés par cause, classe d’âge et sexe. Résultats – Avec environ 69 000 décès, la Covid-19 constitue la troisième cause de décès en France en 2020, derrière les tumeurs et les maladies de l’appareil circulatoire. Hors Covid-19, les mortalités selon les principales causes de décès sont majoritairement en baisse par rapport aux tendances des années 2015-2017. Discussion – Le nombre de décès dus à la Covid-19 dépasse l’excédent de décès toutes causes confondues estimé par l’Institut national de la statistique et des études économiques (Insee) (47 000) car la mortalité hors Covid-19 baisse. Ceci suggère une concurrence entre la Covid-19 et les autres grandes causes (tumeurs, maladies de l’appareil circulatoire), ainsi qu’un effet protecteur, notamment contre les maladies respiratoires et infectieuses et les accidents de transport, lié aux mesures de prévention qui ont accompagné la crise sanitaire. Toutefois, d’autres impacts de cette épidémie et de son contexte ne peuvent être exclus, ce qui implique de répéter l’analyse quand un recul plus important sera disponible. DA - 2022/// PY - 2022 VL - Cov_16 SP - 2 EP - 15 ER - TY - JOUR TI - Les statistiques provisoires sur les causes de décès en 2018 et 2019 - Une nouvelle méthode de codage faisant appel à l’intelligence artificielle AU - Clanché, François AU - Razakamanana, Nirintsoa AU - Coudin,Elise AU - Robert, Aude T2 - Drees - Méthodes DA - 2023/// PY - 2023 VL - 8 ER - TY - JOUR TI - Reactive surveillance of suicides during the COVID-19 pandemic in France, 2020 to March 2022 AU - Fouillet, A., Martin, D., Pontais, I., Caserio-Schönemann, C., & Rey, G. T2 - Epidemiology and Psychiatric Sciences DA - 2023/// PY - 2023 DO - 10.1017/S2045796023000148 VL - 32 IS - E20 ER - TY - RPRT TI - Combining a deep-learning-based approach, rule- based automated expert system and targeted manual coding for ICD-10 cause of death coding of French death certificates in 2018 - 2019 AU - Zambetta, Elisa AU - Razakamanana, Nirintsoa AU - Robert, Aude AU - Clanché, François AU - Martin, Diane AU - Hebbache, Zina AU - Flicoteaux, Rémi AU - Coudin, Elise T2 - Document de travail du CépiDc DA - 2023/09// PY - 2023 LA - english M3 - Document de travail PB - Centre d'épidémiologie sur les causes de décès - CépiDc- Inserm SN - 2/2023 UR - https://www.cepidc.inserm.fr/documentation/codage-des-causes-de-deces-de-2018-et-2019-en-cim10-approche-combinant-deep-learning-systeme-expert-et-codage-manuel-cible-document-de-travail-cepidc-n22023 ER - TY - RPRT TI - Codage des causes de décès de 2018 et 2019 en CIM10 - Approche combinant deep learning, système expert et codage manuel ciblé AU - Zambetta, Elisa AU - Razakamanana, Nirintsoa AU - Robert, Aude AU - Clanché, François AU - Rivera, Cecilia AU - Martin, Diane AU - Hebbache, Zina AU - Flicoteaux, Rémi AU - Coudin, Elise T2 - Document de travail du CépiDc DA - 2023/09// PY - 2023 LA - français M3 - Document de travail PB - Centre d'épidémiologie sur les causes médicales de décès SN - 2 (version française) UR - https://www.cepidc.inserm.fr/documentation/codage-des-causes-de-deces-de-2018-et-2019-en-cim10-approche-combinant-deep-learning-systeme-expert-et-codage-manuel-cible-document-de-travail-cepidc-n22023 ER - TY - JOUR TI - Grandes causes de mortalité en France en 2021 et tendances récentes AU - Fouillet, Anne AU - Ghosn, Walid AU - Rivera, Cecilia AU - Clanché, François AU - Coudin, Elise T2 - Bulletin épidémiologique hebdomadaire DA - 2023/12// PY - 2023 VL - 26 SP - 554 EP - 69 ER - TY - JOUR TI - Grandes causes de décès en France en 2021 : une année encore fortement marquée par le Covid-19 AU - Cadillac, Manon AU - Fouillet, Anne AU - Rivera, Cecilia AU - Clanché, François AU - Coudin, Elise T2 - Etudes et Résultats DA - 2023/12// PY - 2023 VL - 1288 ER -