TY - JOUR TI - Liver disease as a major cause of death among HIV infected patients: role of hepatitis C and B viruses and alcohol AU - Salmon-Ceron, Dominique AU - Lewden, Charlotte AU - Morlat, Philippe AU - Bévilacqua, Sibylle AU - Jougla, Eric AU - Bonnet, Fabrice AU - Héripret, Laurence AU - Costagliola, Dominique AU - May, Thierry AU - Chêne, Geneviève AU - Mortality 2000 study group T2 - Journal of hepatology AB - BACKGROUND/AIMS: We analyzed the characteristics of HIV infected patients who died from liver disease, focusing on hepatitis virus co-infection. METHODS: One-hundred and eighty-five French hospital departments involved in HIV/AIDS management prospectively notified all deaths occurring in 2000. Patients whose hepatitis C (HCV) and hepatitis B (HBV) serostatus was known were classified as being infected by HCV alone, HBV alone (HBsAg positive), both HCV and HBV, or neither HCB nor HBV. RESULTS: Among 822 HIV infected patients, 29% were infected by HCV alone, 8% by HBV alone, and 4% by both HCV and HBV. The most frequent causes of death were liver disease (31% of cases) and AIDS (29%) among HIV-HCV co-infected patients, and AIDS (38%) and liver disease (22%) among HIV-HBV co-infected patients. Liver disease was a more frequent cause of death among patients co-infected by both HCV and HBV (44% of cases). Hepatocellular carcinoma was present in 15% of patients who died from liver disease, and was associated with HBV co-infection. Nearly half the patients who died from liver disease had more than 200 CD4/mm3. CONCLUSIONS: Liver disease is now a leading cause of death among HIV-HCV co-infected patients and is becoming an important cause of death among HIV-HBV co-infected patients. The risk of death from liver disease is highest in patients co-infected by both HCV and HBV. DA - 2005/06// PY - 2005 DP - NCBI PubMed VL - 42 IS - 6 SP - 799 EP - 805 J2 - J. Hepatol. LA - eng SN - 0168-8278 ST - Liver disease as a major cause of death among HIV infected patients KW - Adult KW - Antiviral Agents KW - Comorbidity KW - Data Collection KW - Female KW - France KW - HIV Infections KW - Hepatitis B KW - Hepatitis C KW - Humans KW - Liver Diseases, Alcoholic KW - Male KW - Risk Factors KW - Seroepidemiologic Studies ER -