TY - JOUR TI - TIME TREND IN EXCESS MORTALITY IN CHILDREN WITH TYPE 1 DIABETES FROM 1987 TO 2016 IN MAINLAND FRANCE AU - Donzeau, Aurelie AU - Piffaretti, Clara AU - Jossens, Anne AU - Levaillant, Lucie AU - Bouhours-Nouet, Natacha AU - Amsellem-Jager, Jessica AU - Ghosn, Walid AU - Rey, Grégoire AU - Fosse-Edorh, Sandrine AU - Coutant, Régis T2 - Pediatric Diabetes AB - BACKGROUND: Mortality risk for children with type 1 diabetes (T1D) is unknown in France and their causes of death are not well documented. AIM: To determine the Standardized Mortality ratios (SMRs) and causes of death in children aged 1 to 14 years with T1D from 1987 to 2016. METHODS: The French Center for Epidemiology on Medical Causes of Death collected all death certificates in mainland France. SMRs, corrected SMRs (accounting for missing cases of deaths unrelated to diabetes), and 95% confidence intervals were calculated. RESULTS: Of 146 deaths with the contribution of diabetes, 97 were due to T1D. Mean age at death of the subjects with T1D was 8.8 ± 4.1 years (54% males). The cause of death was diabetic ketoacidosis (DKA) in 58% of the cases (70% in subjects 1-4 years), hypoglycemia or dead-in-bed syndrome in 4%, related to diabetes but not described in 24%, and unrelated to diabetes in 14%. The SMRs showed a significant decrease across the years, except for the 1-4 age group. In the last decade (2007-2016), the crude and corrected SMRs were significantly different from 1 in the 1-4 age group (5.4 (2.3; 10.7) and 6.1 (2.8; 11.5)), no longer significant in the 5-9 age group (1.7 (0.6; 4.0) and 2.1 (0.8; 4.5) and borderline significant in the 10-14 age group (1.7 (0.8; 3.2) and 2.3 (1.2; 4.0)). CONCLUSIONS: Children with T1D aged 1-4 years still had a high mortality rate. Their needs for early recognition and safe management of diabetes are not being met. This article is protected by copyright. All rights reserved. DA - 2021/12/08/ PY - 2021 DO - 10.1111/pedi.13298 DP - PubMed J2 - Pediatr Diabetes LA - eng SN - 1399-5448 KW - children KW - death KW - diabetes KW - diabetic ketoacidosis ER -