TY - JOUR TI - Giant-cell arteritis-related mortality in France: A multiple-cause-of-death analysis AU - Chazal, Thibaud AU - Lhote, Raphael AU - Rey, Grégoire AU - Haroche, Julien AU - Eb, Mireille AU - Amoura, Zahir AU - Cohen Aubart, Fleur T2 - Autoimmunity Reviews AB - OBJECTIVES: Giant-cell arteritis (GCA) is a large vessel vasculitis. Data regarding mortality are controversial. We describe the mortality data of the French death certificates for the period of 2005 to 2014. METHODS: Using multiple-cause-of-death (MCOD) analysis, we calculated age-adjusted mortality rates for GCA, examined differences in mortality rates according to age and gender and analyzed the underlying causes of death (UCD). RESULTS: We analyzed 4628 death certificates listing a diagnosis of GCA as UCD or non-underlying cause of death (NUCD). The mean age of death was 86 (±6.8) years. The overall age-standardized mortality rate among GCA patients was 7.2 per million population. Throughout the study period, the mean age of death was significantly increased (r = 0.17, p  1 in GCA-associated mortality compared with the general population mortality was observed for tuberculosis, pneumonia and cardiovascular diseases. CONCLUSION: In this analysis of French death certificates mentioning GCA, we observed a stable standardized mortality rate between 2005 and 2014. The most frequent associated diseases were cardiovascular diseases and infections. DA - 2018/12// PY - 2018 DO - 10.1016/j.autrev.2018.06.012 DP - PubMed VL - 17 IS - 12 SP - 1219 EP - 1224 J2 - Autoimmun Rev LA - eng SN - 1873-0183 ST - Giant-cell arteritis-related mortality in France KW - Cardiovascular Diseases KW - Cause of Death KW - Communicable Diseases KW - Death Certificates KW - Epidemiology. KW - France KW - Giant Cell Arteritis KW - Giant—cell arteritis KW - Humans KW - Mortality KW - Neoplasms KW - Neurodegenerative Diseases KW - Prognosis KW - Survival Rate ER -