TY - JOUR TI - Changes in causes of death among adults infected by HIV between 2000 and 2005: The "Mortalité 2000 and 2005" surveys (ANRS EN19 and Mortavic) AU - Lewden, Charlotte AU - May, Thierry AU - Rosenthal, Eric AU - Burty, Christine AU - Bonnet, Fabrice AU - Costagliola, Dominique AU - Jougla, Eric AU - Semaille, Caroline AU - Morlat, Philippe AU - Salmon, Dominique AU - Cacoub, Patrice AU - Chêne, Geneviève AU - ANRS EN19 Mortalité Study Group and Mortavic1 T2 - Journal of acquired immune deficiency syndromes (1999) AB - BACKGROUND: The multicenter national Mortalité 2005 survey aimed at describing the distribution of causes of death among HIV-infected adults in France in 2005 and its changes as compared with 2000. METHODS: Physicians involved in the management of HIV infection notified deaths and documented the causes using a standardized questionnaire similar to the previous survey performed in 2000. RESULTS: Overall, 1042 deaths were notified in 2005 (vs 964 in 2000): with median age, 46 years (vs 41 years); men, 76%; and median last CD4 cell count, 161/mm (vs 94). The proportion of underlying causes of death due to AIDS decreased (36% in 2005 vs 47% in 2000), and the proportion of cancer not related to AIDS or hepatitis (17% vs 11%), liver related disease (15% vs 13%: hepatitis C, 11%, and hepatitis B, 2%), cardiovascular disease (8% vs 7%), or suicide (5% vs 4%) increased. Among the 375 AIDS-related deaths, the most frequent event was non-Hodgkin lymphoma (28%). Among cancers not related to AIDS or hepatitis, the most frequent localizations were lung (31%) and digestive tract (14%). Among the 154 liver-related deaths, 24% were due to hepatocarcinoma. CONCLUSIONS: The heterogeneity of causes of death among HIV-infected adults was confirmed and intensified in 2005, with 3 causes following AIDS: cancers and liver-related and cardiovascular diseases. DA - 2008/08/15/ PY - 2008 DO - 10.1097/QAI.0b013e31817efb54 DP - NCBI PubMed VL - 48 IS - 5 SP - 590 EP - 598 J2 - J. Acquir. Immune Defic. Syndr. LA - eng SN - 1525-4135 ST - Changes in causes of death among adults infected by HIV between 2000 and 2005 KW - Acquired Immunodeficiency Syndrome KW - Adult KW - Cardiovascular Diseases KW - Female KW - Humans KW - Liver Diseases KW - Male KW - Middle Aged KW - Neoplasms KW - Questionnaires ER -